Protein Alignment Gat and Slc6a2

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_112633.2
• Gene: Slc6a2 / 83511
• RGDID: 621822
• Length: 617
• Species: Rattus norvegicus
• Alignment Length: 601
• Identity: 258/601 - (42%)
• Similarity: 370/601 - (61%)
• Gaps: 38/601 - (6%)

  Fly    22 EMSKELGHTTSL--QSSSPTTT------DTSNKQQLVKIEQLPD---RGSWSSKMDFILSVVGLA 75
            ::..|||....|  |...|..|      ...|..|.:...|..|   |.:|..|:||:|||||.|
  Rat     9 QVQPELGGADQLPEQPLRPCKTADLLVVKEHNGVQCLLASQDGDAQPRETWGKKIDFLLSVVGFA 73

  Fly    76 IGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFKIAPIFKGIG 140
            :.|.|||||||||||||||||::||.:.|.:||:|:|:|||||||....|...|:||.|.|||:|
  Rat    74 VDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVG 138

  Fly   141 YAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIING 205
            ||..:::.::..||.||:||:::|.|.|...::||..|.:.||:.||
  Rat   139 YAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNC------------------ 185

  Fly   206 TTQKVCSVSAL----NITSLELTDPVKEFWERRALQI--SHGIEEIGNIRWELAGTLLLVWILCY 264
            |..|:.:.|.|    ..:..:.| |..||:||..|.:  |.||.:||..:|:|...|::|.::.|
  Rat   186 TDPKLLNASVLGDHTKYSKYKFT-PAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLY 249

  Fly   265 FCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQ 329
            |.:|||||.:||||:.||..||.:|.:|||.|:|||||..||..|:..:|.:|..:.|||||.||
  Rat   250 FSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQ 314

  Fly   330 IFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADV 394
            ||||.|.|.|.|:|..|||||.||.|:|||:..|:|..||..:||.|||::|:||||.:..:.||
  Rat   315 IFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDV 379

  Fly   395 AASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLRKRKE 459
            |..|.||.|::||.|:..|.||..|:.|||.|||.:||||....||..||.:.|:: |:|::.::
  Rat   380 ATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDF-QVLKRHRK 443

  Fly   460 IFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKD 524
            :|...|...::|:.:.|||:||:|:..:||::| :|..:|:.:..|.:.:||.||||||.:.|:.
  Rat   444 LFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFA-AGTSILFAVLMEAIGVSWFYGVDRFSNDIQQ 507

  Fly   525 MIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALSSMLYIPLY 589
            |:|:.|.::|:.||...:||..|.|...:|:.:.|:.|.||.||.||:..||..|||||:.:|.|
  Rat   508 MMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAY 572

  Fly   590 MFWLWKRTPGELSEKI 605
            :.:.:....|.|.|::
  Rat   573 VIYKFFSIRGSLWERV 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	247/554 (45%)
Slc6a2	NP_112633.2	SLC5-6-like_sbd	56..615	CDD:444915	247/554 (45%)