DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ekar and Grid2

DIOPT Version :9

Sequence 1:NP_001036250.1 Gene:Ekar / 43806 FlyBaseID:FBgn0039916 Length:899 Species:Drosophila melanogaster
Sequence 2:NP_032193.1 Gene:Grid2 / 14804 MGIID:95813 Length:1007 Species:Mus musculus


Alignment Length:892 Identity:244/892 - (27%)
Similarity:440/892 - (49%) Gaps:112/892 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 FLLFQFLSYGLG-------VPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYY 64
            |.|..|||:...       ...::.||||| ::....:.|: ||.|:..||.::.:|....:.:.
Mouse     4 FPLLLFLSFCWSRTWDLATADSIIHIGAIF-DESAKKDDEV-FRTAVGDLNQNEEILQTEKITFS 66

  Fly    65 VEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPN--IGRSA-------- 119
            |.:|:..:.|:.||:.|:|:..|:.|:.|......|..:.|:.||:.||:  |.||.        
Mouse    67 VTFVDGNNPFQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGC 131

  Fly   120 --------HDFSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQL--SRSFHG-EV 173
                    .|::::|.|...|.......|.:|. |.:|.|.::.|..|..:.:.  ..|..| :|
Mouse   132 GLTRSNRNDDYTLSVRPPVYLNEVILRVVTEYA-WQKFIIFYDSEYDIRGIQEFLDKVSQQGMDV 195

  Fly   174 HMRQVSRD-----------SYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYL 227
            .:::|..:           ..:..||.:: ..:...|:..|.......:..:::..:..:..|::
Mouse   196 ALQKVENNINKMITTLFDTMRIEELNRYR-DTLRRAILVMNPATAKSFISEVVETNLVAFDCHWI 259

  Fly   228 FTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTI-- 290
            ..:.::...|:::            || ...:|...|::.......:|.::.:...|...|::  
Mouse   260 IINEEINDVDVQE------------LV-RRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSSLCD 311

  Fly   291 --------LESEPALMFDSVYVFAIGL-QTLEQSHSLTLLNISCEEENS--WDGGLSLINYLNAV 344
                    :|.....::|:|.:.|... :.||.....::.::||..:||  |.||.|::..:...
Mouse   312 PKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKG 376

  Fly   345 EWKGLTGPIQF-KDGQRVQFKLDLIKLKQ-----HSIVKVGEWTPHGHLNITEPSMFFDAGSMNV 403
            ...||||.::| ::|.......:::....     ..:.|:|.|.|...||.:......:.....|
Mouse   377 GVNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRGV 441

  Fly   404 TLVVITILETPYVMMHYGKNFTGN-ERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETG 467
            .|.|:|:||.|:||:  .:|..|. :::.||.:|:|:.:|..:||:|.:.:.||.|||:.. |.|
Mouse   442 VLRVVTVLEEPFVMV--SENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQ-EDG 503

  Fly   468 EWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPT-RLFSFMNPLA 531
            .|||:|.:|:..:||:.:.::|||..||:|:|||..:|:..:.:|.:  .:|.| .:|:.:.|..
Mouse   504 TWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR--RAEKTVDMFACLAPFD 566

  Fly   532 IEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLT--DSFWFTIGTFMQQS 594
            :.:|..:.....||.|.:|::..|:|           ..:.:|:..|.|  :|.||..|:|:||.
Mouse   567 LSLWACIAGTVLLVGLLVYLLNWLNP-----------PRLQMGSMTSTTLYNSMWFVYGSFVQQG 620

  Fly   595 PDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGT-LDS 658
            .::....::||::...|..|:||:::|||||||||||..|:.:.|::.:||:.||:|.||| |||
Mouse   621 GEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLDS 685

  Fly   659 G--------STMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYED--GIKRVNQGNYAFLMESTML 713
            .        ....|.|||:   |.::|| |.|:...:.....|.  ||::|..|||||:.::.:|
Mouse   686 AVYQHVRMKGLNPFERDSM---YSQMWR-MINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVL 746

  Fly   714 DYIV--QRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDET 776
            :|:.  ..||:...:|..:..:|||||...|||:||..|..|||||:.||:.:|..|||....:.
Mouse   747 EYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPKNGQC 811

  Fly   777 CTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFR 823
            ....:...:.|..:|.::|:.|||.:|.|||:::.::|..|.|::.|
Mouse   812 DLYSSVDAKQKGGALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRR 858

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
EkarNP_001036250.1 PBP1_iGluR_Kainate 24..388 CDD:107377 83/414 (20%)
ANF_receptor 39..371 CDD:279440 74/377 (20%)
PBP2_iGluR_Kainate 402..771 CDD:270432 139/385 (36%)
Lig_chan 533..807 CDD:278489 100/288 (35%)
Grid2NP_032193.1 Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424 24..345 65/337 (19%)
Periplasmic_Binding_Protein_type1 28..429 CDD:385651 85/417 (20%)
PBP2_iGluR_delta_2 440..806 CDD:270449 139/385 (36%)
Interaction with AP4M1. /evidence=ECO:0000250|UniProtKB:Q63226 921..991
PDZ-binding 1005..1007
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1052
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000021
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR18966
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.910

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