DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and glr-3

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_492017.3	Gene:	glr-3 / 172449	WormBaseID:	WBGene00001614	Length:	836	Species:	Caenorhabditis elegans

Alignment Length:	854	Identity:	287/854 - (33%)
Similarity:	442/854 - (51%)	Gaps:	112/854 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 HRLNMDKSLLPETT-----VDYYVEYVN---------RFDSFETVQ--------KVCKLIRVGVQ 89
            :::.:..:|:.|..     ||:.|:.:.         :.:||:.|.        .||..:.:|..
Worm    20 YKIAIPANLIDEVNPVLEFVDFRVQVIPYETKPLWRIKQESFKIVGISIENGLFSVCNCLILGAS 84

  Fly    90 AVFSPT--DSVLATH--INSICDALDIPNIGRSAH-----DFSINVYP---SKQLVNYAFNDVIQ 142
            |:..|.  |..||..  :.||.|..::|.:  |.|     ..|.:::|   :|.|...||   |:
Worm    85 AIILPEQYDGHLAAAAIVQSIADNTNVPCV--SLHLSPPTRPSTHLHPHLNAKSLAVAAF---IK 144

  Fly   143 YLNWTRFGILHEKENGIINL---------------HQLSRSFHGEVHMRQVSRDSYVSALNEFKG 192
            ...|....::.|:.:.::.:               .||.|..||         |.|.:.|...|.
Worm   145 REKWKDVVVVFEEPDELLEITDMITAGHFDPDSFSSQLVRLKHG---------DDYGNELKHIKN 200

  Fly   193 K-EIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFK-YNFVNITSFRLVD 255
            | :.:.|:|:.........|:......|....|||:....||.|.|::..: ....|||||.:.|
Worm   201 KLDRYRIVINIPLQKALHFLEQAANMSMCGVLYHYVVMDMDLVTVDIDSIRGIEDCNITSFGVHD 265

  Fly   256 TADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLE-QSHSLT 319
            .....::.|.::|                :.||:|...:..:    .|..:|.:.||. ...|:.
Worm   266 VNSEYIEDIRQEI----------------VHKSSIRLPKKGV----PYTTSIWIDTLRLLIRSMK 310

  Fly   320 LLNISCEEE--NSWDGGLSLINYLNAVEWKGLTGPIQF-KDGQRVQFKLDLIKLKQHSIVKVGEW 381
            .:.|..|..  :||..|..:..........|::|.:.: ..|:|..:.|.:.: :..|..|..||
Worm   311 SIQIWDEPRCGSSWKSGSDIKKRFFENPLAGISGDLHWAPSGERSNYTLHVYR-RTLSFQKFAEW 374

  Fly   382 TPHGHLNITEPSMFFDAGSMNVT-----LVVITILETPYVMMHYGKNFTGNERFYGFCVDILETI 441
            :.......:..::.....|..:|     |.:...||.|:||:      |.|..:.|:|:|:|..|
Worm   375 SSRTRRIASSEAVVIANSSEKLTLEGKHLKISVYLEAPFVMI------TSNGSYEGYCIDLLHKI 433

  Fly   442 SREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMN 506
            :..:.|.|.:..|.|..||:|: ..|:|:|||.:|.:..|||||.|:||:|.|..|||||.|:|:
Worm   434 ANILKFTYTIQKVRDNAYGSKE-SNGKWSGMVGELQRGDADLAVASLTISYGRSEVIDFTVPYMH 497

  Fly   507 LGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENI 571
            ||||||||.|....:..|.||:||:.::||....:||:||:.|:|:.|:||.|....:..:.:..
Worm   498 LGISILFKKPRIRDSDWFKFMDPLSTQVWIMTFASYFVVSVAIWIIAKISPYEQFERDEDNGQYK 562

  Fly   572 SIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMI 636
            .:.|||||.:|||||:.:.|||..::.|||.|||:::..|.||:||:::||||||||.|||.||.
Worm   563 PVDNQFSLRNSFWFTVCSLMQQGSELCPRAASTRLLTGIWWFFALILISSYTANLAAVLTTRRME 627

  Fly   637 NPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQ 701
            .|||||:|||:||:|.||||..||||:||.:|.||||:::|:.| :..|..|..:.::||.||..
Worm   628 TPIENADDLAAQTKIKYGTLGRGSTMSFFNESKIETYERMWQLM-SSSPGLFVQSSKEGIARVKS 691

  Fly   702 GNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLY 766
            .:||:||||:||:|.|:|||.|.|||||:|.|||||..|||||:|:.||.|||.|||:.::..|.
Worm   692 SDYAYLMESSMLEYAVERDCELMQIGGLIDQKGYGIGLPKGSPYRELISTAILRLQEKTELTELK 756

  Fly   767 DKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPS 831
            :||||:....|.:.....|...     |||||:|::|:.|:::.||:..||    .....:.:|:
Worm   757 EKWWKDKSVVCEQPKRKDQDDG-----ESIGGIFIILVVGLVLTAVLVIFE----LITTRKPSPA 812

  Fly   832 QSVVNNKYN 840
            ||.|....|
Worm   813 QSQVIRHVN 821

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	82/395 (21%)
		ANF_receptor	39..371	CDD:279440	78/378 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	183/373 (49%)
		Lig_chan	533..807	CDD:278489	136/273 (50%)
glr-3	NP_492017.3	PBP1_iGluR_non_NMDA-like	21..385	CDD:380591	82/398 (21%)
glr-3	NP_492017.3	Periplasmic_Binding_Protein_Type_2	401..761	CDD:419667	182/367 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167322
Domainoid	1	1.000	284	1.000	Domainoid score	I858
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	1	1.000	-	-		otm14234
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.650