Protein Alignment Ekar and Grin2c

DIOPT Version :9

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_017169765.1
• Gene: Grin2c / 14813
• MGIID: 95822
• Length: 1307
• Species: Mus musculus
• Alignment Length: 820
• Identity: 204/820 - (24%)
• Similarity: 345/820 - (42%)
• Gaps: 209/820 - (25%)

  Fly   170 HGEVHMRQVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLK-------------------NIL 215
            ||.|....|..:: |:.|.:|...:.|..|:.. |.|.:::|.                   .:|
Mouse   153 HGIVFEDNVDTEA-VAQLLDFVSSQTHVPILSI-SGGSAVVLTPKEPGSAFLQLGVSLEQQLQVL 215

  Fly   216 QQQMNEYKY------------HYLFTSFDLE-TYDLEDFKYNFVNITSFRLVD--TADVG----- 260
            .:.:.||.:            |.||    || ...:.|..|     .|:||:|  |.::|
Mouse   216 FKVLEEYDWSAFAVITSLHPGHALF----LEGVRAVADASY-----LSWRLLDVLTLELGPGGPR 271

  Fly   261 --VKQILKDI------------------------GLYS-HHIFKKPYLNLHIKKSTILESEPAL- 297
              .:::|:.:                        ||.. .|::..|.|.|   .||  ::.||.
Mouse   272 ARTQRLLRQVDAPVLVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLAL---GST--DAPPAAF 331

  Fly   298 -------------------MFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLS-----LI 338
                               :.|.|.:.|:|..:..:.:.  .|.....:..|..|.:|     ..
Mouse   332 PVGLISVVTESWRLSLRQKVRDGVAILALGAHSYRRQYG--TLPAPAGDCRSHPGPVSPAREAFY 394

  Fly   339 NYLNAVEWKGLTGPIQFKD------GQRVQFKLDLIKLKQHSIVK-VGEWTPHGHLNITEPSMFF 396
            .:|..|.|:|       :|      |..||..:.:|.|.:|.:.: ||.| .||.|.:..|....
Mouse   395 RHLLNVTWEG-------RDFSFSPGGYLVQPTMVVIALNRHRLWEMVGRW-DHGVLYMKYPVWPR 451

  Fly   397 DAGSMNVT-----LVVITILETPYVMMHYGKNFTG-------------NERF------------- 430
            .:.|:...     |.|.|:.|.|:|::......||             |..|
Mouse   452 YSTSLQPVVDSRHLTVATLEERPFVIVESPDPGTGGCVPNTVPCRRQSNHTFSSGDITPYTKLCC 516

  Fly   431 YGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARE 495
            .|||:|||:.:::.|.|.|.|.||.:.|:|.:  ..|.||||:.::...:||:|:||:||...|.
Mouse   517 KGFCIDILKKLAKVVKFSYDLYLVTNGKHGKR--VRGVWNGMIGEVYYKRADMAIGSLTINEERS 579

  Fly   496 SVIDFTKPFMNLGISILF--KVPTSEPTRLFSFMNPLAIEIWIYVLI-AYFLVSLCIYIVGKLSP 557
            .:|||:.||:..|||::.  ...|..|:   :|:.|.:..:|:.:.: ...:|::.:::....||
Mouse   580 EIIDFSVPFVETGISVMVARSNGTVSPS---AFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSP 641

  Fly   558 IEWKCINACDLENISIGNQ-----FSLTDSFWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSL 616
            :.:.       :|::.|.:     |::..|.|.... .|....|...||..:::|:...|.||::
Mouse   642 VSYN-------QNLTKGKKSGGPSFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAV 699

  Fly   617 IIVASYTANLAAFLTTERMINPIENAEDLASQ------TEISYGTLDSGST----MTFFRDSVIE 671
            |.:||||||||||:..|:.|:.:....|...|      ....:||:.:|||    .:.:||....
Mouse   700 IFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTH 764

  Fly   672 TYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRD--CNLTQIGG--LLDT 732
            ..|...||:::.     .|:.:.|.:.|::...||:.::.:|:|:..:|  |.|..||.  :..|
Mouse   765 MVKFNQRSVEDA-----LTSLKMGARHVSRKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFAT 824

  Fly   733 KGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETC-TRKNTSKQSKANSLGLESI 796
            .|||||..|.|.|:..|.||:|:....|:.|.|...|...   .| ..||....||   |.::::
Mouse   825 TGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSG---ICHNEKNEVMSSK---LDIDNM 883

  Fly   797 GGVFVVLIAGIIVAAVVAFFE---FWYNFRYNYEATPSQS 833
            .|||.:|:..:.:|.:|..:|   :| ..|:   :.||.|
Mouse   884 AGVFYMLLVAMGLALLVFAWEHLVYW-KLRH---SVPSSS 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	63/315 (20%)
		ANF_receptor	39..371	CDD:279440	56/297 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	120/422 (28%)
		Lig_chan	533..807	CDD:278489	81/295 (27%)
Grin2c	XP_017169765.1	PBP1_iGluR_NMDA_NR2	90..446	CDD:380601	64/318 (20%)
		PBP2_iGluR_NMDA_Nr2	462..868	CDD:270436	121/425 (28%)
		NMDAR2_C	905..>980	CDD:371139	5/19 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846683
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740