DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and LOC100149482

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_009290417.1	Gene:	LOC100149482 / 100149482	-ID:	-	Length:	1959	Species:	Danio rerio

Alignment Length:	745	Identity:	183/745 - (24%)
Similarity:	316/745 - (42%)	Gaps:	177/745 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   233 LETYDLEDFKYNFVNITSFRLVDTADVGVKQILKDI-GLYSHHIF---KKPYLNLH-------IK 286
            ||.||.          |:|.:|.|...|.:..|..: ||......   ||..:.|:       ::
Zfish   190 LEEYDW----------TAFSVVSTRHHGYQDFLSVVEGLTDGSFIGWEKKSIVMLNLTDDPGGVR 244

  Fly   287 KSTIL---ESEPALMF------DSVYVFAIGLQTLEQSH-------SLTLLNIS-------CEEE 328
            ...:|   |::..|::      :.|::.|........||       :|:.|.::       ....
Zfish   245 TQRLLKENEAQVRLLYCSQEEAEQVFLAAWAAGQAGASHIWFAVGPALSELGLTGLPKRLFAVRP 309

  Fly   329 NSWDG--------GLSLINYLNAVEWK---GLTGPIQF-----KDGQRVQ--------------- 362
            ..|..        |:|::.: .||..:   |.||...|     .||.|.|
Zfish   310 QGWRDEPRRRIARGVSILTH-GAVALRKDYGATGGPHFVTNCQTDGNRTQRIRGRMRYFSNITLG 373

  Fly   363 -----FK---------LDLIKLKQHSIVKVGEWTPHGHLNITEPSM-----FFDAGSMNVTLVVI 408
                 |.         ||:|.....|..:...|..:|.|.:..|:.     |.........|.|:
Zfish   374 GRDYSFSNEGYLANPFLDVISYTPGSGWEDVGWWENGVLRLRYPAWSRYGPFLQPPDDAQHLRVV 438

  Fly   409 TILETPYVMMHYGKNFTG-------------------------NERFYGFCVDILETISREVGFD 448
            |:.|.|:|::......:|                         .:...|||:|||:.::|.|||.
Zfish   439 TLEERPFVIVELADAASGTCIRDSVPCRRPLNASALQEGVAPVKQCCKGFCIDILKRLARIVGFT 503

  Fly   449 YILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFTKPFMNLGISILF 513
            |.|.||.:.|:|.|  ..|.|||||.:::..:||:|:||:||...|..|:||:.||:..|||::.
Zfish   504 YDLYLVTNGKHGKK--IDGVWNGMVGEVVYKRADMAIGSLTINEERSEVVDFSVPFVETGISVMV 566

  Fly   514 KVP--TSEPTRLFSFMNPLAIEIWIYVLI-AYFLVSLCIYIVGKLSPIEWKCINACDLENISI-- 573
            ...  |..|:   :|:.|.:..:|:.:.: ...:|::.::|....||:.:         |.|:
Zfish   567 SRSNGTVSPS---AFLEPYSPAVWVMMFVMCLTVVAVTVFIFEFFSPVGY---------NRSLQS 619

  Fly   574 -----GNQFSLTDSFWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTANLAAFLTT 632
                 |::|::..|.|.... .|....|...|:..:::|:...|.||::|.:||||||||||:..
Zfish   620 GKKAGGSKFTIGKSIWLLWALVFNNSVPVENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQ 684

  Fly   633 ERMINPIENAEDLASQ--TE----ISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKKPSAFTTT 691
            |..|:.:....|...|  ||    :.:||:.:|||....|.:..:.::.:.:.  |:|      :
Zfish   685 EEYIDTVSGLSDKKFQHPTEQYPPLKFGTVPNGSTEKNIRSNYPDMHQYMVKY--NQK------S 741

  Fly   692 YEDGIKRVNQGNY-AFLMESTMLDYIVQRD--CNLTQIGG--LLDTKGYGIATPKGSPWRDKISL 751
            .||.|..:..|.. ||:.::.:|:|:.::|  |.:..||.  :..|.|||||..|.|.|:..:.|
Zfish   742 VEDAISHLKTGKLDAFIYDAAVLNYMARKDEGCKVMTIGSGKVFATTGYGIALIKNSRWKRPLDL 806

  Fly   752 AILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIVAAVVAFF 816
            |:|:|....:|:||...|...   .|  .|...:..::.|.::::.|||.:|:..:.::.:|..:
Zfish   807 ALLQLVGDDEIEMLERLWLSG---IC--HNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAW 866

  Fly   817 EFWYNFRYNYEATPSQSVVNNKYNQDGILE 846
            |....:|..:        ..:|..|.|.|:
Zfish   867 EHLVYWRLRH--------CMSKMGQSGKLD 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	44/233 (19%)
		ANF_receptor	39..371	CDD:279440	41/216 (19%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	122/415 (29%)
		Lig_chan	533..807	CDD:278489	79/293 (27%)
LOC100149482	XP_009290417.1	PBP1_iGluR_NMDA_NR2	44..421	CDD:107373	46/241 (19%)
		PBP2_iGluR_NMDA_Nr2	433..831	CDD:270436	123/424 (29%)
		HisJ	<487..>570	CDD:223904	39/84 (46%)
		Lig_chan	585..857	CDD:278489	79/293 (27%)
		NMDAR2_C	868..>900	CDD:287527	5/29 (17%)
		FAM76	<1763..>1856	CDD:292665
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810