Protein Alignment Gat and SLC6A9

DIOPT Version :9

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_964012.2
• Gene: SLC6A9 / 6536
• HGNCID: 11056
• Length: 706
• Species: Homo sapiens
• Alignment Length: 593
• Identity: 253/593 - (42%)
• Similarity: 381/593 - (64%)
• Gaps: 23/593 - (3%)

  Fly    29 HTTSLQSSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGG 93
            |:.::..:....::.:.:.|.:|      ||:|.::::|:|:.||.|:|||||||||||||:|||
Human    77 HSLAMAQNGAVPSEATKRDQNLK------RGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGG 135

  Fly    94 GAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVIL 158
            |||:.||.|.|...|||:|||||:.||..:.|.|||::|:|:|||:||...|:|.::.:||.|::
Human   136 GAFMFPYFIMLIFCGIPLFFMELSFGQFASQGCLGVWRISPMFKGVGYGMMVVSTYIGIYYNVVI 200

  Fly   159 AWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKV--CSVSALNITSL 221
            ..|.:|||.||...:||..|||.|||.:|....:..||      .||:....  .::|.|...||
Human   201 CIAFYYFFSSMTHVLPWAYCNNPWNTHDCAGVLDASNL------TNGSRPAALPSNLSHLLNHSL 259

  Fly   222 ELTDPVKEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPY 286
            :.|.|.:|:|....|::|..|...|.:|..|.|.|.:.|::.:.|:.:|||.:||||||||.|||
Human   260 QRTSPSEEYWRLYVLKLSDDIGNFGEVRLPLLGCLGVSWLVVFLCLIRGVKSSGKVVYFTATFPY 324

  Fly   287 VLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFT 351
            |:||||.|||:||.||.:||.:|:.|.:.|:..::||.||.:|||:|.|...|.|:.:.|||||.
Human   325 VVLTILFVRGVTLEGAFDGIMYYLTPQWDKILEAKVWGDAASQIFYSLGCAWGGLITMASYNKFH 389

  Fly   352 NNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGS 416
            ||.|:|::|:...|.:||::|||||||::||||:.....|:.||..||||||:.||.|:..||.|
Human   390 NNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVADHGPGLAFVAYPEALTLLPIS 454

  Fly   417 PMWSCLFFFMLLLIGLDSQFCTMEGFITAIID----EWPQLLRKRKEIFIAIVCALSYLVGLTCI 477
            |:||.||||||:|:||.:|||.:|..:|||:|    ||  :|:|:..:.:.:..| .:|:|:...
Human   455 PLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEW--ILQKKTYVTLGVAVA-GFLLGIPLT 516

  Fly   478 TQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTT 542
            :|.|:|...::|:||.| |.|:.:....||:|.:.||...::..|:.|:|:.|.::::.||...:
Human   517 SQAGIYWLLLMDNYAAS-FSLVVISCIMCVAIMYIYGHRNYFQDIQMMLGFPPPLFFQICWRFVS 580

  Fly   543 PAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGE-LSEKIR 606
            |||...:..|.::|:.|:.|..|.||.||.|.|:..||||:|.||||..:...||.|: |.::::
Human   581 PAIIFFILVFTVIQYQPITYNHYQYPGWAVAIGFLMALSSVLCIPLYAMFRLCRTDGDTLLQRLK 645

  Fly   607 ALVRIDED 614
            ...:...|
Human   646 NATKPSRD 653

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	249/559 (45%)
SLC6A9	NP_964012.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		SLC6sbd_GlyT1	84..667	CDD:212067	252/586 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820