DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Grik4

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_036704.1	Gene:	Grik4 / 24406	RGDID:	2734	Length:	956	Species:	Rattus norvegicus

Alignment Length:	920	Identity:	336/920 - (36%)
Similarity:	503/920 - (54%)	Gaps:	106/920 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 PPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKL 83
            |..:||.||..:.......| |:...|.:|:|.....|.:..|:..:..:.|...:||.:.:|::
  Rat    22 PHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQI 86

  Fly    84 IRVGVQAVFSPTDSVLATH-INSICDALDIPNIGRSAHDF---------SINVYPSKQLVNYAFN 138
            :..||.||..|:.|..::. |::||...::|:...:..:|         ::|::||...::.|..
  Rat    87 LPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVRFQLQRFTTLNLHPSNTDISVAVA 151

  Fly   139 DVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHMRQVSRDSYVSALNEFKGKEIHNI 198
            .::.:.|.|...::..|...::||.:|.|.|     ...|.|...:||. ...|.|.:..:...|
  Rat   152 GILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDP-TPLLKEIRDDKTATI 215

  Fly   199 IIDTN-SNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVK 262
            ||..| |...:||||......::.| |.|:||:.:.....::....:.|||..|.:.:.:....:
  Rat   216 IIHANASMSHTILLKAAELGMVSAY-YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQ 279

  Fly   263 QILKDIGL-----YSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLN 322
            :..:.:..     ..|..|..|.|:            .||:||:||.....:|.|.:|..:.:..
  Rat   280 EFSQSLNQSWQENCDHVPFTGPALS------------SALLFDAVYAVVTAVQELNRSQEIGVKP 332

  Fly   323 ISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLKQHSIVKVGEWTPHGH 386
            :||.....|..|.||:|||..||.:||||.|:|.. |||..:.|.:::..::...::|:|    |
  Rat   333 LSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFRQIGQW----H 393

  Fly   387 L-------------NITEPSMFFDAGSMNVTLVVITILETPYVMM---HYGKNFTGNERFYGFCV 435
            :             ||:: |:|      |.||||.||||.||:|:   |  ::..||:|:.||||
  Rat   394 VAEGLSMDSRLYASNISD-SLF------NTTLVVTTILENPYLMLKGNH--QDMEGNDRYEGFCV 449

  Fly   436 DILETISREVGFDYILDLVPDRKYGAKDPE-TGEWNGMVAQLMKYKADLAVGSMTITYARESVID 499
            |:|:.::..:.|:|.:.||.|..||.  || .|.|.|||.:|:..||||||..:|||..||.|||
  Rat   450 DMLKELAEILRFNYKIRLVGDGVYGV--PEANGTWTGMVGELIARKADLAVAGLTITAEREKVID 512

  Fly   500 FTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW---- 560
            |:||||.||||||::|........|||::|.:..:|:::|:||..||..:::|.:|:|.||
  Rat   513 FSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPH 577

  Fly   561 KCINA-CDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTA 624
            .|... |:|    :.||:||.:|.||.:|.||||...|.|||:|||.:|..|..|:|||::||||
  Rat   578 PCAQGRCNL----LVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTA 638

  Fly   625 NLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFT 689
            |||||||.:||..|||:.:|||.||.|.|||:..||:||||::|..:||:::|..|.:|:||.|.
  Rat   639 NLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFV 703

  Fly   690 TTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAIL 754
            .:.|:||.||...|||||:||||.:|..||:|||||||||||||||||..|.||.:||:..||||
  Rat   704 KSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAIL 768

  Fly   755 ELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFW 819
            :|||...:::|..|||:.  ..|.::   :..:|..||:|:|||:|||||.|:|||..:|..||.
  Rat   769 QLQENNRLEILKRKWWEG--GKCPKE---EDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFL 828

  Fly   820 YNFRYN--YEATPSQSVVNNKYN----QDGILESERNY--TPPDRSFWIEIAEELRYASWCMNKQ 876
            :..|::  .|.:..|.::....:    ||.|....|..  .||..    .:.||
  Rat   829 WTLRHSEASEVSVCQEMMTELRSIILCQDNIHPRRRRSGGLPPQP----PVLEE----------- 878

  Fly   877 KRPALTRTCS 886
            :||..|.|.|
  Rat   879 RRPRGTATLS 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	99/399 (25%)
		ANF_receptor	39..371	CDD:279440	92/354 (26%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	195/377 (52%)
		Lig_chan	533..807	CDD:278489	142/278 (51%)
Grik4	NP_036704.1	Periplasmic_Binding_Protein_type1	24..402	CDD:415822	99/395 (25%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	195/377 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..956
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.610