Protein Alignment Gat and Slc6a19

DIOPT Version :9

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_083154.1
• Gene: Slc6a19 / 74338
• MGIID: 1921588
• Length: 634
• Species: Mus musculus
• Alignment Length: 637
• Identity: 213/637 - (33%)
• Similarity: 317/637 - (49%)
• Gaps: 113/637 - (17%)

  Fly    48 QLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMF 112
            ::::.|:...|..|.:|..::|:.||..:||||||||||||..:|||||::|::|.|...|||:.
Mouse    22 EVIEKEEAGSRPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLL 86

  Fly   113 FMELALGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWR 176
            ::|.|:||.|..|.:||: .|.|..||||.|:..:|..:.:||..|:||.::|||.|.:..:||.
Mouse    87 YLEFAIGQRLRKGSMGVWSSIHPALKGIGIASMFVSFMVGLYYNTIIAWVMWYFFNSFQEPLPWS 151

  Fly   177 TCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQISHG 241
            .|....|....|.:                    |:.|:          .|..||.|..|.||..
Mouse   152 ECPLNQNQTGYVEE--------------------CAKSS----------SVDYFWYRETLNISTS 186

  Fly   242 IEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGI 306
            |.:.|:|:|.:...|...|.:.|.||.:|::.|||.||.|:..|||:|||.|:||:||.||..||
Mouse   187 ISDSGSIQWWILLCLTCAWSVLYVCIIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGI 251

  Fly   307 KFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMF 371
            .|...||.::|:|...|:||..|:|:|:.|..|.|::..|||...||...|::||..:|..||::
Mouse   252 VFLFTPNITELSNPNTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEMDSVIVSVINGFTSVY 316

  Fly   372 AGFVIFSVIGFMAHEQ----------------QRPVADVAA------------------------ 396
            |..|::|:|||.|.|:                ..|..:|.:
Mouse   317 AATVVYSIIGFRATERFDDCVNTNILTLINGFDLPEGNVTSENFEAYQQWCNATNPQAYAQLKFQ 381

  Fly   397 ------------SGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIID- 448
                        .|.||||:|:..|:.::|.||:||.|||.||..:||.|.|..|||.:..:.|
Mouse   382 TCDINSFLSEGVEGTGLAFIVFTEAITKMPVSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDL 446

  Fly   449 -----EWPQLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVS 508
                 :||      ||:...::|..:||:........|.|...:|||:|.| ..||.:.|.|..:
Mouse   447 NITPKKWP------KELLTGLICLGTYLIAFIFTLNSGQYWLSLLDSFAGS-IPLLIIAFCEMFA 504

  Fly   509 ISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVF-FFNIVQ---------WTPVKYL 563
            :.:.||||||...|:.|||:.|.::|:..|.|.:|.|.|.:| ||.:::         |.| .|.
Mouse   505 VVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLIMLVIFLFFFVIEVNKTLMYSIWDP-NYE 568

  Fly   564 DY------SYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALV 609
            ::      .||.|.:|.....|....|.||.:..:.:.|...:.|:....||
Mouse   569 EFPKSQKIPYPNWVYAVVVTVAGVPCLSIPCFAIYKFIRNCCQKSDDHHGLV 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	212/627 (34%)
Slc6a19	NP_083154.1	SLC5-6-like_sbd	32..612	CDD:294310	209/617 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810