DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ekar and Grin2a

DIOPT Version :9

Sequence 1:NP_001036250.1 Gene:Ekar / 43806 FlyBaseID:FBgn0039916 Length:899 Species:Drosophila melanogaster
Sequence 2:NP_036705.3 Gene:Grin2a / 24409 RGDID:2737 Length:1464 Species:Rattus norvegicus


Alignment Length:929 Identity:208/929 - (22%)
Similarity:380/929 - (40%) Gaps:198/929 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 PPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETT------VDYYVEYVNRFDSFETVQ 78
            ||.:.|..:..:...:...||...:.           ||..      |:.....:||.|....:.
  Rat    31 PPALNIAVLLGHSHDVTERELRNLWG-----------PEQATGLPLDVNVVALLMNRTDPKSLIT 84

  Fly    79 KVCKLI---RVGVQAVFSPTD-SVLATHINSICDALDIPNIG----------------------- 116
            .||.|:   |:........|| ..:|..::.|.....||.:|                       
  Rat    85 HVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGA 149

  Fly   117 ----------RSAHDFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHG 171
                      :...|:..:|:.....:...:.|.|.::..|                 :..||.|
  Rat   150 SIQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFIKTT-----------------VDNSFVG 197

  Fly   172 EVHMRQVSRD-SYVSALNEFKGKEIHN--IIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDL 233
            ......::.| |:..|..:.:.|:||:  |::..:.:...::|.......:..|.:.::..|...
  Rat   198 WDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVS 262

  Fly   234 ETYDL--EDFKYNFVNITSFRLVDTADVGVKQILKD-IGLYSHHIFKKPYLNLHIKKSTILESEP 295
            ...:|  ::|....::::    .|..|..::..::| :|:.:      ...:..::|.:.:....
  Rat   263 GNTELIPKEFPSGLISVS----YDDWDYSLEARVRDGLGILT------TAASSMLEKFSYIPEAK 317

  Fly   296 ALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQR 360
            |..:.........|.||.|    .::|:      :|||             |.|:..   ::|.:
  Rat   318 ASCYGQAEKPETPLHTLHQ----FMVNV------TWDG-------------KDLSFT---EEGYQ 356

  Fly   361 VQFKLDLIKL-KQHSIVKVGEWTPH----GHLNITEPSMFFDAGSMNVTLVVITILETPYVMMH- 419
            |..:|.:|.| |.....|||:|...    .|........|.|....:..|.::|:.|.|:|::. 
  Rat   357 VHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVED 421

  Fly   420 -----------------YGK-NFTGNERF------YGFCVDILETISREVGFDYILDLVPDRKYG 460
                             :.| |.:.||..      .|||:|||:.:||.|.|.|.|.||.:.|:|
  Rat   422 IDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHG 486

  Fly   461 AKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVP--TSEPTRL 523
            .|  ....||||:.:::..:|.:||||:||...|..|:||:.||:..|||::....  |..|:  
  Rat   487 KK--VNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPS-- 547

  Fly   524 FSFMNPLAIEIWIYVLIAYFLVS-LCIYIVGKLSPIEWKCINACDLENISIGN-----QFSLTDS 582
             :|:.|.:..:|:.:.:...:|| :.:::....||:.:.       .|::.|.     .|::..:
  Rat   548 -AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYN-------RNLAKGKAPHGPSFTIGKA 604

  Fly   583 FWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLA 646
            .|...| .|....|...|:..:::|:.|.|.||::|.:||||||||||:..|..::.:....|..
  Rat   605 IWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKK 669

  Fly   647 SQTEISY------GTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNY- 704
            .|....|      ||:.:|||....|::.  .|...:.:..|::      ..||.:..:..|.. 
  Rat   670 FQRPHDYSPPFRFGTVPNGSTERNIRNNY--PYMHQYMTRFNQR------GVEDALVSLKTGKLD 726

  Fly   705 AFLMESTMLDYIVQRD--CNLTQIGG--LLDTKGYGIATPKGSPWRDKISLAILELQERGDIQML 765
            ||:.::.:|:|...||  |.|..||.  :..|.|||||..|||||:.:|.||:|:....|:::.|
  Rat   727 AFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEEL 791

  Fly   766 YDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFE--FWYNFRYNYEA 828
            ...|.     |....|...:..::.|.::::.|||.:|.|.:.::.:...:|  |::..|:.:..
  Rat   792 ETLWL-----TGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTG 851

  Fly   829 TPSQSVVNNKYNQDGILES 847
            ..|        ::.|:|.|
  Rat   852 VCS--------DRPGLLFS 862

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
EkarNP_001036250.1 PBP1_iGluR_Kainate 24..388 CDD:107377 67/417 (16%)
ANF_receptor 39..371 CDD:279440 60/381 (16%)
PBP2_iGluR_Kainate 402..771 CDD:270432 122/413 (30%)
Lig_chan 533..807 CDD:278489 80/291 (27%)
Grin2aNP_036705.3 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373 68/423 (16%)
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 123/423 (29%)
HisJ <458..>541 CDD:223904 37/84 (44%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY 511..513 1/1 (100%)
Lig_chan 556..828 CDD:278489 80/291 (27%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1 599..620 5/20 (25%)