DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and glr-8

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001368711.1	Gene:	glr-8 / 180924	WormBaseID:	WBGene00001619	Length:	547	Species:	Caenorhabditis elegans

Alignment Length:	483	Identity:	122/483 - (25%)
Similarity:	196/483 - (40%)	Gaps:	84/483 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 VVITILETPYVMMHYGKNFTG---NERFY--GFCVDILETISREVGFDYILDLVPDRKYGAKDPE 465
            :|:..:|.|||  :| .||:.   .::.|  |..::||:.|.:.:...|  :::|  ..|:...|
Worm    66 MVVPAIEPPYV--NY-VNFSDAAVTDKGYGPGVVMEILKEIGKRLNLTY--EILP--ALGSTWGE 123

  Fly   466 --TGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTS-EPTRLFSFM 527
              .|.|.|...||::.:.||..|...:.|.|..:.|.|.||......|:.:.|.. |...|....
Worm   124 YLNGSWTGAFGQLVRGEVDLLAGGAIMEYDRSVIADLTYPFQFEPTGIMIRSPEKYEDDTLLIVT 188

  Fly   528 NPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENI--SIGNQFSLT--DSFWFTIG 588
            .|.:.|:|: :..|..|:|..|::|               :.||  .:..:.::|  :|.|....
Worm   189 EPFSWEVWV-ITAAVILISGVIFLV---------------MTNIIRKVYEEMTVTPFESIWVFFS 237

  Fly   589 TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLA-----SQ 648
            .|:||.....||:.|.|::.:.|...|:.:.|::|.:|.|....::...|.:|.:.|.     .:
Worm   238 IFVQQGLPEQPRSWSCRVLVALWWLASITLSATFTGSLVALFAVDKTNVPFQNIDQLVRLVKQGK 302

  Fly   649 TEISYGTLDSGS-TMT-FFRDSVIETYKKIWRSM-DNKKPSAFTTTYEDGIK------RVNQGNY 704
            .||   .:|..| |.| ....|.:..|:.:|..| .|.|     ..|.:||.      |.|.| |
Worm   303 FEI---VMDENSFTRTEMIARSKLPVYRDLWHEMIVNHK-----VKYVNGIARGVAFVRANPG-Y 358

  Fly   705 AFLMESTMLDYIVQRDCNLTQIG-GLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDK 768
            |.|.....|::....||.:.... |:|... ..|...|.|.:....|..|.|:.|||..|    |
Worm   359 ALLGPMATLNFYAYSDCKVILFNDGILPVY-LSIPLVKNSIYSPYFSTKIREMVERGFTQ----K 418

  Fly   769 WWKN-----TDETCTRKNTSKQSKANSLGLESIGGVFVVLI--AGIIVAAVVAFFEFWYNFRYNY 826
            |..:     ..:.....|::.....:.|.|:...|.|.|.:  ||:.:|..|..|.|.: ||...
Worm   419 WIADYRSYVAMQKINECNSTTIGPKSYLDLKRAQGAFWVFLGGAGLGLALFVGEFIFKF-FREKM 482

  Fly   827 E------------ATPSQSVVNNKYNQD 842
            .            ||.|.:|..|..:.|
Worm   483 TKHTKTTTVPPEVATVSANVAENSTSLD 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377
		ANF_receptor	39..371	CDD:279440
		PBP2_iGluR_Kainate	402..771	CDD:270432	102/391 (26%)
		Lig_chan	533..807	CDD:278489	73/299 (24%)
glr-8	NP_001368711.1	PBP2_iGluR_ligand_binding	62..424	CDD:270219	102/394 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810