DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and SLC6A2

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001165975.1	Gene:	SLC6A2 / 6530	HGNCID:	11048	Length:	628	Species:	Homo sapiens

Alignment Length:	550	Identity:	246/550 - (44%)
Similarity:	359/550 - (65%)	Gaps:	19/550 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 RGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQML 122
            |.:|..|:||:|||||.|:.|.|||||||||||||||||::||.:.|.:||:|:|:|||||||..
Human    56 RETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN 120

  Fly   123 TIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNC 187
            ..|...|:||.|.|||:|||..:::.::..||.||:||:::|.|.|...::||..|.:.||:.||
Human   121 REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTWNSPNC 185

  Fly   188 VSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQI--SHGIEEIGNIRW 250
            ..          .|::||:...    :....:..:.| |..||:||..|.:  |.||.:||..:|
Human   186 TD----------PKLLNGSVLG----NHTKYSKYKFT-PAAEFYERGVLHLHESSGIHDIGLPQW 235

  Fly   251 ELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFS 315
            :|...|::|.|:.||.:|||||.:||||:.||..||.:|.:|||.|:|||||..||..|:..:|.
Human   236 QLLLCLMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY 300

  Fly   316 KLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVI 380
            :|..:.|||||.||||||.|.|.|.|:|..|||||.||.|:|||:..::|..||..:||.|||::
Human   301 RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFAIFSIL 365

  Fly   381 GFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITA 445
            |:||||.:..:.|||..|.||.|::||.|:..|.||..|:.:||.|||.:||||....||..||.
Human   366 GYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSSMGGMEAVITG 430

  Fly   446 IIDEWPQLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSIS 510
            :.|:: |:|::.:::|...|...::|:.|.|||:||:|:..:||::| :|..:|:.:..|.:.:|
Human   431 LADDF-QVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFA-AGTSILFAVLMEAIGVS 493

  Fly   511 WCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFG 575
            |.||||||.:.|:.|:|:.|.::|:.||...:||..|.|...:|:.:.|:.|.||.:|.||:..|
Human   494 WFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYIFPPWANWVG 558

  Fly   576 WFTALSSMLYIPLYMFWLWKRTPGELSEKI 605
            |..|||||:.:|:|:.:.:..|.|.|.|::
Human   559 WGIALSSMVLVPIYVIYKFLSTQGSLWERL 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	246/549 (45%)
SLC6A2	NP_001165975.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
SLC6A2	NP_001165975.1	SLC6sbd_NET	56..612	CDD:212081	246/549 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820