Protein Alignment Gat and SLC6A3

DIOPT Version :9

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001035.1
• Gene: SLC6A3 / 6531
• HGNCID: 11049
• Length: 620
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 257/578 - (44%)
• Similarity: 377/578 - (65%)
• Gaps: 23/578 - (3%)

  Fly    39 TTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIIT 103
            ::|.|:.:|..|:.:   ||.:|..|:||:|||:|.|:.|.|||||||||||||||||::||::.
Human    44 SSTLTNPRQSPVEAQ---DRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLF 105

  Fly   104 LFLAGIPMFFMELALGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMS 168
            :.:||:|:|:|||||||....|..||:||.||.||:|:...::|.::..:|.||:|||:.|.|.|
Human   106 MVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSS 170

  Fly   169 MRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWER 233
            ...::||..|||.||:.||      .:.|..|.  :|.:      |.||.|.  .|.|..|::||
Human   171 FTTELPWIHCNNSWNSPNC------SDAHPGDS--SGDS------SGLNDTF--GTTPAAEYFER 219

  Fly   234 RALQI--SHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRG 296
            ..|.:  ||||:::|..||:|...|:||.:|.||.:|||||.:||||:.||..|||:||.||:||
Human   220 GVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRG 284

  Fly   297 ITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIV 361
            :|||||::||:.|:..:|.:|..:.|||||.||:.||.|:|.|.|:|..||||||||.|:||::.
Human   285 VTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVT 349

  Fly   362 CTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFM 426
            .::||.||..:|||:||.:|:||.:...|:.|||..||||.|::||.|:..||.|..|:.:||.|
Human   350 TSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIM 414

  Fly   427 LLLIGLDSQFCTMEGFITAIIDEWPQLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSY 491
            ||.:|:||....||..||.:|||: |||.:.:|:|...:...::|:.|.|:|.||:|:|.:||.:
Human   415 LLTLGIDSAMGGMESVITGLIDEF-QLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHF 478

  Fly   492 AVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQ 556
            | :|..:|:.:..|.:.::|.|||.:|.|.|:.|.|..|:::|:.||.:.:|...|.|...:||.
Human   479 A-AGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVT 542

  Fly   557 WTPVKYLDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVRIDED 614
            :.|..|..|.:|.||:|.||..|.|||..:|:|..:.:...||...||:...:..::|
Human   543 FRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD 600

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	251/554 (45%)
SLC6A3	NP_001035.1	SLC6sbd_DAT1	60..614	CDD:212083	252/559 (45%)
		Interaction with TGFB1I1. /evidence=ECO:0000269|PubMed:12177201	561..590		10/28 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820