DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ekar and grin2ca

DIOPT Version :9

Sequence 1:	NP_001036250.1	Gene:	Ekar / 43806	FlyBaseID:	FBgn0039916	Length:	899	Species:	Drosophila melanogaster
Sequence 2:	NP_001352716.1	Gene:	grin2ca / 100003342	ZFINID:	ZDB-GENE-070822-3	Length:	1400	Species:	Danio rerio

Alignment Length:	967	Identity:	221/967 - (22%)
Similarity:	391/967 - (40%)	Gaps:	232/967 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 YGLGVPPLVRIGAIFSNQPGMYNSELAFRYAIHR-LNMDKSLLPETTVDYYVEYVNRFDSFETVQ 78
            :|: |.|.|.:..:||.  ..|.:|:..|.:... |::...:.|.|.:      ||..:....:.
Zfish    33 FGM-VEPTVNVAVVFSG--SAYQTEIKGRLSRENFLDLPLEVNPITVL------VNNTNPRTLLT 88

  Fly    79 KVCKLI---RV-GVQAVFSPTDSVLATHINSICDALD----IPNIGRSAHDFSINVYPSK----- 130
            ::|..:   || ||  ||.  |::.:..:..|.|.:.    :|.:|.|..  |..|.|.|
Zfish    89 RICDTLAANRVHGV--VFE--DNIGSEAVAQILDFISTQTAVPIVGISGG--SAVVLPHKGDGST 147

  Fly   131 ---------QLVNYAFNDVIQYLNWTRFGILHEKENGIINLHQLSRSFHGEVHMRQVSRDSYVSA 186
                     |.:|..|. |::..||..|.::.....|.                     |:||..
Zfish   148 FLQLGSSIEQQINGMFK-VMEEYNWDSFVVVTSLYPGY---------------------DTYVDY 190

  Fly   187 LNEFKGKEIHNIIIDTNSNGISILLKNILQQQMNEYKYHYLFTSFDLETYDLEDFKYNFVNITSF 251
            :..|         |||:                     ::|:...|..|:|:.....|  ::.:.
Zfish   191 IRSF---------IDTS---------------------YFLWELQDTLTFDMSADGMN--DLRAR 223

  Fly   252 RLVDTADVGVK-------------QILKDIGLYS-HHIFKKPYLNLHIKKSTILESEPALMF--- 299
            ||:...|..|.             .:.:::||.. .:|:..|.|.:........:|.|..:.
Zfish   224 RLLQQIDAQVLLVYCSHDEAQYLFSMAREVGLVGPGYIWFIPSLAVGNPNIAPPDSFPVGLISII 288

  Fly   300 -------------DSVYVFAIGLQTLEQSHSLTLLNISCEEENSWDGGL------------SLIN 339
                         |.|.:...|:::..:......           ||.:            :|..
Zfish   289 TDRWKMSLRNRVRDGVAIVVKGVESFRKQRGFIP-----------DGHMDCLSPIRPASNGTLYR 342

  Fly   340 YLNAVEWKGLTGPIQFKDGQRVQFKLDLIKL-KQHSIVKVGEWTPHGHLNITEP-----SMFFDA 398
            ::..|.|:....... .||..|...:.:|.| :.....|||.: ..|.|.:..|     ..|.:.
Zfish   343 HMLNVSWENTDFSFN-SDGYLVNPSMIIITLDRGRQWDKVGNY-ESGILQMRYPVWPRYGTFLEP 405

  Fly   399 GSMNVTLVVITILETPYVMM---------------------HYGKNFTGNERFY------GFCVD 436
            .|.|..|.|.|:.|.|:|::                     :..:...|:...|      |||:|
Zfish   406 VSDNRHLTVATLEERPFVIVEAVDPVTGTCLSNTVPCRRQSNKTETIVGHTEPYTKLCCKGFCID 470

  Fly   437 ILETISREVGFDYILDLVPDRKYGAKDPETGEWNGMVAQLMKYKADLAVGSMTITYARESVIDFT 501
            ||:.:||.:.|.|.|.||.:.|:|..  ..|.||||:.::...:||:|:||:||...|..:|||:
Zfish   471 ILKKLSRNIKFSYDLYLVTNGKHGKL--VRGIWNGMIGEVFYKRADMAIGSLTINEERSEIIDFS 533

  Fly   502 KPFMNLGISILF--KVPTSEPTRLFSFMNPLAIEIWIYVLI-AYFLVSLCIYIVGKLSPIEW--K 561
            .||:..|||::.  ...|..|:   :|:.|.:..:|:.:.: ...:|::.:::....||:.:  .
Zfish   534 VPFVETGISVMVARSNGTVSPS---AFLEPYSPAVWVMMFVMCLTVVAVTVFVFEYCSPVGYNRS 595

  Fly   562 CINACDLENISIGNQFSLTDSFWFTIG-TFMQQSPDIYPRAMSTRIISSTWGFFSLIIVASYTAN 625
            .::|.|    ..|..|::..|.|...| .|....|...|:..:::|:...|.||::|.:||||||
Zfish   596 LVSAKD----PGGPTFTIGKSVWLLWGIVFNNSVPIENPKGTTSKIMVLVWAFFAVIFLASYTAN 656

  Fly   626 LAAFLTTERMINPIENAEDLASQ------TEISYGTLDSGSTMTFFRDSVIETYKKIWRSMDNKK 684
            ||||:..|:.|:.:....|...|      ....:||:.:|||....|.:..|.:..:.:.  |:|
Zfish   657 LAAFMIQEQYIDTVSGLSDKKFQKPQDQYPPFRFGTVPNGSTERNIRSNYPEMHSHMVKY--NQK 719

  Fly   685 PSAFTTTYEDGIKRVNQGNY-AFLMESTMLDYIVQRD--CNLTQIGG--LLDTKGYGIATPKGSP 744
                  ..||.:..:..|.. ||:.::.:|:|:..:|  |.|..||.  :..|.|||||..|.|.
Zfish   720 ------GVEDALNSLKTGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIALQKESR 778

  Fly   745 WRDKISLAILELQERGDIQMLYDKWWKNTDETCTRKNTSKQSKANSLGLESIGGVFVVLIAGIIV 809
            |:..|.||:|:....||.|.|...|.     |...:|..|:..::.|.::::.|||.:|:..:.:
Zfish   779 WKRPIDLALLQFLADGDTQKLQTVWL-----TGICRNEKKEVMSSKLDIDNMAGVFYMLLVAMGL 838

  Fly   810 AAVVAFFEFWYNFRYNYEATPSQSV---------VNNKYNQDGILESER--NYTPPD 855
            :.:|..:|....::..:....|:.:         :.:.:|  |:.:::|  |...||
Zfish   839 SLLVFAWEHLLYWKLRHSVRKSERLDFLLAISRGIYSCFN--GVEDTDRKGNMQNPD 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ekar	NP_001036250.1	PBP1_iGluR_Kainate	24..388	CDD:107377	75/429 (17%)
		ANF_receptor	39..371	CDD:279440	68/397 (17%)
		PBP2_iGluR_Kainate	402..771	CDD:270432	121/412 (29%)
		Lig_chan	533..807	CDD:278489	80/288 (28%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..398	CDD:107373	79/440 (18%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	122/422 (29%)
		NMDAR2_C	847..>938	CDD:313729	7/49 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740