DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and Grik1

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_006522977.1	Gene:	Grik1 / 14805	MGIID:	95814	Length:	949	Species:	Mus musculus

Alignment Length:	944	Identity:	369/944 - (39%)
Similarity:	555/944 - (58%)	Gaps:	87/944 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SGFLLFQFLSYGL--GVPPLVRIGAIF---SNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYY 64
            :.:.|..||.|.|  ..|.::|||.||   .|:| :...||||::|:..:|.:::|:|.||:.|.
Mouse    17 TSWTLLYFLCYILPQTSPQVLRIGGIFETVENEP-VNVEELAFKFAVTSINRNRTLMPNTTLTYD 80

  Fly    65 VEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNI-GRSAHD------- 121
            ::.:|.|||||..::.|..:.:||.|:|.|:.|...:.:.|||:||::|:| .|..|.
Mouse    81 IQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNRDL 145

  Fly   122 FSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRS---FHGEVHMRQV---SR 180
            |.||:||....::.|..|::.|.||....:::|...|:|.|.:|.::   ::.::.:||:   ::
Mouse   146 FYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNK 210

  Fly   181 DSYVSALNEFKGKEIHNIIIDTNSNGISILLKNIL-QQQMNEYKYHYLFTSFDLETYDLEDFKYN 244
            |:........||||.: :|.|.:....:.:||.|| ...|.|| |||.||:.||...|||.::|:
Mouse   211 DAKPLLKEMKKGKEFY-VIFDCSHETAAEILKQILFMGMMTEY-YHYFFTTLDLFALDLELYRYS 273

  Fly   245 FVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGL 309
            .||:|.|||::..:..|..|::...:.......:|...|   ...::.:|.|||:|:||:.||..
Mouse   274 GVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGL---LDGVMTTEAALMYDAVYMVAIAS 335

  Fly   310 QTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK--DGQRVQFKLDLIKLKQ 372
            ....|   ||:.::.|.....|..|...:|.:....|.||||.|.|.  ||.|..|.||:|.||:
Mouse   336 HRASQ---LTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGRITFNKTDGLRKDFDLDIISLKE 397

  Fly   373 HSI---------------VKVGEWTPHGHLNITEPSMFFDAGS------MNVTLVVITILETPYV 416
            ...               .|:|.|..:..||:|:.:.  |..:      .|.||:|.||||.|||
Mouse   398 EGTEKASGEVSKHLYKVWKKIGIWNSNSGLNMTDGNR--DRSNNITDSLANRTLIVTTILEEPYV 460

  Fly   417 MMHYG-KNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYK 480
            |.... |...||:||.|:|:|:|:.:|..:||.|.:.||||.||||:: :.|||||||.:|:.::
Mouse   461 MYRKSDKPLYGNDRFEGYCLDLLKELSNILGFLYDVKLVPDGKYGAQN-DKGEWNGMVKELIDHR 524

  Fly   481 ADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLV 545
            |||||..:||||.||.||||:||||.||||||::.|......:|||:|||:.:||:|||:|...|
Mouse   525 ADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGV 589

  Fly   546 SLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISST 610
            |..::::.:.:|.||...:.|:.::..:.|.|:|.:||||.:|..|||..::.|:|:||||:...
Mouse   590 SCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGI 654

  Fly   611 WGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKK 675
            |.||:|||::|||||||||||.|||.:||::|:|||.||:|.||.:..|||||||:.|.|.||:|
Mouse   655 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEK 719

  Fly   676 IWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATP 740
            :|..|.:::.||.....::||:||...:||.|||||.::|:.||:|||||||||:|:||||:.||
Mouse   720 MWAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTP 784

  Fly   741 KGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIA 805
            .|||:||||::|||:|||.|.:.|:.:|||:...  |..:::   .:|::||:|:|||:|:||.|
Mouse   785 IGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG--CPEEDS---KEASALGVENIGGIFIVLAA 844

  Fly   806 GIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQDG--------ILESERNYTPPDRSFWIE- 861
            |::::..||..||.|..|           .||...|.|        .....|.:.....|..:|
Mouse   845 GLVLSVFVAIGEFIYKSR-----------KNNDIEQKGKSSRLRFYFRNKVRFHGSKTESLGVEK 898

  Fly   862 ------IAEELRYASWCMNKQKRPALTRTCSKCT 889
                  |.|||..:.....|.|:.:.|:..|..|
Mouse   899 CLSFNAIMEELGISLKNQKKLKKKSRTKGKSSFT 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	127/398 (32%)
		ANF_receptor	39..371	CDD:279440	115/348 (33%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	196/369 (53%)
		Lig_chan	533..807	CDD:278489	136/273 (50%)
Grik1	XP_006522977.1	PBP1_iGluR_Kainate	38..431	CDD:380605	129/401 (32%)
Grik1	XP_006522977.1	Periplasmic_Binding_Protein_Type_2	446..815	CDD:389745	196/369 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846570
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68992
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.710