DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and SLC6A11

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_055044.1	Gene:	SLC6A11 / 6538	HGNCID:	11044	Length:	632	Species:	Homo sapiens

Alignment Length:	571	Identity:	304/571 - (53%)
Similarity:	405/571 - (70%)	Gaps:	24/571 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 DRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQM 121
            :||.|::|::|:|||.|..|||||||||||||||||||||::||::.....|||:||:|.||||.
Human    49 ERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQF 113

  Fly   122 LTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTV 185
            .:.||:..: |:.|:|:|||||..|:...:|||||:|||||:||.......::||.||.:.|||.
Human   114 TSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTE 178

  Fly   186 NCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQISHGIEEIGNIRW 250
            ||| ::::.|:           .....||..|.||     ||.||||.|.|.||.|||.|||:||
Human   179 NCV-EFQKLNV-----------SNYSHVSLQNATS-----PVMEFWEHRVLAISDGIEHIGNLRW 226

  Fly   251 ELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFS 315
            |||..||..|.:||||||||.|.||||||.||.|||::|.|||:||:|||||.||||||:.|:.|
Human   227 ELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLS 291

  Fly   316 KLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVI 380
            :|::.:||:||.|||||||.:.||.|.||||||.:.||.|:|.:::|.:||.||..|||.||||:
Human   292 RLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVL 356

  Fly   381 GFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITA 445
            ||||:||..|:|:||.|||||||:.||.||..:|.||:|:.|||.||:.:||||||..:|..:||
Human   357 GFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTA 421

  Fly   446 IIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVS 508
            ::|.:|::.|:  |:|:.|..:..:||.:||..:|:|||||||:.||||.||.|||::..|||:.
Human   422 VVDMYPKVFRRGYRRELLILALSVISYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECIC 486

  Fly   509 ISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YSYPWWAH 572
            |.|.||.:||||.|:|||||.|....|:||.:.||.||.|:|.|.::::.|:||.: |:||.|.:
Human   487 IGWVYGSNRFYDNIEDMIGYRPPSLIKWCWMIMTPGICAGIFIFFLIKYKPLKYNNIYTYPAWGY 551

  Fly   573 AFGWFTALSSMLYIPLYM-FWLWKRTPGELSEKIRALVRIDEDVTRLREKM 622
            ..||..||||||.|||:: ..:|| |.|.|.||::.|.....|: ::|.|:
Human   552 GIGWLMALSSMLCIPLWICITVWK-TEGTLPEKLQKLTTPSTDL-KMRGKL 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	301/557 (54%)
SLC6A11	NP_055044.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
SLC6A11	NP_055044.1	SLC6sbd_GAT3	49..590	CDD:212077	301/558 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820