Protein Alignment Ekar and glr-6

DIOPT Version :9

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_741822.2
• Gene: glr-6 / 180955
• WormBaseID: WBGene00001617
• Length: 844
• Species: Caenorhabditis elegans
• Alignment Length: 876
• Identity: 249/876 - (28%)
• Similarity: 406/876 - (46%)
• Gaps: 127/876 - (14%)

  Fly     1 MLIASGFLLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIH----RLNMDKSLLPET-- 59
            ||....|||..||  |.||.. :|||.|.|     ::.|.:.|.|::    |:|   ..:.:|
 Worm     1 MLNIFRFLLLSFL--GTGVSS-IRIGLITS-----HHLEHSVRTAVNIIVPRIN---EQIVKTRG 54

  Fly    60 ----TVDYYVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIG---- 116
                |...::...|..:...|  |:|.|....|..:....|....:.|...|..|:|..|.
 Worm    55 ACFITHTSFIALKNSHEDLNT--KICDLANSEVSVIIGVVDRESGSIIEEQCAELNILFIHYYWT 117

  Fly   117 ---RSAHDFSINVYPSKQLVNYAFNDVIQYLNWTRFGILH----------------EKENGIINL 162
               :.....|:|:|||.: .:.....:|....|..|..::                ||...::..
 Worm   118 PGYQKKQQTSLNLYPSME-YSQLMERLINLWRWDNFVYIYSNYDAPKQLIETLSRLEKSPALLRA 181

  Fly   163 HQLSRSFHGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYL 227
            |.|..|........:.:.|.     |....|: :.::|:.:.|.........|:..|......:|
 Worm   182 HTLDDSMMATALALRDTCDR-----NRCWPKK-NRVLIELSPNETLTFFDASLKLGMISVHNWFL 240

  Fly   228 FTSFDLETYDLEDFKYNFVNIT----SFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKS 288
            .|:.|.....|..:.:|.:.::    |....:..|:.:|  |.|  :|..::.|.|
 Worm   241 ITALDDLNDHLSQYTHNGMRVSLLTVSKEKWNQNDLAIK--LPD--MYQEYLAKIP--------- 292

  Fly   289 TILESEP-------ALMFDSVYVFAIGLQTLEQSHSLTLLNISC-EEENSWDGGLSLINYLNAVE 345
                |.|       |.:|||:.:..       |:....:  ||| :.|......|.::.     .
 Worm   293 ----SNPRTPFKDFAFIFDSILLAC-------QAGDRRI--ISCGDNEAVKKFKLPIVK-----P 339

  Fly   346 WKGLTGPIQF------KDGQRVQFKLDLIKLKQHSIVKVGEWTPHGHL-----NITEPSMFFDAG 399
            :|||||.|.|      .|.:...:::.:.....|:.:....|.....|     ||......:.|.
 Worm   340 FKGLTGKISFNGTSDRSDSELHIWEMGITGAGLHTGIWKSTWEGSKELTMLAKNIPGTHEHYQAS 404

  Fly   400 -SMNVTLVVITILETPYVMMHYGKNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKD 463
             ..:.||.|.:|.|.|||:.....:  |..:..|||||:|:.::..:.|:|.|.:|.|.|||.:.
 Worm   405 VRESRTLKVTSIHEKPYVIEKIMPD--GRIKHEGFCVDLLDKLAEMLHFNYTLKIVKDNKYGERK 467

  Fly   464 PETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPT-SEPTRLFSFM 527
            ..|.||:||:.::::..||:||..:|:|..|..|||||.||:.||||:|.:.|. ...:.|..|:
 Worm   468 NGTDEWDGMIGEILRGDADMAVAPITVTATRLEVIDFTDPFLQLGISMLMRQPNPKSSSSLTRFL 532

  Fly   528 NPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQ 592
            .||:..:|.:..||..:.:|.:.:...|||.|...             :|.:.:|.|:.:...::
 Worm   533 WPLSASVWTFSAIATVITALLVTVAAVLSPKESTA-------------EFKIQNSVWYLVCILLR 584

  Fly   593 QSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLD 657
            .......:|.:||:||:.|..|:|:::|.||||.||.||.:|...|..:.|:|.:|||.::|::.
 Worm   585 AGSGYNCQAGATRLISAVWWSFTLVLIAQYTANFAALLTVDRKSMPFNSFEELGNQTEYNFGSIL 649

  Fly   658 SGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCN 722
            .||||.||:.|.|||::::|..|.:.:||||..|..:|:.||....|.|||||..|||.|.::||
 Worm   650 GGSTMQFFKYSRIETFRRLWERMQSAEPSAFVGTNHEGVNRVLNEKYVFLMESATLDYQVTQNCN 714

  Fly   723 LTQIGG-LLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQS 786
            ||::|. :|.:.||.||.||||.||:|::..||:|.|:|.|.||.:.|||.:.:.|  :::..:.
 Worm   715 LTRVGNVVLGSNGYSIALPKGSKWREKLTRQILDLNEKGIILMLKNNWWKKSQQEC--QSSEPED 777

  Fly   787 KANSLGLESIGGVFVVLIAGIIVAAVVAFFE 817
            ...:||.|::.|:|::|..|..:..:.|..|
 Worm   778 LQTALGAENVYGLFLLLALGSGIGVLCAVLE 808

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	80/419 (19%)
		ANF_receptor	39..371	CDD:279440	72/382 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	144/370 (39%)
		Lig_chan	533..807	CDD:278489	101/274 (37%)
glr-6	NP_741822.2	PBP1_iGluR_non_NMDA-like	21..394	CDD:380591	80/420 (19%)
		PBP2_iGluR_Kainate	409..764	CDD:270432	144/369 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920