Protein Alignment Gat and SLC6A6

DIOPT Version :9

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001127839.2
• Gene: SLC6A6 / 6533
• HGNCID: 11052
• Length: 721
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 313/633 - (49%)
• Similarity: 416/633 - (65%)
• Gaps: 54/633 - (8%)

  Fly    12 GGDVCKHESIEMSKELGH------TTSLQSSSPTTTDTSNKQQLVKIEQL--------------- 55
            ||  .:|...|..:...|      ||:|..|| .|.:.:.|::|..::..
Human    68 GG--TRHSRAERGRRRSHPRSRTRTTALLRSS-QTKEMATKEKLQCLKDFHKDILKPSPGKSPGT 129

  Fly    56 ----------PDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIP 110
                      |.|..||||:||:|||.|..:||||||||||||||||||||::||.|.||.:|:|
Human   130 RPEDEAEGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLP 194

  Fly   111 MFFMELALGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVP 174
            :||:|:.:||..:.||:..: ||.|:|.|||||:.|:...:|||||||||||.:|.|.|.:.::|
Human   195 VFFLEIIIGQYTSEGGITCWEKICPLFSGIGYASVVIVSLLNVYYIVILAWATYYLFQSFQKELP 259

  Fly   175 WRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQIS 239
            |..||:.|||.:|:....|||...|                :.|:|...|.||.|||||..|.:|
Human   260 WAHCNHSWNTPHCMEDTMRKNKSVW----------------ITISSTNFTSPVIEFWERNVLSLS 308

  Fly   240 HGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALE 304
            .||:..|:::|:||..|||||::|:|||||||:.|||||||||.||:.:|.:|||||:|||||..
Human   309 PGIDHPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGA 373

  Fly   305 GIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTS 369
            |||||:.|:.::|.:.:|||||.|||||||.:.||.:.:||||||:..|.|:|.:::..:||.||
Human   374 GIKFYLYPDITRLEDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTS 438

  Fly   370 MFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDS 434
            ..:||.|||::||||.||...:||||.|||||||:.||.||..:|....||.|||.||||:||||
Human   439 FVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDS 503

  Fly   435 QFCTMEGFITAIIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFC 497
            ||..:||.||:::|.:|..|||  |:|||||.||::|||:|||.:|:||||:||:.|.||.||.|
Human   504 QFVEVEGQITSLVDLYPSFLRKGYRREIFIAFVCSISYLLGLTMVTEGGMYVFQLFDYYAASGVC 568

  Fly   498 LLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKY 562
            |||:.||||..|:|.||.|..||||:|||||.|..|.|:.|.|.||.:|:|.|.|::|::.|:.|
Human   569 LLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPVLCVGCFIFSLVKYVPLTY 633

  Fly   563 -LDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALV 609
             ..|.||.||...||..||||||.:||.:.....:|.|....:::.|:
Human   634 NKTYVYPNWAIGLGWSLALSSMLCVPLVIVIRLCQTEGPFLVRVKYLL 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	299/556 (54%)
SLC6A6	NP_001127839.2	SLC6sbd_TauT	142..683	CDD:271398	299/556 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820