Protein Alignment Ekar and grin3b

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_017952374.2
• Gene: grin3b / 100497172
• XenbaseID: XB-GENE-990106
• Length: 1005
• Species: Xenopus tropicalis
• Alignment Length: 1039
• Identity: 226/1039 - (21%)
• Similarity: 383/1039 - (36%)
• Gaps: 275/1039 - (26%)

  Fly    23 VRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVEYVNRFDSFETVQK-VCK-LIR 85
            ||:||:.   |...:::...:..:.|::. .|.||.......|....|..|..::.: :|: |:.
 Frog    37 VRLGALL---PSYGHTQARIQNVLSRISR-TSWLPYNLSLEVVSGAPRDRSPASLTRWLCQVLVA 97

  Fly    86 VGVQAVFS-PTDSVLATHINSICDALDIPNIGRSAHDFSINVYPSKQLVNYA------------- 136
            .|:.||.: |........:..:...|:||         .|::...:|:|..|
 Frog    98 QGIAAVLAFPQAQEELLQLEFLSSFLEIP---------FISILEQEQIVPLATKNPFHLQMDTQS 153

  Fly   137 --------FNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVSRDSYVSALNEFKGK 193
                    |..|:|..:|        :|..||..|...          ..|...|:::......:
 Frog   154 SVENLMDIFFSVLQNSSW--------EEVDIITCHPWD----------SASIQRYLTSNTTLVSR 200

  Fly   194 EIHNI-IIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSFRLVDTA 257
            .|.|| .:|.::      |...|||.....|.    ..|.:..|..:..:.:.|    ||
 Frog   201 TILNIHPVDESA------LVPFLQQHFESMKN----PQFPMLLYGCDARRSSLV----FR----- 246

  Fly   258 DVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALM---------FDSVYVFAIGLQTLE 313
                  :.:|.||.:|.........|:.::.|.....|.|:         .:.....|:||.|..
 Frog   247 ------VARDCGLEAHEFHWMIGHPLNGEEMTTEGMPPGLLAYGEVSRPTMEKFIRDAVGLVTRA 305

  Fly   314 QSHS------LTLLN--ISCEE---ENSWDGGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDL 367
            .|.:      |.|:.  ::|.:   :.:...|..|..:|....:.|.||.|...:        :|
 Frog   306 ISAAVHVRPDLALIQSMVNCNDKQTKQNESSGSYLSRFLANTSFSGQTGQIYVSN--------NL 362

  Fly   368 IKLKQH----SIVK----------VGEWTPHGHLNIT-----------EPSMFFDAGSMNVTLVV 407
            |..:.|    |:|:          ||.|. .|.:.:.           ||:   ..|.....|.|
 Frog   363 IHTEHHYRIWSLVRDSLGDPTWVTVGGWR-QGKMEVEEGLWQSRIQQWEPA---PGGFARTKLRV 423

  Fly   408 ITILETPYVMMH---------YGKNF----TGNERF-----------------------YGFCVD 436
            :|::|.|:|...         .|:..    |.|...                       ||:|:|
 Frog   424 VTLVEHPFVFTREVDADGSCPAGQMCLDPRTNNSAVLDVLFEELNSPNGSVPLEYKTCCYGYCID 488

  Fly   437 ILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFT 501
            :||.:|.::.||:.|.:|.|.||||:..:  .|.|:|..|:...|.:||.|.:|..||.:|||||
 Frog   489 LLEKLSEDLRFDFELYIVGDGKYGARKGD--RWTGLVGDLLSGAAHMAVTSFSINSARSTVIDFT 551

  Fly   502 KPFMNLGISILFKV-PTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKLSPIEWK---- 561
            .||.:..:.||.:: .|:.|  :.:||.||...:|:.:.:|..:.:|.      |:..|||
 Frog   552 SPFYSTSLGILVRMRDTASP--IGAFMWPLHWSMWVGIFVALHITALF------LTFYEWKSPFG 608

  Fly   562 ----------------CINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISST 610
                            .:|.|                :....|..:....   |:..:.|::.:.
 Frog   609 MTPHGRNRTKIFSYSSALNLC----------------YAILFGRTVSSKT---PKCCTGRVLMNL 654

  Fly   611 WGFFSLIIVASYTANLAAFLTTERMINPIENAED--LASQTE-ISYGTLDSGSTMTFFRDSVIET 672
            |..|.|::::||||||||.:..::....:....|  |...:: ..:||:        :..|..:.
 Frog   655 WAIFCLLVLSSYTANLAAVMVGDKTFEALSGIHDPKLHHPSQGFRFGTV--------WESSAEQY 711

  Fly   673 YKKIWRSMDNKKPSAFTTTYEDGIKRVNQGN---YAFLMESTMLDY--IVQRDCNLTQIGGLLDT 732
            .||.:..|.|...........||:..:....   .||:|:..:|||  .:..||.|..||.....
 Frog   712 IKKSFPEMHNYMRKFSVPATSDGVHLLKTDPPTLNAFIMDKALLDYEVSIDSDCKLLTIGKPFAI 776

  Fly   733 KGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIG 797
            :||||..|:.||....||..|...:..|.:..|:|||:|..  .| .|.....::...:|:....
 Frog   777 EGYGIGLPQNSPLTSNISEFISRYKSSGFMDTLHDKWYKMV--PC-GKRVYAVTETLQMGIYHFS 838

  Fly   798 GVFVVLIAGIIVAAVVAFFE-FWYNF---------RYNYEATPSQSV-------------VNNKY 839
            |:||:|..|...:.:.:..| ..|:.         |:.|....||.:             ::.|.
 Frog   839 GLFVLLCIGFCGSLLTSLMERVVYHLILPRIRRRRRFKYWLHTSQKIHRALNMTCEDQDALSPKL 903

  Fly   840 NQDGILESERNYTPPDRSFWIEI----AEELRYASWCMNKQKRPALTRTCSKCTIPKGQRINKL 899
            |:...|:.:....|  :|.|..:    |.:.|...:  |.:|..|....|.... |||.:..:|
 Frog   904 NKRCNLQKDATGAP--QSVWNNLRRTPAHQERRVHF--NLEKASAREGLCENGR-PKGIKQEEL 962

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	80/424 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	111/433 (26%)
		Lig_chan	532..806	CDD:459656	68/301 (23%)
grin3b	XP_017952374.2	PBP1_iGluR_NMDA_NR3	29..402	CDD:380600	81/429 (19%)
		PBP2_iGluR_NMDA_Nr3	418..814	CDD:270438	110/432 (25%)
		Lig_chan	580..847	CDD:459656	68/302 (23%)