DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and si:dkey-183j2.10

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_001923977.1	Gene:	si:dkey-183j2.10 / 100151589	ZFINID:	ZDB-GENE-130530-729	Length:	465	Species:	Danio rerio

Alignment Length:	452	Identity:	161/452 - (35%)
Similarity:	257/452 - (56%)	Gaps:	38/452 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   405 LVVITILETPYVMMHYGKNFTGNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEW 469
            |:|.||.:.||.|       :...:..|:|:|:|..:::::||.|.:.||.|..||.:| |.|.|
Zfish    31 LIVTTIKQDPYTM-------SKGSQLEGYCMDLLTELAKKLGFKYKVHLVKDGSYGRQD-ENGNW 87

  Fly   470 NGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILF-KVPTSEPTRLFSFMNPLAIE 533
            |||:.::::.:|||||..:|:|.|||..:..|||:|..|||||. |...||....|.|::|.:.|
Zfish    88 NGMIGEVVRGEADLAVAPLTLTAAREKAVGMTKPYMQTGISILLRKDIVSEEAGFFDFLSPFSGE 152

  Fly   534 IWIYVLIAYFLVSLCIYIVGKLSPIEWKCINACDLENISIGNQFSLTDSFWFTIGTFMQQSPDIY 598
            .|..:|||||:.::||.|||:|||.||.       :..:..|.|:|..|.|:|.|....|....:
Zfish   153 TWFGILIAYFVTAVCICIVGRLSPCEWS-------QPETEPNHFTLLHSLWYTAGALSLQGAGPH 210

  Fly   599 PRAMSTRIISSTWGFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMT 663
            |:|:|.|:||.||..|:::::|.|.::|::...::.....|:..||||:|..|.||||...||:.
Zfish   211 PKAVSGRVISCTWWLFAVVLLACYFSSLSSTQGSDSAPLMIKGFEDLANQDVIEYGTLAGSSTLA 275

  Fly   664 FFRDSVIETYKKIWRSMDNKKPSAFTTTYEDGIKRVNQGNYAFLMESTMLDYIVQRDCNLTQIGG 728
            ||::|...:|::|:..|:.:|  :|.::.::|:::..:|||||:.||..||..|.|.|.|.:...
Zfish   276 FFKNSNNPSYRRIYEHMERRK--SFVSSMDEGVQKAKEGNYAFIGESVSLDLAVARHCELVRAHE 338

  Fly   729 LLDTKGYGIATPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGL 793
            ::..:||.|.||.||.....:|:|||:|.|.|::..|..|||.:   :|...|    :||:||..
Zfish   339 VIGMRGYSIVTPLGSAMLKNLSVAILQLSEAGELAYLRTKWWAS---SCLPDN----AKASSLRA 396

  Fly   794 ESIGGVFVVLIAGIIVAAVVAFFEFWYNFR-------------YNYEATPSQSVVNNKYNQD 842
            .|:.|:|:||..|:.:..:::.||.....|             ...|.:....:.|.|.:||
Zfish   397 HSMKGIFLVLAIGLGIGVLLSLFELTTKSRSAAGEQKKSCCTVLTQELSQRLRMTNTKRDQD 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377
		ANF_receptor	39..371	CDD:279440
		PBP2_iGluR_Kainate	402..771	CDD:270432	140/366 (38%)
		Lig_chan	533..807	CDD:278489	101/273 (37%)
si:dkey-183j2.10	XP_001923977.1	PBP2_iGluR_non_NMDA_like	28..381	CDD:270403	140/366 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.910