Protein Alignment Gat and SLC6A4

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001036.1
• Gene: SLC6A4 / 6532
• HGNCID: 11050
• Length: 630
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 251/605 - (41%)
• Similarity: 361/605 - (59%)
• Gaps: 48/605 - (7%)

  Fly     5 SASDGDGGGDVCKHESIEMSKELGHTTSLQSSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFIL 69
            ||....|.||..:|                 |.|.||.|     ||......:|.:|..|:||:|
Human    48 SAVPSPGAGDDTRH-----------------SIPATTTT-----LVAELHQGERETWGKKVDFLL 90

  Fly    70 SVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVF-KIA 133
            ||:|.|:.|||||||||:||:||||||:|||.|.....|||:|:|||||||....|.:.:: ||.
Human    91 SVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKIC 155

  Fly   134 PIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHC 198
            |||||||||..:::.::..||..|:|||::|...|....:||.:|.|.|||.||.:.:...|: .
Human   156 PIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNI-T 219

  Fly   199 WDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQI--SHGIEEIGNIRWELAGTLLLVWI 261
            |                    :|..|.|.:||:.|..|||  |.|::::|.|.|:||..::|::.
Human   220 W--------------------TLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFT 264

  Fly   262 LCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDA 326
            :.||.||||||.:||||:.||.|||::|::|||||.|||||..|:.||:.||:.||..:.|||||
Human   265 VIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDA 329

  Fly   327 VTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPV 391
            ..|||||.|.|.|.|:|..|||||.||.|:|||:...||..||..:|||||:|:|:||..:...|
Human   330 AAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDV 394

  Fly   392 ADVAA-SGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLR 455
            ::||. :||.|.|:.|..|:..:|.|..::.:||.||:.:||||.|..:||.|||::||:|.:..
Human   395 SEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWA 459

  Fly   456 KRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYD 520
            ||:|.|:..|....:...|..:|.||.|:.::|:.|| :|..:|.:...|.|::||.||:.:|..
Human   460 KRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYA-TGPAVLTVALIEAVAVSWFYGITQFCR 523

  Fly   521 GIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALSSMLY 585
            .:|:|:|:.|..:|:.||...:|...|.:....::....::...|:||:|:...|:....||.:.
Human   524 DVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFIC 588

  Fly   586 IPLYMFWLWKRTPGELSEKI 605
            ||.|:.:....|||...|:|
Human   589 IPTYIAYRLIITPGTFKERI 608

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	238/552 (43%)
SLC6A4	NP_001036.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..59		5/10 (50%)
		5HT_transport_N	24..64	CDD:397524	7/32 (22%)
		SLC6sbd_SERT	79..615	CDD:271399	238/552 (43%)
		Interaction with RAB4A	616..624