Protein Alignment Gat and SLC6A12

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_003035.3
• Gene: SLC6A12 / 6539
• HGNCID: 11045
• Length: 614
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 301/573 - (52%)
• Similarity: 405/573 - (70%)
• Gaps: 24/573 - (4%)

  Fly    53 EQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELA 117
            :|:.|||.|::||:|:|||.|..|||||||||||||||||||||.:||.|..|:.|||:||:|:|
Human    31 DQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVA 95

  Fly   118 LGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNW 181
            |||..:.|.:..: ||.|:|:|||.|:.|:..::|||||:|||||:||.|.|..:::||.||||:
Human    96 LGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNF 160

  Fly   182 WNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLE-LTDPVKEFWERRALQISHGIEEI 245
            |||.           ||.| .:|.:       .|..:|..| .|.||.||||||.|.|:.||.::
Human   161 WNTE-----------HCTD-FLNHS-------GAGTVTPFENFTSPVMEFWERRVLGITSGIHDL 206

  Fly   246 GNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYI 310
            |::|||||..|||.|::||||||||||.|||||||||.|||::|.|||:||:|||||.:||.:|:
Human   207 GSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYL 271

  Fly   311 IPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFV 375
            .|:..:|.:.:||:||.||||||:.:..|.|.|||||||:.||.|||.:.:|.:||:||..||||
Human   272 KPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFV 336

  Fly   376 IFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTME 440
            :||::|||:.||..|:::||.|||||||:.:|.||..:|.|.:||||||.||:.:||||||..:|
Human   337 VFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVE 401

  Fly   441 GFITAIIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIF 503
            ..:||.||.:|:.|||  |:|:.|..:..:.||:||..:|:|||||||:.|.||.||.|||:|..
Human   402 CLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSL 466

  Fly   504 FECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YSY 567
            ||.|.|||.||.|||||.|:|||||.|....|..|...||.:||..|.|::.::||:||.: |.|
Human   467 FEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVY 531

  Fly   568 PWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVRIDEDVTRLRE 620
            |.|.::.|||.|||||:.:||::.....:|.|...:::|.|:..|..:.:.::
Human   532 PPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQ 584

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	298/557 (54%)
SLC6A12	NP_003035.3	SLC6sbd_BGT1	35..575	CDD:212080	299/558 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..614		1/9 (11%)