Protein Alignment Gat and SLC6A5

DIOPT Version :9

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_004202.4
• Gene: SLC6A5 / 9152
• HGNCID: 11051
• Length: 797
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 265/591 - (44%)
• Similarity: 374/591 - (63%)
• Gaps: 23/591 - (3%)

  Fly    31 TSLQSSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGA 95
            ||:...|..|..|...:|   .::...||:||||:|||||:||.|:|||||||||||.::|||||
Human   167 TSVLPGSVATVATQEDEQ---GDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGA 228

  Fly    96 FILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAW 160
            |::||::.|.|||:|:||:|::|||..:.|.:.|:|..|..:|.|.|..::|..:.:||.||:.:
Human   229 FLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICY 293

  Fly   161 AVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKV-------CSVSALNI 218
            .:||.|.|..:.:||.:|||.|||..|    :.|.....|..:.....|:       |..:..|:
Human   294 TLFYLFASFVSVLPWGSCNNPWNTPEC----KDKTKLLLDSCVISDHPKIQIKNSTFCMTAYPNV 354

  Fly   219 TSLELTDPV--------KEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTG 275
            |.:..|...        :|:::...|:||.|||..|.|||.||..|.|.|::.|..:.||:|.:|
Human   355 TMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLALCLFLAWVIVYASLAKGIKTSG 419

  Fly   276 KVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGT 340
            |||||||.||||:|.|||:||:|||||..||.::|.|.:.|||::.||.||.||||||.....|.
Human   420 KVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGG 484

  Fly   341 LVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLV 405
            |:.|.|||||.||.|:|.|||...||:||:||||||||||||||:|::..:.:||..|||:||:|
Human   485 LITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVV 549

  Fly   406 YPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLRKRKEIFIAIVCALSY 470
            ||.|:.:||.||.|:.:||.|||.:|||:.|.|:|..:|:|.||:|:.||..|.:|....|...:
Human   550 YPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFF 614

  Fly   471 LVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWK 535
            ::|...|||||:|:||::|:||.| :.|:.:..||.|.||:.||:.||.:.|:.|||:.|.::||
Human   615 IMGFPMITQGGIYMFQLVDTYAAS-YALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWK 678

  Fly   536 FCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGE 600
            .||...||.|...:..|:..||.|:.|..|.||.|:...||.....|:::||:.........||.
Human   679 VCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMHLAPGR 743

  Fly   601 LSEKIR 606
            ..|:::
Human   744 FIERLK 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	259/564 (46%)
SLC6A5	NP_004202.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..118
		SLC6sbd_GlyT2	191..787	CDD:271389	259/564 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820