DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and glr-4

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001254126.1	Gene:	glr-4 / 174258	WormBaseID:	WBGene00001615	Length:	951	Species:	Caenorhabditis elegans

Alignment Length:	885	Identity:	303/885 - (34%)
Similarity:	468/885 - (52%)	Gaps:	127/885 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IASGF--LLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYV 65
            :..||  ||..|............||.|.:.....|..   .||||.|.|.:..  ..|.:.:.:
Worm     7 LVRGFSILLVIFYIANSAADDRFHIGTIANRGSFAYEH---LRYAIDRWNTEHG--AHTQIKFSI 66

  Fly    66 EYVNRFD-SFETVQKVCKLIRVGVQAVF-----SPTDSVLATHINSICDALDIP-------NIGR 117
            ....|:| ::|  :::|::::.|:.||.     |..||.|   |.|:|...:||       ::..
Worm    67 VSPIRYDNNYE--ERMCEIMQQGIVAVVLSNEESEQDSQL---IKSMCHYFNIPCLSLQSTSLRD 126

  Fly   118 SAHDFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQL----------SRSFHGE 172
            |..||...:.||:.....|.::.:..:.||.|.:.::..:.:.:|..|          .|..|.:
Worm   127 SVSDFVTLLGPSRGAGARATSEFLDSMRWTGFLLAYQHGSDLEDLSPLMQYKQIVDTGGRRIHIK 191

  Fly   173 VHMRQVSRDSYVSALNEFKGK-EIHNIIIDTNSNGISILLKNILQQ----QMNEYKYHYLFTSFD 232
            :.....:.|.|...|...|.: :..||||  :||.|::|. |:|||    .|.|..:.|:||:.|
Worm   192 IRRLPNNTDDYEPFLKYVKTRLKQTNIII--HSNNITVLY-NLLQQARGLNMAEPPFSYVFTNTD 253

  Fly   233 LETYDLEDFKYNF------VNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTIL 291
            |..  ||||..|.      .|||..:||                               |...::
Worm   254 LSL--LEDFLNNMYGASFHCNITGLQLV-------------------------------KNDPMM 285

  Fly   292 ESEPALMFDSVYVFAIGLQTL-EQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKG-LTGPIQ 354
            :::.||..::|||..:.:..: |..|:....:|.|:..:.|..|..:...:..::.:. |||.:|
Worm   286 KTQLALTSEAVYVVGMSIYRMRELGHAPRQSSIMCDSHDIWSDGRIMNEGIRKLKLRNQLTGDVQ 350

  Fly   355 FK-DGQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMFFDAGSMN---------------V 403
            || :|:|.......:.......||:|.|:.....|       ||:...|               :
Worm   351 FKSNGERDDIMYHGVGRINSQFVKLGNWSEKRGWN-------FDSRYANRWEFDIDPDSEDLEGL 408

  Fly   404 TLVVITILETPYVMMHYGKNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGE 468
            .|.|:..||.|:|:.      ||..::.|||:|:|..:::.:.|:|.:..|.|..||.:| |:|.
Worm   409 HLRVVVYLEEPFVIK------TGENQYEGFCIDLLNEMTQVLKFNYTIIEVQDGTYGIED-ESGR 466

  Fly   469 WNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPT---RLFSFMNPL 530
            |||::..|.:::|||::.::||||:|..|:|||.|||:||||||. ..|||.|   .|::|:.||
Worm   467 WNGIIGALQRHEADLSLSAVTITYSRAEVVDFTLPFMHLGISILL-ARTSEETDKGSLWTFLEPL 530

  Fly   531 AIEIWIYVLIAYFLVSLCIYIVGKLSPIEW---KCINACDLENI-SIGNQFSLTDSFWFTIGTFM 591
            ::.:||.:||:|.:||..::|:.|.||.||   :.|:..|.||| :..|||::.:|||||:|:.|
Worm   531 SLTVWISLLISYCIVSYSMHILAKFSPYEWYNLERIDERDFENIKNQKNQFTVLNSFWFTMGSLM 595

  Fly   592 QQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTL 656
            ||..|:.|||.:||:|:..|..|:.||::||||.||||||.|||..|||:.:|||:|.:|.||.|
Worm   596 QQGSDVIPRAAATRLIAVVWWMFTQIIISSYTAQLAAFLTVERMSTPIESTQDLANQQKIRYGVL 660

  Fly   657 DSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDC 721
            .|||||.|||:|.|..|:::|..|::..|..|..:..:||.||..|.||::|||:||:|.::|||
Worm   661 KSGSTMDFFRESKIPMYERMWSVMESSSPGVFVNSSREGIARVKSGGYAYMMESSMLEYYLERDC 725

  Fly   722 NLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDE--TCTRKNTSK 784
            .|..||||||:||||||.|||||.||.:|..:|:||||..::.|.:|||::..|  :|   ....
Worm   726 ELQSIGGLLDSKGYGIALPKGSPLRDILSRTVLQLQERTILEALKNKWWRDRREGPSC---GPPP 787

  Fly   785 QSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRY 824
            ..||.:...::|.|:|.||:.|:|||.::|..|:....|:
Worm   788 SEKATNSKPQNIFGIFYVLLTGLIVAFLLACGEYCIESRH 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	97/400 (24%)
		ANF_receptor	39..371	CDD:279440	89/368 (24%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	181/390 (46%)
		Lig_chan	533..807	CDD:278489	135/279 (48%)
glr-4	NP_001254126.1	PBP1_iGluR_Kainate	30..385	CDD:107377	97/400 (24%)
		ANF_receptor	45..365	CDD:279440	89/362 (25%)
		Periplasmic_Binding_Protein_Type_2	410..775	CDD:304360	180/372 (48%)
		Lig_chan	533..810	CDD:278489	135/279 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I858
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820