DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Grin3a

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_612555.1	Gene:	Grin3a / 191573	RGDID:	621704	Length:	1135	Species:	Rattus norvegicus

Alignment Length:	932	Identity:	204/932 - (21%)
Similarity:	365/932 - (39%)	Gaps:	201/932 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 AFRYAIHRLNMDKSLLPETTVDYYVEYVNRF---------------------DSFETVQKVCKLI 84
            |..:|:..||..:.|||   .:..:|.|...                     |.|..:|.||..:
  Rat   127 ALLFAVENLNRVEGLLP---YNLSLEVVMAIEAGLGDLPLMPFSSPSSPWSSDPFSFLQSVCHTV 188

  Fly    85 RV-GVQAVFS-PTDSVLATHINSICDALDIPNIGRSAHDF---SIN-VYPSKQLVNYAFND---- 139
            .| ||.|:.: |........::.:...|.||.:....|:|   |.| ::....|.|...:|
  Rat   189 VVQGVSALLAFPQSQGEMMELDLVSSVLHIPVLSIVRHEFPRESQNPLHLQLSLENSLSSDADVT 253

  Fly   140 --VIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDT 202
              ::...||..|.:|..:|:..|....|....:.:.|:..|                   |.|..
  Rat   254 VSILTMNNWYNFSLLLCQEDWNITDFLLLTENNSKFHLESV-------------------INITA 299

  Fly   203 NSNGISILLKNILQQQM----NEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRL-------VDT 256
            |.:....|| :.||.||    |......:|..      |::..:..|...|.|.|       |..
  Rat   300 NLSSTKDLL-SFLQVQMDNIRNSTPTMVMFGC------DMDSIRQIFEMSTQFGLSPPELHWVLG 357

  Fly   257 ADVGVKQILKD---IGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSL 318
            ....|:::..:   :||.:|....:.....:::.:..|.:.           |:...|:.|. .|
  Rat   358 DSQNVEELRTEGLPLGLIAHGKTTQSVFEYYVQDAMELVAR-----------AVATATMIQP-EL 410

  Fly   319 TLL--NISCEEENSWD--GGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLD-LIKLKQHSIV-- 376
            .||  .::|.:..:.:  .|..|..:|....::||:|.|:.|....:..:.: .|...||..:
  Rat   411 ALLPSTMNCMDVKTTNLTSGQYLSRFLANTTFRGLSGSIKVKGSTIISSENNFFIWNLQHDPMGK 475

  Fly   377 ----KVGEWTPHGHLNITEPSMFFDAGSMNVT---------LVVITILETPYVMMH--------- 419
                ::|.|  .|...:.:..::.:....:.|         |.|:|::|.|:|...
  Rat   476 PMWTRLGSW--QGGRIVMDSGIWPEQAQRHKTHFQHPNKLHLRVVTLIEHPFVFTREVDDEGLCP 538

  Fly   420 -----------------------YGKNFTGNERF----YGFCVDILETISREVGFDYILDLVPDR 457
                                   :..|.|...:|    ||:|:|:||.::.::.||:.|.:|.|.
  Rat   539 AGQLCLDPMTNDSSMLDRLFSSLHSSNDTVPIKFKKCCYGYCIDLLEQLAEDMNFDFDLYIVGDG 603

  Fly   458 KYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKV-PTSEPT 521
            ||||.  :.|.|.|:|..|:...|::||.|.:|..||..|||||.||.:..:.||.:. .|:.|
  Rat   604 KYGAW--KNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAP- 665

  Fly   522 RLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDS---- 582
             :.:||.||...:|:.:.:|..:.::.      |:..|||.......:..:....||.:.:
  Rat   666 -IGAFMWPLHWTMWLGIFVALHITAIF------LTLYEWKSPFGMTPKGRNRNKVFSFSSALNVC 723

  Fly   583 FWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAED--L 645
            :....|......|   |:..:.|.:.:.|..|.:..:::|||||||.:..|::...:....|  |
  Rat   724 YALLFGRTAAIKP---PKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKL 785

  Fly   646 ASQTE-ISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNY---AF 706
            ...:: ..:||:...|...:.|.|..|.::.:.|......|        ||::.:.....   ||
  Rat   786 HHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATP--------DGVQYLKNDPEKLDAF 842

  Fly   707 LMESTMLDY--IVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKW 769
            :|:..:|||  .:..||.|..:|.....:||||..|..||....||..|.:.:..|.:.:|:|||
  Rat   843 IMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTSNISELISQYKSHGFMDVLHDKW 907

  Fly   770 WKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAF------------------F 816
            :|..  .|.:::.: .::...:|::...|:||:|..|..::.:...                  .
  Rat   908 YKVV--PCGKRSFA-VTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVHRLLLPRIKNKSKL 969

  Fly   817 EFWYNFRYNYEATPSQSVVNNK 838
            ::|.:....:....:.|.|..|
  Rat   970 QYWLHTSQRFHRALNTSFVEEK 991

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	81/404 (20%)
		ANF_receptor	39..371	CDD:279440	76/381 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	111/426 (26%)
		Lig_chan	533..807	CDD:278489	66/285 (23%)
Grin3a	NP_612555.1	PBP1_iGluR_NMDA_NR3	30..497	CDD:107372	81/412 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117
		ANF_receptor	127..469	CDD:279440	76/382 (20%)
		PBP2_iGluR_NMDA_Nr3	512..908	CDD:270438	109/416 (26%)
		Lig_chan	676..942	CDD:278489	66/285 (23%)
		PPP2CB binding site	951..987		1/35 (3%)
		GIT1-binding. /evidence=ECO:0000269\|PubMed:24297929	1082..1115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350033
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740