Protein Alignment Gat and slc6a4a

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001035061.1
• Gene: slc6a4a / 664719
• ZFINID: ZDB-GENE-060314-1
• Length: 646
• Species: Danio rerio
• Alignment Length: 608
• Identity: 253/608 - (41%)
• Similarity: 379/608 - (62%)
• Gaps: 39/608 - (6%)

  Fly     9 GDGGGDVC---KHESIEMSKELGHTTSLQSSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFILS 70
            |.|.|.|.   :..|.:..||...|.:.:.::|.|..|...|| ..::  |.|.:||.||||:||
Zfish    42 GSGPGQVSNGYRSTSPQSPKEGAGTGTDRVNTPGTFRTLVVQQ-TSLD--PPRETWSKKMDFLLS 103

  Fly    71 VVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFK-IAP 134
            |:|.|:.|||||||||:||:||||||:|||::.....|:|:|:|||||||....|.:.::| :.|
Zfish   104 VIGYAVDLGNVWRFPYICYQNGGGAFLLPYLLMAVFGGVPLFYMELALGQFHRSGCISIWKHVCP 168

  Fly   135 IFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCW 199
            ||||||:|..:::.::..||..|:|||::|...|.||.:||.||||.|||.|| :.|...:|:
Zfish   169 IFKGIGFAICIIALYIAFYYNTIMAWALYYLLSSFRATLPWTTCNNRWNTPNC-THYLSTDLN-- 230

  Fly   200 DKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQI--SHGIEEIGNIRWELAGTLLLVWIL 262
               ::.|...:              .|.:||:.|:.||:  |.|:.::|.:.|:||..||.::.:
Zfish   231 ---VSWTNNSI--------------SPAEEFYVRQVLQVHLSPGLHQLGWVSWQLALCLLFIFTV 278

  Fly   263 CYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAV 327
            .||.||||||.:||||:.||.|||::|.|||:||.|||||..|:.||:.|::.||..:.||:||.
Zfish   279 VYFSIWKGVKTSGKVVWVTATFPYLVLLILLIRGATLPGAWRGVVFYLKPDWKKLLTTTVWLDAA 343

  Fly   328 TQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVA 392
            .|||||.|.|.|.|:|..|||.|.||.||||||..:||..||..:|||||:|:|:||..:|:.|.
Zfish   344 AQIFFSLGPGFGVLLAFASYNPFHNNCYKDALITSSVNCLTSFLSGFVIFTVLGYMAEMRQQGVE 408

  Fly   393 DVAA-SGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLRK 456
            .||. :||.|.|::|..|:..:|.:..::.:||.|::::||||.|..:||.|||::||:|.||.:
Zfish   409 TVAKDAGPSLLFIIYAEAIANMPAATFFAIIFFLMIIMLGLDSTFAGLEGVITAMLDEFPHLLAR 473

  Fly   457 RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDG 521
            |:|.|:..:..:.||..|:.:|.||.::.::.:.|| :|..::.::|.|.:::||.||..||.:.
Zfish   474 RREWFVLGLVCVCYLGALSTLTYGGAFVVKLFEEYA-TGPAVITVVFLEVIAVSWFYGTTRFCND 537

  Fly   522 IKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQW----TPVKYLDYSYPWWAHAFGWFTALSS 582
            ::.|:|:.|.::|:.||.    |||.....|.||.:    ..||..||.||:|....|:...:||
Zfish   538 VQLMLGFAPGLFWRVCWI----AICPCFLLFIIVSFLAFPPEVKLFDYLYPFWTTVLGYCIGVSS 598

  Fly   583 MLYIPLYMFWLWKRTPGELSEKI 605
            .:.:|.||.:....|.|...:::
Zfish   599 FICVPSYMVYHLVTTKGTFQQRL 621

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	239/556 (43%)
slc6a4a	NP_001035061.1	SLC5-6-like_sbd	91..628	CDD:444915	239/556 (43%)