DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and SLC6A8

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_005620.1	Gene:	SLC6A8 / 6535	HGNCID:	11055	Length:	635	Species:	Homo sapiens

Alignment Length:	562	Identity:	288/562 - (51%)
Similarity:	392/562 - (69%)	Gaps:	20/562 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALG 119
            :|.|.:|:.:||||:|.||.|:||||||||||||||||||.|::||::...:.|||:||:|::||
Human    49 VPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLG 113

  Fly   120 QMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNT 184
            |.:..|.:.|:.|.|:|||:|||:.|:..:.|.|||::|||..:|...|....:||.||.:.|||
Human   114 QFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNT 178

  Fly   185 VNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTD---PVKEFWERRALQISHGIEEIG 246
            .:||..:..::  |            .:.|..|:|..:|.|   ||.||||.:.|::|.|:|..|
Human   179 PDCVEIFRHED--C------------ANASLANLTCDQLADRRSPVIEFWENKVLRLSGGLEVPG 229

  Fly   247 NIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYII 311
            .:.||:...||..|:|.|||:|||||.|||:|||||.||||:|.:|||||:.|||||:||.:|:.
Human   230 ALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLK 294

  Fly   312 PNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVI 376
            |::|||.:.:|||||.|||||||.:|||.|.||||||:|.||.||||:|:..:||.||.|||||:
Human   295 PDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVV 359

  Fly   377 FSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEG 441
            ||::||||.||...::.||.|||||||:.||.||..:|.:|:|:.||||||||:||||||..:||
Human   360 FSILGFMAAEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEG 424

  Fly   442 FITAIIDEWP--QLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFF 504
            |||.::|..|  ...|.::||.:|:.|||.:::.|:.:|.||||:||:.|.|:.||..|||..|:
Human   425 FITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFW 489

  Fly   505 ECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YSYP 568
            |||.::|.||.|||.|.|..||||.|..|.|:||...||.:|:|:|.||:|.:.|:.|.: |.||
Human   490 ECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNVVYYEPLVYNNTYVYP 554

  Fly   569 WWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVR 610
            ||..|.||..||||||.:||::.....|..|.::|:.:.|.:
Human   555 WWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQ 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	287/559 (51%)
SLC6A8	NP_005620.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..28
SLC6A8	NP_005620.1	SLC6sbd_CT1	52..621	CDD:271397	287/559 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820