DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and gria2b

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_005157361.1	Gene:	gria2b / 170451	ZFINID:	ZDB-GENE-020125-4	Length:	897	Species:	Danio rerio

Alignment Length:	857	Identity:	308/857 - (35%)
Similarity:	465/857 - (54%)	Gaps:	72/857 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFD 72
            |:...|....|..|.|:||.:|   |...:.|    |:..|:.|.:....|..:..:::.:...:
Zfish    11 LIALLLGMTTGGSPSVQIGGLF---PRGADQE----YSAFRIGMVQFGTAEFRLTPHIDNLEVAN 68

  Fly    73 SFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRS-----AHDFSINVYPSKQL 132
            ||......|.....||.|:|...|......|.|.|..|.:..|..|     ...|.|.:.|.
Zfish    69 SFAVTNCFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPLDGNQQFIIQMRPD--- 130

  Fly   133 VNYAFNDVIQYLNWTRFGILHEKENGIINLH-----------QLSRSFHGEVHMRQVSRD-SYVS 185
            :......:|:|..|.:|..|::.:.|:..|.           |::....|  :|:...:| :|.|
Zfish   131 IKGPLLSLIEYYKWDKFAYLYDSDRGLTTLQVVLDTAAEKKWQVTAINVG--NMKDERKDEAYRS 193

  Fly   186 ALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITS 250
            ...:.:.|:...:|:|...:.:..:::.::....:...|||:..:......||...:|...|::.
Zfish   194 LFQDLENKKERRVILDCEQDKVKDIMEQVITIGRHVKGYHYIIANLGFVDGDLSKIQYGGANVSG 258

  Fly   251 FRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESE----PALMFDSVYVFAIGLQT 311
            |::||..|..|.:            |.:.:..|..|:....:|:    .||.:|:|.|.....:.
Zfish   259 FQIVDFDDPLVSK------------FDQRWEALEEKEYPGADSKIRYTSALTYDAVQVMTEAFRY 311

  Fly   312 LEQSHSLTLLNISCEEENS---------WDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLD 366
            |.:..    ::||....|.         |..|:.:...|..|...||||.|||.. |:||.:.::
Zfish   312 LHKQR----IDISRRANNGDCLANPAVPWAQGVEIERALKQVRVDGLTGNIQFDQYGKRVNYTVN 372

  Fly   367 LIKLKQHSIVKVGEWTPHGHLNITEPSMFFD--AGSMNVTLVVITILETPYVMMHYGKN---FTG 426
            :::||.:..||:|.|.....:.:|:..:|.:  .|..|.|::|.||||.||||:.  ||   |..
Zfish   373 VMELKSNGAVKIGYWNEVDKMVVTKSDLFPNDTMGLENKTVIVTTILEAPYVMLK--KNADLFMD 435

  Fly   427 NERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTIT 491
            |||:.|:|||:...|::..||.|.|.:|.|.||||:|.||..|||||.:|:..|||:||..:|||
Zfish   436 NERYEGYCVDLAAEIAKHCGFKYQLKIVGDGKYGARDAETKIWNGMVGELVYGKADIAVAPLTIT 500

  Fly   492 YARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLS 556
            ..||.||||:||||:|||||:.|.|......:|||::|||.|||:.::.||..||:.:::|.:.|
Zfish   501 LVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFS 565

  Fly   557 PIEWKCINACD--LENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIV 619
            |.||......|  ::.....|:|.:.:|.||::|.||:|..||.||::|.||:...|.||:|||:
Zfish   566 PYEWHTEEYEDGQIQTNESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIII 630

  Fly   620 ASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKK 684
            :|||||||||||.|||::|||:|||||.||||:|||||||||..|||.|.|..:.|:|..|...:
Zfish   631 SSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIALFDKMWTYMKGAE 695

  Fly   685 PSAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCNLTQIGGLLDTKGYGIATPKGSPWR 746
            ||.|..|..:|:.||  ::|.||:|:||||.:||.|| .|:..::||.||:|||||||||||..|
Zfish   696 PSVFVKTTAEGVMRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLR 760

  Fly   747 DKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAA 811
            :.::||:|:|.|:|.:..|.:|||.:..| |.......:.|.::|.|.::.|||.:|:.|:.:|.
Zfish   761 NAVNLAVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAM 824

  Fly   812 VVAFFEFWYNFR 823
            :||..||.|..|
Zfish   825 LVALVEFCYKSR 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	87/394 (22%)
		ANF_receptor	39..371	CDD:279440	77/362 (21%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	195/376 (52%)
		Lig_chan	533..807	CDD:278489	133/278 (48%)
gria2b	XP_005157361.1	PBP1_iGluR_AMPA_GluR2	27..395	CDD:107384	87/395 (22%)
		ANF_receptor	55..377	CDD:279440	72/342 (21%)
		PBP2_iGluR_AMPA	410..790	CDD:270433	197/382 (52%)
		Lig_chan	542..820	CDD:278489	133/278 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591868
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.640