DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and Slc6a1

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_077347.1	Gene:	Slc6a1 / 79212	RGDID:	620533	Length:	599	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	338/621 - (54%)
Similarity:	447/621 - (71%)	Gaps:	46/621 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MYTNSASDGDGGGDVCKHESIEMSKELGHTTSLQSSSPTTTDTSNKQQLVKIEQ----LPDRGSW 61
            |.|:::...||          ::|.|:       |.:|..:| ..|..:||:::    ||||.:|
  Rat     1 MATDNSKVADG----------QISTEV-------SEAPVASD-KPKTLVVKVQKKAGDLPDRDTW 47

  Fly    62 SSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGG 126
            ..:.||::|.||.||||||||||||||.|||||||::||.:||..||:|:|.:|.:|||..:|||
  Rat    48 KGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGG 112

  Fly   127 LGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQY 191
            |||:|:||:|||:|.||||:|.|:|:|||||::||::|.:.|....:||:.|:|.|||..|.|.|
  Rat   113 LGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNY 177

  Fly   192 ERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQISHGIEEIGNIRWELAGTL 256
                                  |.:|.|:  :|..|.|||||...|::.|:::.|.|||.||.||
  Rat   178 ----------------------SLVNTTN--MTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITL 218

  Fly   257 LLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSE 321
            .:.|:|.||||||||.||||||||:|.:||::|.||..||:|||||.|||.|||.|||.||::||
  Rat   219 AIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSE 283

  Fly   322 VWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHE 386
            ||:||.||||||||||||:|:||||||.|.||||:|::|||.:||.|||||||||||::|||||.
  Rat   284 VWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHV 348

  Fly   387 QQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWP 451
            .:|.:|||||||||||||.||.||.|||.||:|:.|||.|||::|:||||||:||||||::||:|
  Rat   349 TKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYP 413

  Fly   452 QLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVD 516
            :|||.|:|:|||.||.:|||:||:.|||||:|:|::.|.|:.||..||:|:|||||||||.|||:
  Rat   414 RLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVN 478

  Fly   517 RFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALS 581
            ||||.|::|:|..|.:|||.||...||.|..|||.|:.||.||:....|.:|.|....||..|||
  Rat   479 RFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALS 543

  Fly   582 SMLYIPLYMFWLWKRTPGELSEKIRALVRIDEDVTR 617
            ||:.||.||.:::....|.|.::::.:::..||:.|
  Rat   544 SMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVR 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	320/552 (58%)
Slc6a1	NP_077347.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		8/38 (21%)
		SLC6sbd_GAT1	2..599	CDD:212075	337/620 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..599		1/3 (33%)
		PDZ-binding	597..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	696	1.000	Domainoid score	I119
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2290
Inparanoid	1	1.050	720	1.000	Inparanoid score	I603
OMA	1	1.010	-	-		QHG49243
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	1	1.000	-	-		oto97598
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3352
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840