Protein Alignment Ekar and grik4

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_031761990.1
• Gene: grik4 / 100490768
• XenbaseID: XB-GENE-1011875
• Length: 962
• Species: Xenopus tropicalis
• Alignment Length: 871
• Identity: 314/871 - (36%)
• Similarity: 477/871 - (54%)
• Gaps: 88/871 - (10%)

  Fly     2 LIASGFLLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYV 65
            ::|...|:..:|....|.|.| ||.||..:.......| |:...|.:|:|.......:..::..:
 Frog     4 VLAPMVLVLLWLMKSAGSPSL-RIAAILDDPMECSRGERLSITLAKNRINRAPERQGKARLEVDI 67

  Fly    66 EYVNRFDSFETVQKVCKLIRVGVQAV----FSPTDSVLATHINSICDALDIPNIGRSAHDF---- 122
            ..:.:...:||.:.:|:::..||..|    :||:.|.:   |::||...::|:|..|..:|
 Frog    68 FELLKDSEYETAETMCQILPKGVLGVLGPSYSPSSSSI---ISNICGEKEVPHIKVSTEEFLRFQ 129

  Fly   123 -----SINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVSRDS 182
                 ::|::||...::.|...::::.|.|...::..|...::||.:|.|.|       .:|:|.
 Frog   130 YQRFTTLNLHPSNTDISAAVATLLRFFNSTTACLICAKAECLLNLEKLLRQF-------LISKDC 187

  Fly   183 Y-----------VSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETY 236
            .           ...|.|.:..:...||:..|::....:|....:..|....|.|:||:.:....
 Frog   188 LSVRMLDDTWDPTPLLKEIRDDKTSTIIVHANASMSHTILMKAAELGMVTAYYTYIFTNLEFVLQ 252

  Fly   237 DLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEP------ 295
            ..|....:.|||..|.:.:               .||..||:....|........:..|
 Frog   253 RFESPLDDRVNILGFSMFN---------------QSHSYFKEFAHTLQQSWEENCDHSPFTGPAL 302

  Fly   296 --ALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD- 357
              ||:||:||.....:|.|.:|..:.:..:||.....|..|.||:|||..||.:||||.::|..
 Frog   303 SAALLFDAVYGIVSAVQELNRSQEIGVKPLSCGSSQIWQHGTSLMNYLRMVELEGLTGHVEFNSK 367

  Fly   358 GQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMFFDAGS----MNVTLVVITIL----ETP 414
            |||..:.:.:::..:....::|:|.....||:.:  .:|...:    :|.||:|.|||    |.|
 Frog   368 GQRSNYDMKIMQYTKTGFQEIGQWHVTNGLNMDK--RYFSPNASDTLVNKTLIVTTILFFLQENP 430

  Fly   415 YVMMHYG-KNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPE-TGEWNGMVAQLM 477
            |:|:... :...||:|:.|||||:|:.::..:.|:|.:.||.|..||.  || .|.|.|||.:|:
 Frog   431 YLMLKANHQELEGNDRYEGFCVDMLKELAAILRFNYKIRLVADGVYGV--PELNGTWTGMVGELI 493

  Fly   478 KYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAY 542
            ..||||||..:|||..||.||||:||||.||||||::|........|||::|.:..:|:::|:||
 Frog   494 SRKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAY 558

  Fly   543 FLVSLCIYIVGKLSPIEW----KCINA-CDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAM 602
            ..||..:::|.:|:|.||    .|... |:|    :.||:||.:|.||.:|.||||...|.|||:
 Frog   559 LAVSCVLFLVARLTPYEWYSPHPCAQGRCNL----LVNQYSLGNSLWFPVGGFMQQGSTIAPRAL 619

  Fly   603 STRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRD 667
            |||.:|..|..|:|||::|||||||||||.:||..|||:.:|||.||.|.|||:..||:||||::
 Frog   620 STRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTTIEYGTIHGGSSMTFFQN 684

  Fly   668 SVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDT 732
            |..:||:::|..|.:|:||.|..:.|:||.||...|||||:||||.:|..||:|||||:||||||
 Frog   685 SRYQTYQRMWNYMHSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQVGGLLDT 749

  Fly   733 KGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIG 797
            |||||..|.||.:||:..||||:|||...::.|..|||..  ..|.::   :..:|..||:|:||
 Frog   750 KGYGIGMPVGSAFRDEFDLAILQLQENNCLEDLKRKWWDG--GKCPKE---EDHRAKGLGMENIG 809

  Fly   798 GVFVVLIAGIIVAAVVAFFEFWYNFR 823
            |:|||||.|:|||.::|..||.:..|
 Frog   810 GIFVVLICGLIVAILIAMLEFLWTVR 835

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	93/399 (23%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	192/379 (51%)
		Lig_chan	532..806	CDD:459656	141/278 (51%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:471960	94/402 (23%)
		PBP2_iGluR_kainate_KA1	414..788	CDD:270442	192/379 (51%)