DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and slc6a3

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_571830.1	Gene:	slc6a3 / 80787	ZFINID:	ZDB-GENE-010316-1	Length:	629	Species:	Danio rerio

Alignment Length:	578	Identity:	253/578 - (43%)
Similarity:	369/578 - (63%)	Gaps:	37/578 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIIT 103
            |.|..|.:|          |.:|..|:||:|||:|.|:.|.|||||||||||||||||::||::.
Zfish    67 THTHPSGQQ----------RETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLF 121

  Fly   104 LFLAGIPMFFMELALGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMS 168
            :.:||:|:|:|||||||....|..||:||.|||||:|:...::|.::..||.||:|||:||.|.|
Zfish   122 MVIAGMPLFYMELALGQYNREGAAGVWKICPIFKGVGFTVILISLYVGSYYNVIIAWALFYLFSS 186

  Fly   169 MRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWER 233
            ...::||..|||.||:.||...                     :.:.||.|  ..|.|..|::||
Zfish   187 FSGELPWIHCNNTWNSPNCSDP---------------------NATLLNDT--YKTTPALEYFER 228

  Fly   234 RALQI--SHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRG 296
            ..|.:  |.||:::|..||:|...|.:|.::.||.:|||||.:||||:.||..|||:||:||:||
Zfish   229 GVLHVHESSGIDDLGAPRWQLTACLAVVIVVLYFSLWKGVKTSGKVVWITATMPYVVLTVLLLRG 293

  Fly   297 ITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIV 361
            :|||||::|||.|:..:|.:|.:::|||:|.|||.||.|:|.|.|:|..|||||:||.|:||:|.
Zfish   294 VTLPGAIDGIKAYLSVDFLRLYDAQVWIEAATQICFSLGVGFGVLIAFSSYNKFSNNCYRDAIIT 358

  Fly   362 CTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFM 426
            .::||.||.|:||||||.:|:|:.:....:..||..||||.|::||.|:..||||.:|:.:||.|
Zfish   359 SSINSLTSFFSGFVIFSFLGYMSQKHNVALDKVATDGPGLVFIIYPEAIATLPGSSVWAVIFFIM 423

  Fly   427 LLLIGLDSQFCTMEGFITAIIDEWPQLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSY 491
            ||.:|:||....||..||.:|||: :.|.|.:|:|...:...::|:.|.|:|.||:|:|.:||.:
Zfish   424 LLTLGIDSAMGGMESVITGLIDEF-KFLHKHRELFTLFIVVSTFLISLICVTNGGIYVFTLLDHF 487

  Fly   492 AVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQ 556
            | :|..:|:.:..|.:.|:|.||||||.|.|::|||..|.::|:.||...:|...|.:...:...
Zfish   488 A-AGTSILFGVLIEAIGIAWFYGVDRFSDDIEEMIGQRPGLYWRLCWKFVSPCFLLFMVVVSFAT 551

  Fly   557 WTPVKYLDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVRIDED 614
            :.|.||..|.:|.||...||..::|||:.:|||.|:.:...||...:|:...:..:.|
Zfish   552 FNPPKYGSYYFPTWATMVGWCLSISSMIMVPLYAFYKFCSLPGSFCDKLAYAITPETD 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	248/554 (45%)
slc6a3	NP_571830.1	SLC6sbd_DAT1	76..623	CDD:212083	249/559 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820