DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and gria3a

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_005165152.1	Gene:	gria3a / 170452	ZFINID:	ZDB-GENE-020125-5	Length:	903	Species:	Danio rerio

Alignment Length:	844	Identity:	299/844 - (35%)
Similarity:	450/844 - (53%)	Gaps:	69/844 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPET-TVDYYVEYVNRFDSFETVQKVC 81
            |.|..:.||.:|.......:|  |||:|:...|.::::..:. .::|.|:.:...:||......|
Zfish    22 GFPNQINIGGLFMRSTVQEHS--AFRFAVQLYNTNQNITEKPFHLNYNVDNLESSNSFSVTHAFC 84

  Fly    82 KLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRSAH-----DFSINVYPSKQLVNYAFNDVI 141
            .....||.|:|...|......:.|.|.||....|..|..     .|.:.:.||   :..|...::
Zfish    85 SQFSRGVYAIFGFYDRRSMNTLTSFCGALHTSFITPSFPTDTDVQFVLQMRPS---LRGALLSLL 146

  Fly   142 QYLNWTRFGILHEKENGIINLHQLSRSF---HGEVHMRQVSRD----SYVSALNEFKGKEIHNII 199
            .:..|.:|..|::.:.|...|..:..|.   :.:|..|.|...    .|...:.|...::....:
Zfish   147 AHYKWEKFVYLYDTDRGFSILQAIMESAVMNNWQVTARSVGNIVDPLEYRRIIEEMDRRQEKRFL 211

  Fly   200 IDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQI 264
            ||.....|:.:|:.::....|...|||:..:.......|:.......|||.|::::.....|:|.
Zfish   212 IDCEVERINSILEQVVIAGKNSRGYHYILANLGFTNMSLDKVFSGGANITGFQIINPDSPIVQQF 276

  Fly   265 LKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLNIS----- 324
            |:.........|.:       .:|:.|:...||..|::.|.|...:.|.:..    ::||
Zfish   277 LQRWERLDEREFPE-------SRSSPLKYTSALTHDAILVIAEAFRYLRRQR----VDISRRGSA 330

  Fly   325 --CEEENS--WDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLKQHSIVKVGEWTP- 383
              |....:  |..|:.:...|..|:.:|:||.|||.. |:|..:.:|:.::|.....|:|.|..
Zfish   331 GDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDSFGRRSNYTVDVYEMKPGGARKIGYWNEF 395

  Fly   384 HGHLNITEPSMFFDAGSM-NVTLVVITILETPYVMMHYGKNF---TGNERFYGFCVDILETISRE 444
            ...:.|.|..:..::.|: |.|:||.||:|.||||  |.:|:   .||:|:.|:|||:...|::.
Zfish   396 EKFVYIVEQQVTNESSSVENRTIVVTTIMEAPYVM--YKRNYMQLEGNDRYEGYCVDLASEIAKH 458

  Fly   445 VGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGI 509
            ||..|.|.:|.|.||||:||||..|||||.:|:..:||:||..:|||..||.||||:||||:|||
Zfish   459 VGIKYKLSIVADGKYGARDPETKTWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGI 523

  Fly   510 SILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISI- 573
            ||:.|.|......:|||::|||.|||:.::.||..||:.:::|.:.||.||...:..:.::...
Zfish   524 SIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLDDNEETKDPQTP 588

  Fly   574 ---GNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERM 635
               .|.|.:.:|.||::|.||||..||.||::|.||:...|.||:|||::|||||||||||.|||
Zfish   589 PDPPNDFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERM 653

  Fly   636 INPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRV- 699
            ::|||:|||||.||||:|||||||||..|||.|.|..|:|:|..|.:.:||.|..|..||:.||
Zfish   654 VSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFVKTTPDGVARVR 718

  Fly   700 -NQGNYAFLMESTMLDYIVQR-DCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDI 762
             ::|.:|||:||||.:||.|| .|:..::||.||:||||:||||||..|..::||:|:|.|:|.:
Zfish   719 KSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALRTPVNLAVLKLSEQGIL 783

  Fly   763 QMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIV-------AAVVAFFEFW 819
            ..|.:|||.:..|..|:.:.||.|....|         .||...|.:       ..|..|..||
Zfish   784 DKLKNKWWYDKGECGTKDSGSKVSLLTHL---------TVLPTNISIYHKHHNEFPVAGFTFFW 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	85/387 (22%)
		ANF_receptor	39..371	CDD:279440	77/354 (22%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	195/378 (52%)
		Lig_chan	533..807	CDD:278489	133/280 (48%)
gria3a	XP_005165152.1	PBP1_iGluR_AMPA_GluR3	28..399	CDD:107382	85/386 (22%)
		ANF_receptor	39..382	CDD:279440	78/358 (22%)
		PBP2_iGluR_AMPA	415..797	CDD:270433	196/383 (51%)
		Lig_chan	547..810	CDD:278489	130/262 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591878
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.640