DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Grik5

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_030098003.1	Gene:	Grik5 / 14809	MGIID:	95818	Length:	1003	Species:	Mus musculus

Alignment Length:	939	Identity:	338/939 - (35%)
Similarity:	505/939 - (53%)	Gaps:	123/939 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYVEYVNRF 71
            |:..|.:....|...:|:.||..:|......| ||...|..::|....:..:..|:..:..:.|.
Mouse     9 LIVAFANPSCQVLSSLRMAAILDDQTVCGRGERLALALAREQINGIIEVPAKARVEVDIFELQRD 73

  Fly    72 DSFETVQKVCKLIRVGVQAVFSPTDS-VLATHINSICDALDIPNIGRSAHD---------FSINV 126
            ..:||...:|:::..||.:|..|:.| ..|:.::.||...:||:|.....:         .|:::
Mouse    74 SQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPEETPRLQYLRFASVSL 138

  Fly   127 YPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHMRQVSRDSYVSA 186
            |||.:.|:.|.:.:::..|:....::..|...::.|.:|.|.|     ...|.|...|||. ...
Mouse   139 YPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLISKETLSVRMLDDSRDP-TPL 202

  Fly   187 LNEFKGKEIHNIIIDTNSN------------------------GISILLKNILQQQMNEYKYHYL 227
            |.|.:..::..||||.|::                        |:|.:|: ..:..|....|.|:
Mouse   203 LKEIRDDKVSTIIIDANASISHLVLRLSLNLSSPLGFPRSLPLGLSCVLQ-ASELGMTSAFYKYI 266

  Fly   228 FTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPY---LNLHIKKST 289
            .|:.|.....|:....:..||..|.:.:|:                |.|...:   ||:..:::.
Mouse   267 LTTMDFPILHLDGIVEDSSNILGFSMFNTS----------------HPFYPEFVRSLNMSWRENC 315

  Fly   290 ILESEP------ALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKG 348
            ...:.|      |||||:|:|....::.|.:|..:.:..::|...|.|..|.||:|||..||:.|
Mouse   316 EASTYPGPALSAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDG 380

  Fly   349 LTGPIQFKD-GQRVQFKLDLIKLKQHSIVKVGEWTPHGHL--NITEPSMFFDAGSMNVTLVVITI 410
            |||.::|.. |||..:.|.:::..:....::|.|..:..|  |.|...:.......|.||||.||
Mouse   381 LTGRVEFNSKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLDINLSQTLANKTLVVTTI 445

  Fly   411 LETPYVMMHYGKNF---TGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGM 472
            ||.||||..  .||   :|||||.|||||:|..::..:.|.|.|.||.|..|||.:| .|.|.||
Mouse   446 LENPYVMRR--PNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEP-NGSWTGM 507

  Fly   473 VAQLM-KYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWI 536
            |.:|: :.||||||.:.|||..||.||||:||||.||||||::|........|||::|.:..:|:
Mouse   508 VGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPAVWL 572

  Fly   537 YVLIAYFLVSLCIYIVGKLSPIEW----KCINACD--LENISIGNQFSLTDSFWFTIGTFMQQSP 595
            ::|:||..||..:::..:|||.||    .|:.|..  ||     ||::|.:|.||.:|.||||..
Mouse   573 FMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILE-----NQYTLGNSLWFPVGGFMQQGS 632

  Fly   596 DIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGS 660
            :|.|||:|||.:|..|..|:|||::|||||||||||.:||..|:|:|:|||.||.|.|||:.:||
Mouse   633 EIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEYGTIHAGS 697

  Fly   661 TMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQ 725
            |||||::|..:||:::|..|.:|:||.|..:.|:||.||....||||:||||.:|..:.:|||||
Mouse   698 TMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTMNEYHRRLNCNLTQ 762

  Fly   726 IGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANS 790
            ||||||||||||..|.|||:||:|:||||:|||...:::|..|||:.  ..|.::   :..:|..
Mouse   763 IGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEG--GRCPKE---EDHRAKG 822

  Fly   791 LGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPD 855
            ||:|:|||:|||||.|:|:|..||..||.::.|.:.|   |:.|
Mouse   823 LGMENIGGIFVVLICGLIIAVFVAVMEFIWSTRRSAE---SEEV--------------------- 863

  Fly   856 RSFWIEIAEELRYASWC-----MNKQKRP 879
             |...|:.:|||:|..|     ..:::||
Mouse   864 -SVCQEMLQELRHAVSCRKTSRSRRRRRP 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	99/415 (24%)
		ANF_receptor	39..371	CDD:279440	92/381 (24%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	200/378 (53%)
		Lig_chan	533..807	CDD:278489	142/279 (51%)
Grik5	XP_030098003.1	PBP1_iGluR_Kainate_KA1_2	23..424	CDD:380616	99/418 (24%)
Grik5	XP_030098003.1	Periplasmic_Binding_Protein_Type_2	437..808	CDD:419667	200/378 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846689
Domainoid	1	1.000	362	1.000	Domainoid score	I943
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.710