Protein Alignment Ekar and glr-8

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_001368711.1
• Gene: glr-8 / 180924
• WormBaseID: WBGene00001619
• Length: 547
• Species: Caenorhabditis elegans
• Alignment Length: 483
• Identity: 122/483 - (25%)
• Similarity: 196/483 - (40%)
• Gaps: 84/483 - (17%)

  Fly   406 VVITILETPYVMMHYGKNFTG---NERFY--GFCVDILETISREVGFDYILDLVPDRKYGAKDPE 465
            :|:..:|.|||  :| .||:.   .::.|  |..::||:.|.:.:...|  :::|  ..|:...|
 Worm    66 MVVPAIEPPYV--NY-VNFSDAAVTDKGYGPGVVMEILKEIGKRLNLTY--EILP--ALGSTWGE 123

  Fly   466 --TGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTS-EPTRLFSFM 527
              .|.|.|...||::.:.||..|...:.|.|..:.|.|.||......|:.:.|.. |...|....
 Worm   124 YLNGSWTGAFGQLVRGEVDLLAGGAIMEYDRSVIADLTYPFQFEPTGIMIRSPEKYEDDTLLIVT 188

  Fly   528 NPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENI--SIGNQFSLT--DSFWFTIG 588
            .|.:.|:|: :..|..|:|..|::|               :.||  .:..:.::|  :|.|....
 Worm   189 EPFSWEVWV-ITAAVILISGVIFLV---------------MTNIIRKVYEEMTVTPFESIWVFFS 237

  Fly   589 TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLA-----SQ 648
            .|:||.....||:.|.|::.:.|...|:.:.|::|.:|.|....::...|.:|.:.|.     .:
 Worm   238 IFVQQGLPEQPRSWSCRVLVALWWLASITLSATFTGSLVALFAVDKTNVPFQNIDQLVRLVKQGK 302

  Fly   649 TEISYGTLDSGS-TMT-FFRDSVIETYKKIWRSM-DNKKPSAFTTTYEDGIK------RVNQGNY 704
            .||   .:|..| |.| ....|.:..|:.:|..| .|.|     ..|.:||.      |.|.| |
 Worm   303 FEI---VMDENSFTRTEMIARSKLPVYRDLWHEMIVNHK-----VKYVNGIARGVAFVRANPG-Y 358

  Fly   705 AFLMESTMLDYIVQRDCNLTQIG-GLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDK 768
            |.|.....|::....||.:.... |:|... ..|...|.|.:....|..|.|:.|||..|    |
 Worm   359 ALLGPMATLNFYAYSDCKVILFNDGILPVY-LSIPLVKNSIYSPYFSTKIREMVERGFTQ----K 418

  Fly   769 WWKN-----TDETCTRKNTSKQSKANSLGLESIGGVFVVLI--AGIIVAAVVAFFEFWYNFRYNY 826
            |..:     ..:.....|::.....:.|.|:...|.|.|.:  ||:.:|..|..|.|.: ||...
 Worm   419 WIADYRSYVAMQKINECNSTTIGPKSYLDLKRAQGAFWVFLGGAGLGLALFVGEFIFKF-FREKM 482

  Fly   827 E------------ATPSQSVVNNKYNQD 842
            .            ||.|.:|..|..:.|
 Worm   483 TKHTKTTTVPPEVATVSANVAENSTSLD 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605
		PBP2_iGluR_Kainate	402..771	CDD:270432	102/391 (26%)
		Lig_chan	532..806	CDD:459656	72/299 (24%)
glr-8	NP_001368711.1	PBP2_iGluR_ligand_binding	62..424	CDD:270219	102/394 (26%)