Protein Alignment Ekar and grin2db

DIOPT Version :10

• Sequence 1: NP_001036250.1
• Gene: Ekar / 43806
• FlyBaseID: FBgn0039916
• Length: 899
• Species: Drosophila melanogaster
• Sequence 2: XP_073782035.1
• Gene: grin2db / 100149482
• ZFINID: ZDB-GENE-100920-7
• Length: 1984
• Species: Danio rerio
• Alignment Length: 745
• Identity: 183/745 - (24%)
• Similarity: 316/745 - (42%)
• Gaps: 177/745 - (23%)

  Fly   233 LETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDI-GLYSHHIF---KKPYLNLH-------IK 286
            ||.||.          |:|.:|.|...|.:..|..: ||......   ||..:.|:       ::
Zfish   215 LEEYDW----------TAFSVVSTRHHGYQDFLSVVEGLTDGSFIGWEKKSIVMLNLTDDPGGVR 269

  Fly   287 KSTIL---ESEPALMF------DSVYVFAIGLQTLEQSH-------SLTLLNIS-------CEEE 328
            ...:|   |::..|::      :.|::.|........||       :|:.|.::       ....
Zfish   270 TQRLLKENEAQVRLLYCSQEEAEQVFLAAWAAGQAGASHIWFAVGPALSELGLTGLPKRLFAVRP 334

  Fly   329 NSWDG--------GLSLINYLNAVEWK---GLTGPIQF-----KDGQRVQ--------------- 362
            ..|..        |:|::.: .||..:   |.||...|     .||.|.|
Zfish   335 QGWRDEPRRRIARGVSILTH-GAVALRKDYGATGGPHFVTNCQTDGNRTQRIRGRMRYFSNITLG 398

  Fly   363 -----FK---------LDLIKLKQHSIVKVGEWTPHGHLNITEPSM-----FFDAGSMNVTLVVI 408
                 |.         ||:|.....|..:...|..:|.|.:..|:.     |.........|.|:
Zfish   399 GRDYSFSNEGYLANPFLDVISYTPGSGWEDVGWWENGVLRLRYPAWSRYGPFLQPPDDAQHLRVV 463

  Fly   409 TILETPYVMMHYGKNFTG-------------------------NERFYGFCVDILETISREVGFD 448
            |:.|.|:|::......:|                         .:...|||:|||:.::|.|||.
Zfish   464 TLEERPFVIVELADAASGTCIRDSVPCRRPLNASALQEGVAPVKQCCKGFCIDILKRLARIVGFT 528

  Fly   449 YILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILF 513
            |.|.||.:.|:|.|  ..|.|||||.:::..:||:|:||:||...|..|:||:.||:..|||::.
Zfish   529 YDLYLVTNGKHGKK--IDGVWNGMVGEVVYKRADMAIGSLTINEERSEVVDFSVPFVETGISVMV 591

  Fly   514 KVP--TSEPTRLFSFMNPLAIEIWIYVLI-AYFLVSLCIYIVGKLSPIEWKCINACDLENISI-- 573
            ...  |..|:   :|:.|.:..:|:.:.: ...:|::.::|....||:.:         |.|:
Zfish   592 SRSNGTVSPS---AFLEPYSPAVWVMMFVMCLTVVAVTVFIFEFFSPVGY---------NRSLQS 644

  Fly   574 -----GNQFSLTDSFWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTT 632
                 |::|::..|.|.... .|....|...|:..:::|:...|.||::|.:||||||||||:..
Zfish   645 GKKAGGSKFTIGKSIWLLWALVFNNSVPVENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQ 709

  Fly   633 ERMINPIENAEDLASQ--TE----ISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTT 691
            |..|:.:....|...|  ||    :.:||:.:|||....|.:..:.::.:.:.  |:|      :
Zfish   710 EEYIDTVSGLSDKKFQHPTEQYPPLKFGTVPNGSTEKNIRSNYPDMHQYMVKY--NQK------S 766

  Fly   692 YEDGIKRVNQGNY-AFLMESTMLDYIVQRD--CNLTQIGG--LLDTKGYGIATPKGSPWRDKISL 751
            .||.|..:..|.. ||:.::.:|:|:.::|  |.:..||.  :..|.|||||..|.|.|:..:.|
Zfish   767 VEDAISHLKTGKLDAFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGIALIKNSRWKRPLDL 831

  Fly   752 AILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFF 816
            |:|:|....:|:||...|...   .|  .|...:..::.|.::::.|||.:|:..:.::.:|..:
Zfish   832 ALLQLVGDDEIEMLERLWLSG---IC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAW 891

  Fly   817 EFWYNFRYNYEATPSQSVVNNKYNQDGILE 846
            |....:|..:        ..:|..|.|.|:
Zfish   892 EHLVYWRLRH--------CMSKMGQSGKLD 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..390	CDD:380605	45/235 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	122/415 (29%)
		Lig_chan	532..806	CDD:459656	79/293 (27%)
grin2db	XP_073782035.1	None