DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and gria2a

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_005170953.1	Gene:	gria2a / 170450	ZFINID:	ZDB-GENE-020125-3	Length:	893	Species:	Danio rerio

Alignment Length:	873	Identity:	311/873 - (35%)
Similarity:	470/873 - (53%)	Gaps:	92/873 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LIASGFLLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVE 66
            :|.||.||.......||..|.|:||.:|   |...:.|    |:..|:.|.:....|..:..:::
Zfish     1 MILSGLLLPALWGLALGGSPSVQIGGLF---PRGADQE----YSAFRIGMVQFGTAEFRLTPHID 58

  Fly    67 YVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRS-----AHDFSINV 126
            .:...:||......|.....||.|:|...|......|.|.|:.|.:..|..|     .:.|.:.:
Zfish    59 NLEVANSFAITNCFCSQFSRGVYAIFGFYDKKSVNTITSFCETLHVSFITPSFPADGLNQFVLQM 123

  Fly   127 YPSKQLVNYAFNDVIQYLNWTRFGILHEKENGI-------------------INLHQLSRSFHGE 172
            .|.   :......:::|..|.:|..|::.:.|:                   ||:..|...:..|
Zfish   124 RPD---IKGPLISLVEYYKWEKFAYLYDSDRGLSTLQAVLDTAAERKWQVTAINVGNLKDEWKDE 185

  Fly   173 VHMRQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYD 237
                     :|.|...:.:.|....:|:|...:.:..:::.::....:...|||:..:|.....|
Zfish   186 ---------AYRSLFQDLENKNERRVILDCEQDKVKDIMEQVITIGRHVKGYHYIIANFGFVDGD 241

  Fly   238 LEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESE----PALM 298
            |...:|...|::.|::||..|..|.:            |.:.:..|..|:....:|.    .||.
Zfish   242 LSKIQYGGANVSGFQIVDFDDPLVAK------------FDQRWEALEEKEYPGADSRIRYTSALT 294

  Fly   299 FDSVYVFAIGLQTLEQSHSLTLLNISCEEENS---------WDGGLSLINYLNAVEWKGLTGPIQ 354
            :|:|.|.....:.|.:..    ::||....|.         |..|:.:...|..|...||||.||
Zfish   295 YDAVQVMTEAFRFLHKQR----IDISRRGNNGDCLANPAVPWAQGVEIERALKQVRVDGLTGNIQ 355

  Fly   355 FKD-GQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMFFD--AGSMNVTLVVITILETPYV 416
            |.. |:||.:.:::::||....||:|.|.....:.:|:..:|.:  .|..|.|::|.||||.|||
Zfish   356 FDQYGRRVNYTVNVMELKNSGPVKIGYWNEMDKMAVTKSDLFPNDTMGMENKTVIVTTILEAPYV 420

  Fly   417 MMHYGKN---FTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMK 478
            |:.  ||   ||.|||:.|:|||:...|::..||.|.|.:|.|.||||:|.||..|||||.:|:.
Zfish   421 MLK--KNAELFTDNERYEGYCVDLAAEIAKHCGFKYQLRIVADGKYGARDAETKIWNGMVGELVY 483

  Fly   479 YKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYF 543
            .|||:||..:|||..||.||||:||||:|||||:.|.|......:|||::|||.|||:.::.||.
Zfish   484 GKADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYI 548

  Fly   544 LVSLCIYIVGKLSPIEWKCINACDLENISIG-----NQFSLTDSFWFTIGTFMQQSPDIYPRAMS 603
            .||:.:::|.:.||.||   :..:.|:..:|     |:|.:.:|.||::|.||||..||.||::|
Zfish   549 GVSVVLFLVSRFSPYEW---HTEEFEDGQLGPSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLS 610

  Fly   604 TRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDS 668
            .||:...|.||:|||::|||||||||||.|||::|||:|||||.||||:|||||:|||..|||.|
Zfish   611 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFRRS 675

  Fly   669 VIETYKKIWRSMDNKKPSAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCNLTQIGGLL 730
            .|..:.|:|:.|.:.:||.|.....:|:.||  ::|.||:|:||||.:||.|| .|:..::||.|
Zfish   676 KIALFDKMWQYMKSAEPSVFVKNTVEGVLRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNL 740

  Fly   731 DTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLES 795
            |:|||||||||||..|:.::||:|:|.|:|.:..|.:|||.:..| |.......:.|.::|.|.:
Zfish   741 DSKGYGIATPKGSALRNAVNLAVLKLNEQGLLDKLKNKWWYDKGE-CGSGGGESKEKTSALSLSN 804

  Fly   796 IGGVFVVLIAGIIVAAVVAFFEFWYNFR 823
            :.|||.:|:.|:.:|.:||..||.|..|
Zfish   805 VAGVFYILVGGLGLAMLVALVEFCYKSR 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	85/401 (21%)
		ANF_receptor	39..371	CDD:279440	75/369 (20%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	196/379 (52%)
		Lig_chan	533..807	CDD:278489	133/281 (47%)
gria2a	XP_005170953.1	Periplasmic_Binding_Protein_Type_1	23..391	CDD:299141	85/402 (21%)
		ANF_receptor	51..373	CDD:279440	70/349 (20%)
		PBP2_iGluR_AMPA	406..783	CDD:270433	197/381 (52%)
		Lig_chan	538..816	CDD:278489	133/281 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591867
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.640