DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and grik1

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_004912220.1	Gene:	grik1 / 100493949	XenbaseID:	XB-GENE-957124	Length:	928	Species:	Xenopus tropicalis

Alignment Length:	863	Identity:	344/863 - (39%)
Similarity:	530/863 - (61%)	Gaps:	60/863 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLFQFLSYGLGVPP-----LVRIGAIF---SNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYY 64
            ||..||.....:.|     ::|||.||   .|:| :...||||::|:..:|.:::|:|.||:.|.
Frog    25 LLLPFLCALAAITPQASQQVLRIGGIFETVENEP-INVEELAFKFAVTNINRNRTLMPNTTLTYD 88

  Fly    65 VEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNI-GRSAH-------D 121
            ::.:|.|||||..::.|..:.:||.|:|.|:.|...:.:.|||:||::|:| .|..|       .
Frog    89 IQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTRWKHPSVDNKDS 153

  Fly   122 FSINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRS---FHGEVHMRQV---SR 180
            |.||::|....::.|..:::.:.:|....:::|...|:|.|.:|.::   ::.::.:||:   ::
Frog   154 FFINLHPDYAAISRAVLELVLHYSWKTVTVVYEDSTGLIRLQELIKAPSRYNIKIKIRQLPSGNK 218

  Fly   181 DSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQ-QMNEYKYHYLFTSFDLETYDLEDFKYN 244
            |:. :.|.|.|......:|.|.:....:.:||.||.. .|.|| |||.||:.||...|||.::|:
Frog   219 DAR-TLLKEMKKSREFYVIFDCSHETAAEILKQILSMGMMTEY-YHYFFTTMDLFALDLEPYRYS 281

  Fly   245 FVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGL 309
            .||:|.|||::..:..|..:::...:.......||...|   ...::.::.|||:|:||:.|:..
Frog   282 GVNMTGFRLLNIDNPQVSSVVEKWSMERLQAPPKPETGL---LDGMMTTDAALMYDAVYMVAVAT 343

  Fly   310 QTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFK--DGQRVQFKLDLIKLKQ 372
            |...|   :|:.::.|.....|..|...::.:....|.||||.|.|.  ||.|..|.:|:|.||:
Frog   344 QRATQ---MTVSSLQCHRHKPWRFGPRFMSLIKEARWDGLTGRITFNRTDGLRRDFDMDIISLKE 405

  Fly   373 HSI---------------VKVGEWTPHGHLNIT----EPSMFFDAGSMNVTLVVITILETPYVMM 418
            ..:               .|||.|..:..||:|    :.|........|.||:|.||||.||||.
Frog   406 DGMEKAAGETVNHLNKVWKKVGVWNSNTGLNMTDNLKDKSTNITDSLANRTLIVTTILEDPYVMF 470

  Fly   419 HYG-KNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKAD 482
            ... |...||:||.|:|:|:|:.:|..:||.|.:.||.|.||||:: :.|||||||.:|:.:|||
Frog   471 RKSDKPLYGNDRFEGYCLDLLKELSNILGFTYEVRLVVDGKYGAQN-DKGEWNGMVRELIDHKAD 534

  Fly   483 LAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSL 547
            |||..:||||.||.||||:||||.||||||::.|......:|||:|||:.:||:|||:|...||.
Frog   535 LAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSC 599

  Fly   548 CIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTWG 612
            .::::.:.:|.||...:.|:.::..:.|.|:|.:||||.:|..|||..::.|:|:||||:...|.
Frog   600 VLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWW 664

  Fly   613 FFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKIW 677
            ||:|||::|||||||||||.|||.:||::|:|||.||:|.||.:..|||||||:.|.|.||:|:|
Frog   665 FFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMW 729

  Fly   678 RSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDTKGYGIATPKG 742
            ..|.:::.:|.....::||:||...:||.|||||.::|:.||:|||||||||:|:||||:.||.|
Frog   730 AFMSSRQQTALVKNNDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIG 794

  Fly   743 SPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGI 807
            ||:||||::|||:|||.|.:.|:.:|||:...  |..:::   .:|::||:|:|||:|:||.||:
Frog   795 SPYRDKITIAILQLQEEGKLHMMKEKWWRGNG--CPEEDS---KEASALGVENIGGIFIVLAAGL 854

  Fly   808 IVAAVVAFFEFWYNFRYN 825
            :::..||..||.|..|.|
Frog   855 VLSVFVAIGEFIYKSRKN 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	119/398 (30%)
		ANF_receptor	39..371	CDD:279440	106/348 (30%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	195/369 (53%)
		Lig_chan	533..807	CDD:278489	135/273 (49%)
grik1	XP_004912220.1	Periplasmic_Binding_Protein_Type_1	43..438	CDD:299141	121/403 (30%)
		ANF_receptor	61..404	CDD:279440	106/350 (30%)
		Periplasmic_Binding_Protein_Type_2	454..823	CDD:304360	195/369 (53%)
		Lig_chan	585..854	CDD:278489	135/273 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	361	1.000	Domainoid score	I951
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H68992
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010