DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and grin2cb

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_009305071.2	Gene:	grin2cb / 100333648	ZFINID:	ZDB-GENE-100308-2	Length:	1328	Species:	Danio rerio

Alignment Length:	953	Identity:	222/953 - (23%)
Similarity:	371/953 - (38%)	Gaps:	258/953 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVE------ 66
            ||| |....|.|.|..| |..|...|.: |..:.|..:.|...:...|.||..:|..:|
Zfish    14 LLF-FFHLLLNVVPRCR-GRPFFGPPSV-NVAVVFSGSAHHSEIKGRLSPENFLDMPLEVNPITV 75

  Fly    67 YVNRFDSFETVQKVCKLIRV----GVQAVF-SPTDS-VLATHINSICDALDIPNIGRSAHDFSIN 125
            .||..:....:.::|:.:..    ||  || ...|| .:|..::.:.....||.:|.|..  |..
Zfish    76 LVNDTNPRALLTRLCQTMAAESLHGV--VFEDDVDSEAVAQILDFVSSQTSIPIVGISGG--SAV 136

  Fly   126 VYPSK--------------QLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMR 176
            |.|.|              |.:|..|. |::..||..|.::.....|........|||
Zfish   137 VIPHKADGSTFLQMGASIDQQINAMFK-VMEEYNWGNFVVITSLYPGYETFVDYIRSF------- 193

  Fly   177 QVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKY---------HYLF-TSF 231
              :..||..       .|:.:::....|.|.:.:....|.||::...|         .||| .:.
Zfish   194 --TDTSYFL-------WELQDVLSFEMSVGANDIRTRRLLQQVDSQVYLVYCSHEEAQYLFRMAS 249

  Fly   232 DL-------------------ETYDLEDFKYNFVNITSFR----LVDTADVGVKQILKDIGLYSH 273
            |:                   |......|....::|.:.|    |......||..|:|  |::|.
Zfish   250 DVGLLGPGYIWIVPSLAVGNPEAAPPASFPVGVISIITDRWRKTLRQRVREGVAIIVK--GVHSF 312

  Fly   274 HIFK--------------KPYLN-------LHIK---KSTILESEPALMFDSVYVFAIGLQTLEQ 314
            |..:              |.|.|       |::.   |.....|:..|...|:.:.|:
Zfish   313 HKHRGFIPEGHSDCSSPVKSYANNSLFRHMLNVSWEHKDLSFNSDGYLTNPSMVIIAL------- 370

  Fly   315 SHSLTLLNISCEEENSWD------GGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQH 373
                       :.||.||      ||:..:.|           |:
Zfish   371 -----------DRENHWDKVGSYEGGILQMRY-----------PV-------------------- 393

  Fly   374 SIVKVGEWTPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMM-------------------- 418
                   |..:|        .|.:..|.|..|.|.|:.|.|:|::
Zfish   394 -------WPRYG--------SFLEPVSDNRHLTVATLEERPFVIVESVDPATGTCVRNTVPCRRQ 443

  Fly   419 -HYGKNFTGNERFY------GFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQL 476
             :..::..|:...|      |||:|||:.:||.:.|.|.|.||.:.|:|..  ..|.||||:.::
Zfish   444 SNRTESIIGHTEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHGKM--VRGVWNGMIGEV 506

  Fly   477 MKYKADLAVGSMTITYARESVIDFTKPFMNLGISILF--KVPTSEPTRLFSFMNPLAIEIWIYVL 539
            ...:||:|:||:||...|..::||:.||:..|||::.  ...|..|:   :|:.|.:..:|:.:.
Zfish   507 FYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS---AFLEPYSPAVWVMMF 568

  Fly   540 I-AYFLVSLCIYIVGKLSPIEWKCINACDLENISI-------GNQFSLTDSFWFTIG-TFMQQSP 595
            : ...:|::.:::....||:.:         |.|:       |..|::..|.|...| .|....|
Zfish   569 VMCLTVVAVTVFVFEYFSPVGY---------NRSLVSAKAPGGPTFTIGKSVWLLWGIVFNNSVP 624

  Fly   596 DIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQ------TEISYG 654
            ...|:..:::|:...|.||::|.:||||||||||:..|:.|:.:....|...|      ....:|
Zfish   625 IENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQEHYPPFRFG 689

  Fly   655 TLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNY-AFLMESTMLDYIVQ 718
            |:.:|||....|.:..:.:..:.:.  |:|      ..|:.:..:..|.. ||:.::.:|:|:..
Zfish   690 TVPNGSTERNIRSNYPDMHTHMIKY--NQK------GVEEALNSLKTGKLDAFIYDAAVLNYMAG 746

  Fly   719 RD--CNLTQIGG--LLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTR 779
            :|  |.|..||.  :..|.|||||..|.|.|:..|.||:|:....||.|.|...|...   .|
Zfish   747 KDEGCKLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWLSG---IC-- 806

  Fly   780 KNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFE---FW 819
            :|...:..::.|.::::.|||.:|:..:.::.:|..:|   :|
Zfish   807 QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYW 849

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	85/452 (19%)
		ANF_receptor	39..371	CDD:279440	78/420 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	118/417 (28%)
		Lig_chan	533..807	CDD:278489	77/293 (26%)
grin2cb	XP_009305071.2	PBP1_iGluR_NMDA_NR2	37..396	CDD:107373	81/438 (18%)
		PBP2_iGluR_NMDA_Nr2	407..808	CDD:270436	119/427 (28%)
		NMDAR2_C	845..>932	CDD:313729	1/5 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591861
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740