DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Grik5

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_006228444.1	Gene:	Grik5 / 24407	RGDID:	2735	Length:	980	Species:	Rattus norvegicus

Alignment Length:	915	Identity:	336/915 - (36%)
Similarity:	503/915 - (54%)	Gaps:	98/915 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYVEYVNRF 71
            |:..|.:....|...:|:.||..:|......| ||...|..::|....:..:..|:..:..:.|.
  Rat     9 LIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRD 73

  Fly    72 DSFETVQKVCKLIRVGVQAVFSPTDS-VLATHINSICDALDIPNIGRSAHD---------FSINV 126
            ..:||...:|:::..||.:|..|:.| ..|:.::.||...:||:|.....:         .|:::
  Rat    74 SQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSL 138

  Fly   127 YPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHMRQVSRDSYVSA 186
            |||.:.|:.|.:.:::..|:....::..|...::.|.:|.|.|     ...|.|...|||. ...
  Rat   139 YPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDP-TPL 202

  Fly   187 LNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSF 251
            |.|.:..::..||||.|::...::|:...:..|....|.|:.|:.|.....|:....:..||..|
  Rat   203 LKEIRDDKVSTIIIDANASISHLVLRKASELGMTSAFYKYILTTMDFPILHLDGIVEDSSNILGF 267

  Fly   252 RLVDTADVGVKQILKDIGLYSHHIFKKPY---LNLHIKKSTILESEP------ALMFDSVYVFAI 307
            .:.:|:                |.|...:   ||:..:::....:.|      |||||:|:|...
  Rat   268 SMFNTS----------------HPFYPEFVRSLNMSWRENCEASTYPGPALSAALMFDAVHVVVS 316

  Fly   308 GLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLK 371
            .::.|.:|..:.:..::|...|.|..|.||:|||..||:.||||.::|.. |||..:.|.:::..
  Rat   317 AVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKS 381

  Fly   372 QHSIVKVGEWTPHGHL--NITEPSMFFDAGSMNVTLVVITILETPYVMMHYGKNF---TGNERFY 431
            :....::|.|..:..|  |.|...:.......|.||||.||||.||||..  .||   :|||||.
  Rat   382 RQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTILENPYVMRR--PNFQALSGNERFE 444

  Fly   432 GFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLM-KYKADLAVGSMTITYARE 495
            |||||:|..::..:.|.|.|.||.|..|||.:| .|.|.|||.:|: :.||||||.:.|||..||
  Rat   445 GFCVDMLRELAELLRFRYRLRLVEDGLYGAPEP-NGSWTGMVGELINRQKADLAVAAFTITAERE 508

  Fly   496 SVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW 560
            .||||:||||.||||||::|........|||::|.:..:|:::|:||..||..:::..:|||.||
  Rat   509 KVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEW 573

  Fly   561 ----KCINACD--LENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIV 619
                .|:.|..  ||     ||::|.:|.||.:|.||||..:|.|||:|||.:|..|..|:|||:
  Rat   574 YNPHPCLRARPHILE-----NQYTLGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIII 633

  Fly   620 ASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKK 684
            :|||||||||||.:||..|:|:|:|||.||.|.|||:.:|||||||::|..:||:::|..|.:|:
  Rat   634 SSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQ 698

  Fly   685 PSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKI 749
            ||.|..:.|:||.||....||||:||||.:|..:.:|||||||||||||||||..|.|||:||:|
  Rat   699 PSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEI 763

  Fly   750 SLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVA 814
            :||||:|||...:::|..|||:.  ..|.::   :..:|..||:|:|||:|||||.|:|:|..||
  Rat   764 TLAILQLQENNRLEILKRKWWEG--GRCPKE---EDHRAKGLGMENIGGIFVVLICGLIIAVFVA 823

  Fly   815 FFEFWYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPDRSFWIEIAEELRYASWC-----MN 874
            ..||.::.|.:.|   |:.|                      |...|:.:|||:|..|     ..
  Rat   824 VMEFIWSTRRSAE---SEEV----------------------SVCQEMLQELRHAVSCRKTSRSR 863

  Fly   875 KQKRP 879
            :::||
  Rat   864 RRRRP 868

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	97/391 (25%)
		ANF_receptor	39..371	CDD:279440	90/357 (25%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	200/378 (53%)
		Lig_chan	533..807	CDD:278489	142/279 (51%)
Grik5	XP_006228444.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	97/394 (25%)
Grik5	XP_006228444.1	Periplasmic_Binding_Protein_Type_2	414..785	CDD:389745	200/378 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350214
Domainoid	1	1.000	362	1.000	Domainoid score	I917
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.710