Protein Alignment Ekar and grin2cb

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_009305071.3
• Gene: grin2cb / 100333648
• ZFINID: ZDB-GENE-100308-2
• Length: 1328
• Species: Danio rerio
• Alignment Length: 953
• Identity: 222/953 - (23%)
• Similarity: 371/953 - (38%)
• Gaps: 258/953 - (27%)

  Fly     8 LLFQFLSYGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDYYVE------ 66
            ||| |....|.|.|..| |..|...|.: |..:.|..:.|...:...|.||..:|..:|
Zfish    14 LLF-FFHLLLNVVPRCR-GRPFFGPPSV-NVAVVFSGSAHHSEIKGRLSPENFLDMPLEVNPITV 75

  Fly    67 YVNRFDSFETVQKVCKLIRV----GVQAVF-SPTDS-VLATHINSICDALDIPNIGRSAHDFSIN 125
            .||..:....:.::|:.:..    ||  || ...|| .:|..::.:.....||.:|.|..  |..
Zfish    76 LVNDTNPRALLTRLCQTMAAESLHGV--VFEDDVDSEAVAQILDFVSSQTSIPIVGISGG--SAV 136

  Fly   126 VYPSK--------------QLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMR 176
            |.|.|              |.:|..|. |::..||..|.::.....|........|||
Zfish   137 VIPHKADGSTFLQMGASIDQQINAMFK-VMEEYNWGNFVVITSLYPGYETFVDYIRSF------- 193

  Fly   177 QVSRDSYVSALNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKY---------HYLF-TSF 231
              :..||..       .|:.:::....|.|.:.:....|.||::...|         .||| .:.
Zfish   194 --TDTSYFL-------WELQDVLSFEMSVGANDIRTRRLLQQVDSQVYLVYCSHEEAQYLFRMAS 249

  Fly   232 DL-------------------ETYDLEDFKYNFVNITSFR----LVDTADVGVKQILKDIGLYSH 273
            |:                   |......|....::|.:.|    |......||..|:|  |::|.
Zfish   250 DVGLLGPGYIWIVPSLAVGNPEAAPPASFPVGVISIITDRWRKTLRQRVREGVAIIVK--GVHSF 312

  Fly   274 HIFK--------------KPYLN-------LHIK---KSTILESEPALMFDSVYVFAIGLQTLEQ 314
            |..:              |.|.|       |::.   |.....|:..|...|:.:.|:
Zfish   313 HKHRGFIPEGHSDCSSPVKSYANNSLFRHMLNVSWEHKDLSFNSDGYLTNPSMVIIAL------- 370

  Fly   315 SHSLTLLNISCEEENSWD------GGLSLINYLNAVEWKGLTGPIQFKDGQRVQFKLDLIKLKQH 373
                       :.||.||      ||:..:.|           |:
Zfish   371 -----------DRENHWDKVGSYEGGILQMRY-----------PV-------------------- 393

  Fly   374 SIVKVGEWTPHGHLNITEPSMFFDAGSMNVTLVVITILETPYVMM-------------------- 418
                   |..:|        .|.:..|.|..|.|.|:.|.|:|::
Zfish   394 -------WPRYG--------SFLEPVSDNRHLTVATLEERPFVIVESVDPATGTCVRNTVPCRRQ 443

  Fly   419 -HYGKNFTGNERFY------GFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQL 476
             :..::..|:...|      |||:|||:.:||.:.|.|.|.||.:.|:|..  ..|.||||:.::
Zfish   444 SNRTESIIGHTEPYTKLCCKGFCIDILKKLSRTIKFSYDLYLVTNGKHGKM--VRGVWNGMIGEV 506

  Fly   477 MKYKADLAVGSMTITYARESVIDFTKPFMNLGISILF--KVPTSEPTRLFSFMNPLAIEIWIYVL 539
            ...:||:|:||:||...|..::||:.||:..|||::.  ...|..|:   :|:.|.:..:|:.:.
Zfish   507 FYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS---AFLEPYSPAVWVMMF 568

  Fly   540 I-AYFLVSLCIYIVGKLSPIEWKCINACDLENISI-------GNQFSLTDSFWFTIG-TFMQQSP 595
            : ...:|::.:::....||:.:         |.|:       |..|::..|.|...| .|....|
Zfish   569 VMCLTVVAVTVFVFEYFSPVGY---------NRSLVSAKAPGGPTFTIGKSVWLLWGIVFNNSVP 624

  Fly   596 DIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQ------TEISYG 654
            ...|:..:::|:...|.||::|.:||||||||||:..|:.|:.:....|...|      ....:|
Zfish   625 IENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQEHYPPFRFG 689

  Fly   655 TLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNY-AFLMESTMLDYIVQ 718
            |:.:|||....|.:..:.:..:.:.  |:|      ..|:.:..:..|.. ||:.::.:|:|:..
Zfish   690 TVPNGSTERNIRSNYPDMHTHMIKY--NQK------GVEEALNSLKTGKLDAFIYDAAVLNYMAG 746

  Fly   719 RD--CNLTQIGG--LLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTR 779
            :|  |.|..||.  :..|.|||||..|.|.|:..|.||:|:....||.|.|...|...   .|
Zfish   747 KDEGCKLVTIGSGKVFATTGYGIALQKDSRWKRPIDLALLQFLGDGDTQRLETVWLSG---IC-- 806

  Fly   780 KNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFFE---FW 819
            :|...:..::.|.::::.|||.:|:..:.::.:|..:|   :|
Zfish   807 QNEKNEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLLYW 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	85/454 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	118/417 (28%)
		Lig_chan	532..806	CDD:459656	77/293 (26%)
grin2cb	XP_009305071.3	None