Protein Alignment Ekar and grik5

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_002936446.1
• Gene: grik5 / 100497490
• XenbaseID: XB-GENE-953974
• Length: 995
• Species: Xenopus tropicalis
• Alignment Length: 905
• Identity: 324/905 - (35%)
• Similarity: 493/905 - (54%)
• Gaps: 79/905 - (8%)

  Fly     8 LLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYVEYVNRF 71
            ||..|.|.|:.:...:|:.||..:|......| ||...|...:|..........|:..:..:.:.
 Frog    13 LLLSFTSPGVSLLSSLRVAAILDDQTVCGRGERLALALAREHINSHTQGSASGRVEVEIFELQKD 77

  Fly    72 DSFETVQKVCKLIRVGVQAVFSP-TDSVLATHINSICDALDIPNIGRSAHD---------FSINV 126
            ..:||...:|:::..||.:|..| |....|:.::.||...:||:|.....:         .|:::
 Frog    78 SQYETTDTMCQILPKGVVSVLGPSTSPASASTVSHICGEKEIPHIKVGPEEAPKLQYLRFASVSL 142

  Fly   127 YPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSF-----HGEVHMRQVSRDSYVSA 186
            |||.:.::.|.:.:::..:.....::..|...::.|.:|.|.|     ...|.|...|.|. ...
 Frog   143 YPSNEDISLAVSHILKSFHNPSTSLICAKAECLLRLEELVRQFLISKDTLSVRMLDESNDP-TPL 206

  Fly   187 LNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSF 251
            |.|.:..::..||||.|:....::||...:..|....|.|:.|:.|.....||....:..||..|
 Frog   207 LKEIRDDKVSTIIIDANATVSHLILKKASELGMTSAHYKYILTTMDFPLLSLEGIVSDQSNILGF 271

  Fly   252 RLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILES------EPALMFDSVYVFAIGLQ 310
            .:.:::.....:.|:.             ||:..:::..|.:      ..|||||:|:|....::
 Frog   272 SMYNSSHPFYLEFLRS-------------LNMSWRENCELSTYLGPALSAALMFDAVHVVVSAVR 323

  Fly   311 TLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLDLIKLKQHS 374
            .|.:|..:.:..:||.....|..|.||:|||..||:.||||.::|.. |||..:.|.:::.....
 Frog   324 ELNRSQEIGVKQLSCSTSQIWQHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTNYTLRILEKAGDG 388

  Fly   375 IVKVGEWTPHGHLNITEPSMFFDAGSM--NVTLVVITILETPYVM--MHYGKNFTGNERFYGFCV 435
            ..::|.|..:..|.:...|:.......  |.||||.||||.||:|  .:| ::.:||:::.|||.
 Frog   389 HREIGVWYSNRTLAMNATSLDLSTSETLENKTLVVTTILENPYMMRKSNY-RSLSGNDQYEGFCA 452

  Fly   436 DILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDF 500
            ::|..::..:.|:|.:.||.|..|||.:| .|.|.|||.:|:..||||||.:.|||..||.||||
 Frog   453 EMLMELAALLRFNYKIKLVEDGLYGAPEP-NGSWTGMVGELINRKADLAVAAFTITAEREKVIDF 516

  Fly   501 TKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWKCINA 565
            :||||.||||||::|........|||::|.:..:|:::|:||..||..:::..:|||.||...:.
 Frog   517 SKPFMTLGISILYRVQMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHP 581

  Fly   566 CDLENISI-GNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAF 629
            |..|...| .||::|.:|.||.:|.||||..::.|||:|||.:|..|..|:|||::|||||||||
 Frog   582 CLRERHHILENQYTLGNSLWFPVGGFMQQGSEVMPRALSTRCVSGVWWAFTLIIISSYTANLAAF 646

  Fly   630 LTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYED 694
            ||.:||..|||:|:|||.||.|.|||:..|||||||::|..:||:::|..|::|:||.|..:.|:
 Frog   647 LTVQRMEVPIESADDLADQTNIEYGTIHGGSTMTFFQNSRYQTYQRMWNYMNSKQPSVFVKSTEE 711

  Fly   695 GIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKGSPWRDKISLAILELQER 759
            ||.||....||||:||||.:|..:.:|||||||||||||||||..|.|||:||:|:||||:|||.
 Frog   712 GIARVLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPYRDEITLAILQLQEN 776

  Fly   760 GDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFEFWYNFRY 824
            ..:::|..|||:.  ..|.::   :..:|..||:|:|||:|||||.|:|:|..||..||.::.|
 Frog   777 NRLEILKRKWWEG--GKCPKE---EDHRAKGLGMENIGGIFVVLICGLIIAVFVAIMEFVWSTR- 835

  Fly   825 NYEATPSQSVVNNKYNQDGILESERNYTPPDRSFWIEIAEELRYASWC-----MNKQKRP 879
                   :||.|.:.                 |...|:..|||.|..|     ...::||
 Frog   836 -------RSVDNEEI-----------------SVCQEMLSELRSAVSCKKTSRSRHRRRP 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	93/388 (24%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	191/371 (51%)
		Lig_chan	532..806	CDD:459656	141/274 (51%)
grik5	XP_002936446.1	PBP1_iGluR_Kainate_KA1_2	27..405	CDD:380616	93/391 (24%)
		Periplasmic_Binding_Protein_Type_2	418..788	CDD:473866	191/371 (51%)