Protein Alignment Ekar and Grik4

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: NP_780690.2
• Gene: Grik4 / 110637
• MGIID: 95817
• Length: 956
• Species: Mus musculus
• Alignment Length: 920
• Identity: 338/920 - (36%)
• Similarity: 502/920 - (54%)
• Gaps: 106/920 - (11%)

  Fly    20 PPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQKVCKL 83
            |..:||.||..:.......| |:...|.:|:|.....|.:..|:..:..:.|...:||.:.:|::
Mouse    22 PHSLRIAAILDDPMECSRGERLSITLAKNRINRAPERLGKAKVEVDIFELLRDSEYETAETMCQI 86

  Fly    84 IRVGVQAVFSPTDSVLATH-INSICDALDIPNIGRSAHDF---------SINVYPSKQLVNYAFN 138
            :..||.||..|:.|..::. |::||...::|:...:..:|         ::|::||...::.|..
Mouse    87 LPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKVAPEEFVRFQLQRFTTLNLHPSNTDISVAVA 151

  Fly   139 DVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHMRQVSRDSYVSALNEFKGKEIHNI 198
            .::.:.|.|...::..|...::||.:|.|.|     ...|.|...:||. ...|.|.:..:...|
Mouse   152 GILNFFNCTTACLICAKAECLLNLEKLLRQFLISKDTLSVRMLDDTRDP-TPLLKEIRDDKTATI 215

  Fly   199 IIDTN-SNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTADVGVK 262
            ||..| |...:||||......::.| |.|:||:.:.....::....:.|||..|.:.:.:....:
Mouse   216 IIHANASMSHTILLKAAELGMVSAY-YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQ 279

  Fly   263 QILKDIGL-----YSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQTLEQSHSLTLLN 322
            :..:.:..     ..|..|..|.|:            .||:||:||.....:|.|.:|..:.:..
Mouse   280 EFSQSLNQSWQENCDHVPFTGPALS------------SALLFDAVYAVVTAVQELNRSQEIGVKP 332

  Fly   323 ISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLKQHSIVKVGEWTPHGH 386
            :||.....|..|.||:|||..||.:||||.|:|.. |||..:.|.:::..::...::|:|    |
Mouse   333 LSCGSAQIWQHGTSLMNYLRMVELEGLTGHIEFNSKGQRSNYALKILQFTRNGFQQIGQW----H 393

  Fly   387 L-------------NITEPSMFFDAGSMNVTLVVITILETPYVMM---HYGKNFTGNERFYGFCV 435
            :             ||:: |:|      |.||||.||||.||:|:   |  :...||:|:.||||
Mouse   394 VAEGLSMDSRLYASNISD-SLF------NTTLVVTTILENPYLMLKGNH--QEMEGNDRYEGFCV 449

  Fly   436 DILETISREVGFDYILDLVPDRKYGAKDPE-TGEWNGMVAQLMKYKADLAVGSMTITYARESVID 499
            |:|:.::..:.|:|.:.||.|..||.  || .|.|.|||.:|:..||||||..:|||..||.|||
Mouse   450 DMLKELAEILRFNYKIRLVGDGVYGV--PEANGTWTGMVGELIARKADLAVAGLTITAEREKVID 512

  Fly   500 FTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEW---- 560
            |:||||.||||||::|........|||::|.:..:|:::|:||..||..:::|.:|:|.||
Mouse   513 FSKPFMTLGISILYRVHMGRRPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPH 577

  Fly   561 KCINA-CDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTA 624
            .|... |:|    :.||:||.:|.||.:|.||||...|.|||:|||.:|..|..|:|||::||||
Mouse   578 PCAQGRCNL----LVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTA 638

  Fly   625 NLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFT 689
            |||||||.:||..|||:.:|||.||.|.|||:..||:||||::|..:||:::|..|.:|:||.|.
Mouse   639 NLAAFLTVQRMEVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFV 703

  Fly   690 TTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAIL 754
            .:.|:||.||...|||||:||||.:|..||:|||||||||||||||||..|.||.:||:..||||
Mouse   704 KSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAIL 768

  Fly   755 ELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFW 819
            :|||...:::|..|||:.  ..|.::   :..:|..||:|:|||:|||||.|:|||..:|..||.
Mouse   769 QLQENNRLEILKRKWWEG--GKCPKE---EDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFL 828

  Fly   820 YNFRYN--YEATPSQSVVNNKYN----QDGILESERNY--TPPDRSFWIEIAEELRYASWCMNKQ 876
            :..|::  .|.:..|.:|....|    ||.|....|..  .||..    .:.||
Mouse   829 WTLRHSEASEVSVCQEMVTELRNIILCQDNIHPRRRRSGGLPPQP----PVLEE----------- 878

  Fly   877 KRPALTRTCS 886
            :||..|.|.|
Mouse   879 RRPRGTATLS 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	100/401 (25%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	195/377 (52%)
		Lig_chan	532..806	CDD:459656	142/278 (51%)
Grik4	NP_780690.2	Periplasmic_Binding_Protein_type1	24..402	CDD:471960	99/395 (25%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	195/377 (52%)
		QRL_CxxC_CxxC	863..927	CDD:469521	10/41 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956