DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and grik4

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_031761990.1	Gene:	grik4 / 100490768	XenbaseID:	XB-GENE-1011875	Length:	962	Species:	Xenopus tropicalis

Alignment Length:	871	Identity:	314/871 - (36%)
Similarity:	477/871 - (54%)	Gaps:	88/871 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LIASGFLLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSE-LAFRYAIHRLNMDKSLLPETTVDYYV 65
            ::|...|:..:|....|.|.| ||.||..:.......| |:...|.:|:|.......:..::..:
Frog     4 VLAPMVLVLLWLMKSAGSPSL-RIAAILDDPMECSRGERLSITLAKNRINRAPERQGKARLEVDI 67

  Fly    66 EYVNRFDSFETVQKVCKLIRVGVQAV----FSPTDSVLATHINSICDALDIPNIGRSAHDF---- 122
            ..:.:...:||.:.:|:::..||..|    :||:.|.:   |::||...::|:|..|..:|
Frog    68 FELLKDSEYETAETMCQILPKGVLGVLGPSYSPSSSSI---ISNICGEKEVPHIKVSTEEFLRFQ 129

  Fly   123 -----SINVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVSRDS 182
                 ::|::||...::.|...::::.|.|...::..|...::||.:|.|.|       .:|:|.
Frog   130 YQRFTTLNLHPSNTDISAAVATLLRFFNSTTACLICAKAECLLNLEKLLRQF-------LISKDC 187

  Fly   183 Y-----------VSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETY 236
            .           ...|.|.:..:...||:..|::....:|....:..|....|.|:||:.:....
Frog   188 LSVRMLDDTWDPTPLLKEIRDDKTSTIIVHANASMSHTILMKAAELGMVTAYYTYIFTNLEFVLQ 252

  Fly   237 DLEDFKYNFVNITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEP------ 295
            ..|....:.|||..|.:.:               .||..||:....|........:..|
Frog   253 RFESPLDDRVNILGFSMFN---------------QSHSYFKEFAHTLQQSWEENCDHSPFTGPAL 302

  Fly   296 --ALMFDSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGLSLINYLNAVEWKGLTGPIQFKD- 357
              ||:||:||.....:|.|.:|..:.:..:||.....|..|.||:|||..||.:||||.::|..
Frog   303 SAALLFDAVYGIVSAVQELNRSQEIGVKPLSCGSSQIWQHGTSLMNYLRMVELEGLTGHVEFNSK 367

  Fly   358 GQRVQFKLDLIKLKQHSIVKVGEWTPHGHLNITEPSMFFDAGS----MNVTLVVITIL----ETP 414
            |||..:.:.:::..:....::|:|.....||:.:  .:|...:    :|.||:|.|||    |.|
Frog   368 GQRSNYDMKIMQYTKTGFQEIGQWHVTNGLNMDK--RYFSPNASDTLVNKTLIVTTILFFLQENP 430

  Fly   415 YVMMHYG-KNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPE-TGEWNGMVAQLM 477
            |:|:... :...||:|:.|||||:|:.::..:.|:|.:.||.|..||.  || .|.|.|||.:|:
Frog   431 YLMLKANHQELEGNDRYEGFCVDMLKELAAILRFNYKIRLVADGVYGV--PELNGTWTGMVGELI 493

  Fly   478 KYKADLAVGSMTITYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAY 542
            ..||||||..:|||..||.||||:||||.||||||::|........|||::|.:..:|:::|:||
Frog   494 SRKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAY 558

  Fly   543 FLVSLCIYIVGKLSPIEW----KCINA-CDLENISIGNQFSLTDSFWFTIGTFMQQSPDIYPRAM 602
            ..||..:::|.:|:|.||    .|... |:|    :.||:||.:|.||.:|.||||...|.|||:
Frog   559 LAVSCVLFLVARLTPYEWYSPHPCAQGRCNL----LVNQYSLGNSLWFPVGGFMQQGSTIAPRAL 619

  Fly   603 STRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRD 667
            |||.:|..|..|:|||::|||||||||||.:||..|||:.:|||.||.|.|||:..||:||||::
Frog   620 STRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTTIEYGTIHGGSSMTFFQN 684

  Fly   668 SVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGGLLDT 732
            |..:||:::|..|.:|:||.|..:.|:||.||...|||||:||||.:|..||:|||||:||||||
Frog   685 SRYQTYQRMWNYMHSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQRNCNLTQVGGLLDT 749

  Fly   733 KGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIG 797
            |||||..|.||.:||:..||||:|||...::.|..|||..  ..|.::   :..:|..||:|:||
Frog   750 KGYGIGMPVGSAFRDEFDLAILQLQENNCLEDLKRKWWDG--GKCPKE---EDHRAKGLGMENIG 809

  Fly   798 GVFVVLIAGIIVAAVVAFFEFWYNFR 823
            |:|||||.|:|||.::|..||.:..|
Frog   810 GIFVVLICGLIVAILIAMLEFLWTVR 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	91/397 (23%)
		ANF_receptor	39..371	CDD:279440	85/365 (23%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	192/379 (51%)
		Lig_chan	533..807	CDD:278489	141/278 (51%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:415822	94/402 (23%)
grik4	XP_031761990.1	PBP2_iGluR_kainate_KA1	414..788	CDD:270442	192/379 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910