DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and SLC6A7

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_016865256.1	Gene:	SLC6A7 / 6534	HGNCID:	11054	Length:	754	Species:	Homo sapiens

Alignment Length:	618	Identity:	268/618 - (43%)
Similarity:	370/618 - (59%)	Gaps:	36/618 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GHTTS----LQSS---SPTTTD---TSNKQQLV--KIEQLPDRGSWSSKMDFILSVVGLAIGLGN 80
            ||..|    ||.:   .|.|.|   |.:.|..|  .::....||:|:.|:||:||.:|..:||||
Human    76 GHPLSKMKKLQGAHLRKPVTPDLLMTPSDQGDVDLDVDFAAHRGNWTGKLDFLLSCIGYCVGLGN 140

  Fly    81 VWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFKIAPIFKGIGYAAAV 145
            ||||||..|.||||||::||.:.|.:.|||:||:||:|||..::|.|.|:||:|:|||.|.|..:
Human   141 VWRFPYRAYTNGGGAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVWKISPLFKGAGAAMLL 205

  Fly   146 MSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERK--------NLHC---- 198
            :...:.:||.:|:|:.:||.|.|:.:|:||..|.|||||..|:.....|        ||.|
Human   206 IVGLVAIYYNMIIAYVLFYLFASLTSDLPWEHCGNWWNTELCLEHRVSKDGNGALPLNLTCTVSP 270

  Fly   199 ----WDKI-----INGTTQKVCSVSALNITSLELTDPVKEFWERRALQI--SHGIEEIGNIRWEL 252
                |.:.     ..|...:|.|.|...:..|......:|...|..|.|  |.||...|.|||.|
Human   271 SEEYWSQTHTEAEEEGRRGRVVSNSYPQVIFLPQPPKAEEGVSRYVLHIQGSQGIGSPGEIRWNL 335

  Fly   253 AGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKL 317
            ...|||.|::.:.||.||||.:||||||||.|||::|.:|||||:|||||.:||:||:.|.|..|
Human   336 CLCLLLAWVIVFLCILKGVKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHL 400

  Fly   318 TNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGF 382
            .:|:|||:|..|||:|.|:|.|.|:...|||.|..|:|:|..||...|:.||:.|||.||||:|:
Human   401 LSSKVWIEAALQIFYSLGVGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGY 465

  Fly   383 MAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAII 447
            |:.|...||..||.:||||||:|||.|:..||.||.||.|||||||.:||||||..:|..:||:.
Human   466 MSQELGVPVDQVAKAGPGLAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVT 530

  Fly   448 DEWPQLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWC 512
            ||:|..||.:|.:|..::|...||:||...|.||||...:||.|:.| |.|:.::...|::::..
Human   531 DEFPYYLRPKKAVFSGLICVAMYLMGLILTTDGGMYWLVLLDDYSAS-FGLMVVVITTCLAVTRV 594

  Fly   513 YGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWF 577
            ||:.||...|..|:|:.|.::::.||...:||..|.:..::||::.|.:|..|.:|.||...|..
Human   595 YGIQRFCRDIHMMLGFKPGLYFRACWLFLSPATLLALMVYSIVKYQPSEYGSYRFPPWAELLGIL 659

  Fly   578 TALSSMLYIPLYMFWLWKRTPGELSEKIRALVR 610
            ..|.|.|.||..|.....|..|.|.|:::...|
Human   660 MGLLSCLMIPAGMLVAVLREEGSLWERLQQASR 692

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	257/576 (45%)
SLC6A7	XP_016865256.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820