DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ekar and gria1

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	XP_004912781.1	Gene:	gria1 / 100127569	XenbaseID:	XB-GENE-995621	Length:	903	Species:	Xenopus tropicalis

Alignment Length:	934	Identity:	330/934 - (35%)
Similarity:	496/934 - (53%)	Gaps:	114/934 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLIASGFLLFQFLSYGLGV--PPLVRIGAIFSNQPGMYNSELAFRYAIHRLNMDKSLLPETTVDY 63
            ||....:....||...|||  |..::||.:|.||....::  |||:|:.:|:....|||:
Frog     1 MLRIFAYFCTSFLGAVLGVNFPNHIQIGGLFPNQQSQEHA--AFRFALSQLSEPPKLLPQ----- 58

  Fly    64 YVEYVNRFDSFETVQKVCKLIRVGVQAVFSPTDSVLATHINSICDALDIPNIGRS-----AHDFS 123
             ::.||..||||.....|.....||.|:|...|......:.|.|.||.:..|..|     ::.|.
Frog    59 -IDIVNISDSFEMTYTFCSQFSKGVYAIFGFYDRKTVNMLTSFCGALHVCFITPSFPVATSNQFV 122

  Fly   124 INVYPSKQLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGE------VHMRQVSRDS 182
            :.:.|..|   .|...||:|..|.:|..:::.:.|:..|.::..:...:      |::...:.:.
Frog   123 LQLRPELQ---DALISVIEYYKWKKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEG 184

  Fly   183 YVSALNEFKGKEIHNIIIDTNSNGI-SILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFV 246
            |.....:....:...|:||..|..: :||.:.:::.:.|...|||:..:......|::.||....
Frog   185 YRLLFQDLDKSKDRQIVIDCESERLNAILTQVVVKLEKNIIGYHYILANLGFMDIDMQKFKEAGA 249

  Fly   247 NITSFRLVDTADVGVKQILKDIGLYSHHIFKKPYLNLHIKKSTILESEPALMFDSVYVFAIGLQT 311
            |:|.|:||:..|..|.:|::....|...  ::|.::....|.|     .||.:|.|.|.|...|:
Frog   250 NVTGFQLVNYTDTMVSRIMQQWKNYDGR--EQPRVDWKKPKYT-----SALTYDGVRVMAEAFQS 307

  Fly   312 LEQSHSLTLLNIS-------CEEENS--WDGGLSLINYLNAVEWKGLTGPIQFKD-GQRVQFKLD 366
            |.:..    ::||       |....:  |..|:.:...|..|..:||:|.:||.: |:|..:.|.
Frog   308 LRKQR----IDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRLEGLSGNVQFNEKGRRTNYTLH 368

  Fly   367 LIKLKQHSIVKVGEWTPHGHL--NITEPSMFFDA-GSMNVTLVVITILETPYVMMHYGKN---FT 425
            :::||...|..:..|.....|  ..|:.....|. |..|.|.:|.||||.||||:.  ||   ..
Frog   369 VLELKHEGIRHIAHWNEDDKLIPLATDAQAGNDTIGVQNRTYIVTTILEAPYVMLK--KNADQLE 431

  Fly   426 GNERFYGFCVDILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTI 490
            ||:||.|:||::...|::.|||.|.|::|.|.||||:|.:...|||||.:|:..:|||||..:||
Frog   432 GNDRFEGYCVELAAEIAKHVGFKYKLEIVKDGKYGARDSDMKAWNGMVGELVYGRADLAVAPLTI 496

  Fly   491 TYARESVIDFTKPFMNLGISILFKVPTSEPTRLFSFMNPLAIEIWIYVLIAYFLVSLCIYIVGKL 555
            |..||.||||:||||:|||||:.|.|......:|||::|||.|||:.::.||..||:.:::|.:.
Frog   497 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRF 561

  Fly   556 SPIEWKCINACDLENISIG---------NQFSLTDSFWFTIGTFMQQSPDIYPRAMSTRIISSTW 611
            ||.||      ..|....|         |:|.:.:|.||::|.||||..||.||::|.||:...|
Frog   562 SPYEW------HNEEFEEGKEQPTTDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVW 620

  Fly   612 GFFSLIIVASYTANLAAFLTTERMINPIENAEDLASQTEISYGTLDSGSTMTFFRDSVIETYKKI 676
            .||:|||::|||||||||||.|||::|||:|:|||.||||:|||||||||..||:.|.|..::|:
Frog   621 WFFTLIIISSYTANLAAFLTVERMVSPIESADDLAKQTEIAYGTLDSGSTKEFFKRSKIAVFEKM 685

  Fly   677 WRSMDNKKPSAFTTTYEDGIKRV--NQGNYAFLMESTMLDYIVQR-DCNLTQIGGLLDTKGYGIA 738
            |..|.:.:||.|..|.|:|:.||  ::|.||:|:||||.:||.|| .|:..::||.||:||||||
Frog   686 WTYMRSAEPSVFVKTTEEGMNRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIA 750

  Fly   739 TPKGSPWRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVL 803
            ||||||.|..::||:|:|.|:|.:..|..|||.:..| |..|::..:.|.::|.|.::.|||.:|
Frog   751 TPKGSPLRGAVNLAVLKLSEQGVLDKLKSKWWYDKGE-CGSKDSGSKDKTSALSLSNVAGVFYIL 814

  Fly   804 IAGIIVAAVVAFFEFWYNFRYNYEATPSQSVVNNKYNQDGILESERNYTPPDRSFWIEIAEELRY 868
            |.|:.:|.:||..||.|..|                                       :|..:.
Frog   815 IGGLGLAMLVALIEFCYKSR---------------------------------------SESKKM 840

  Fly   869 ASWCMNKQKRPALTRTCSKCTIPK 892
            ..:|:..|  ..:|.|....|:|:
Frog   841 KGFCLIPQ--TTVTETVRMATLPR 862

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	97/387 (25%)
		ANF_receptor	39..371	CDD:279440	87/353 (25%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	195/383 (51%)
		Lig_chan	533..807	CDD:278489	137/285 (48%)
gria1	XP_004912781.1	PBP1_iGluR_AMPA_GluR1	26..393	CDD:380613	97/388 (25%)
gria1	XP_004912781.1	PBP2_iGluR_AMPA_GluR1	407..788	CDD:270447	197/389 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000