Protein Alignment Gat and SLC6A13

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_057699.2
• Gene: SLC6A13 / 6540
• HGNCID: 11046
• Length: 602
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 304/597 - (50%)
• Similarity: 412/597 - (69%)
• Gaps: 27/597 - (4%)

  Fly    23 MSKELGHTTSLQSSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYL 87
            |...:..|||...:.|.......|::...:|    ||.|::||:|:|||.|..||||||||||||
Human     1 MDSRVSGTTSNGETKPVYPVMEKKEEDGTLE----RGHWNNKMEFVLSVAGEIIGLGNVWRFPYL 61

  Fly    88 CYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMN 151
            |||||||||.:||::.||..|||:|.:|.||||..:.||:..: ||.|||:|||||:.::...:|
Human    62 CYKNGGGAFFIPYLVFLFTCGIPVFLLETALGQYTSQGGVTAWRKICPIFEGIGYASQMIVILLN 126

  Fly   152 VYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSAL 216
            ||||::||||:||.|.|...|:||..|.:.|||.:|: ::::.|                  .:|
Human   127 VYYIIVLAWALFYLFSSFTIDLPWGGCYHEWNTEHCM-EFQKTN------------------GSL 172

  Fly   217 NITSLELTDPVKEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFT 281
            |.||...|.||.||||||.|:||.||:.:|.:|||||..|||.|::||||||||||.||||||||
Human   173 NGTSENATSPVIEFWERRVLKISDGIQHLGALRWELALCLLLAWVICYFCIWKGVKSTGKVVYFT 237

  Fly   282 ALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGS 346
            |.|||::|.:||:||:|||||.:||:||:.||.::|.:.:||:||.||||||:.:.||.|.||||
Human   238 ATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNLTRLWDPQVWMDAGTQIFFSFAICLGCLTALGS 302

  Fly   347 YNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVL 411
            |||:.||.|:|.:.:|.:||.||..|||.|||::|||:.||..|:::||.|||||||:.||.||:
Human   303 YNKYHNNCYRDCIALCFLNSGTSFVAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVV 367

  Fly   412 QLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLRK--RKEIFIAIVCALSYLVGL 474
            .||.||:|:|.||||::|:||||||..:|..:||::|.:|.:.||  |:|:.|..|..:|:||||
Human   368 MLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPHVFRKKNRREVLILGVSVVSFLVGL 432

  Fly   475 TCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWC 539
            ..:|:||||:||:.|.||.||.|||::..||.:.::|.||..||||.|:|||||.|....|:||.
Human   433 IMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAKRFYDNIEDMIGYRPWPLIKYCWL 497

  Fly   540 VTTPAICLGVFFFNIVQWTPVKY-LDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSE 603
            ..|||:|...|.|:::::||:.| ..|:||||..|.||..|||||:.||.:..:......|...|
Human   498 FLTPAVCTATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMVCIPAWSLYRLGTLKGPFRE 562

  Fly   604 KIRALVRIDEDV 615
            :||.|:...||:
Human   563 RIRQLMCPAEDL 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	295/556 (53%)
SLC6A13	NP_057699.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		5/20 (25%)
		SLC6sbd_GAT2	32..575	CDD:271396	297/562 (53%)