DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and zgc:158427

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_017207457.1	Gene:	zgc:158427 / 790932	ZFINID:	ZDB-GENE-061215-110	Length:	579	Species:	Danio rerio

Alignment Length:	560	Identity:	257/560 - (45%)
Similarity:	375/560 - (66%)	Gaps:	20/560 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 EQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELA 117
            |::.:||.|..|.:|:|:|.|..:|||||||||||||:||||.|::||::.:...|:|:|.:|.|
Zfish     6 EKIEERGFWGKKTEFLLAVAGNVVGLGNVWRFPYLCYRNGGGVFLIPYLVFVVTCGVPLFLLETA 70

  Fly   118 LGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNW 181
            :||....||:..: ::.|:.:|||||..:...:..:|:.:|||||:||...|..:.:||.:|:|.
Zfish    71 MGQFTHEGGITCWHRLCPLAQGIGYAGQLTVLYSCMYFTIILAWALFYLISSFSSQLPWASCDNI 135

  Fly   182 WNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQISHGIEEIG 246
            |||.|||      ||...:...|.|||.:     :|.||     ...||||||.|.:|.|||:||
Zfish   136 WNTDNCV------NLAAGNLTFNRTTQML-----INSTS-----AATEFWERRVLSLSGGIEDIG 184

  Fly   247 NIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYII 311
            .|.||:...|:.:||:||||||||||.|||||||||.||||:|.:||:||:||||||:||.||:.
Zfish   185 KINWEILLCLIAMWIICYFCIWKGVKSTGKVVYFTATFPYVMLIVLLIRGLTLPGALQGIVFYLY 249

  Fly   312 PNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVI 376
            |..::|.:.:||::|.|||||||.:..|.|::|||||::.||.|:|...:|.:||.||..|||.:
Zfish   250 PEPARLADPQVWMEAGTQIFFSYSVIGGVLISLGSYNQYNNNCYRDCFWLCLLNSGTSFVAGFAV 314

  Fly   377 FSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEG 441
            |||:|||||.|..|:.:||.|||||||:.||.||..:|...:|:..||.|::|:|||:||.::|.
Zfish   315 FSVLGFMAHVQGVPIEEVAESGPGLAFIAYPQAVAMMPFPQLWAVCFFIMIILLGLDTQFVSVEC 379

  Fly   442 FITAIIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFF 504
            .||:::|.:|::||:  |:|:.:.::|...:...|..:|:||||:||:.|:||.:|.|||:|..|
Zfish   380 VITSVMDLFPEVLRRAGRRELLVLLLCLTCFFGQLIMVTEGGMYVFQLFDNYACNGACLLFLSVF 444

  Fly   505 ECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YSYP 568
            |.::|.|.:|.::.:|.|:||....|..|:..||...||.:.|..|.:::|::||:.:.. |.||
Zfish   445 ESLAIGWIFGAEKMFDIIEDMTESRPNYWFMLCWKYLTPLVSLTSFVYSMVRYTPLTFNRWYIYP 509

  Fly   569 WWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRAL 608
            .||:..||..||||:|.:|.:.........|.|.::.|.|
Zfish   510 DWAYVLGWLLALSSILLVPAWALGQMCAGKGSLKQRWRHL 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	256/555 (46%)
zgc:158427	XP_017207457.1	SLC6sbd-TauT-like	11..552	CDD:271387	256/555 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820