Protein Alignment Gat and SLC6A1

DIOPT Version :9

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001335179.1
• Gene: SLC6A1 / 6529
• HGNCID: 11042
• Length: 599
• Species: Homo sapiens
• Alignment Length: 621
• Identity: 342/621 - (55%)
• Similarity: 446/621 - (71%)
• Gaps: 46/621 - (7%)

  Fly     1 MYTNSASDGDGGGDVCKHESIEMSKELGHTTSLQSSSPTTTDTSNKQQLVKIEQ----LPDRGSW 61
            |.||.:...||          ::|.|:       |.:|...| ..|..:||:::    ||||.:|
Human     1 MATNGSKVADG----------QISTEV-------SEAPVAND-KPKTLVVKVQKKAADLPDRDTW 47

  Fly    62 SSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGG 126
            ..:.||::|.||.||||||||||||||.|||||||::||.:||..||:|:|.:|.:|||..:|||
Human    48 KGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGG 112

  Fly   127 LGVFKIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQY 191
            |||:|:||:|||:|.||||:|.|:|:|||||::||::|.:.|....:||:.|:|.|||..|.|.|
Human   113 LGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNY 177

  Fly   192 ERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWERRALQISHGIEEIGNIRWELAGTL 256
                                  |.:|.|:  :|..|.|||||...|::.|:::.|.|||.||.||
Human   178 ----------------------SMVNTTN--MTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITL 218

  Fly   257 LLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSE 321
            .:.|||.||||||||.||||||||:|.:||::|.||..||:|||||.|||.|||.|||.||::||
Human   219 AIAWILVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSE 283

  Fly   322 VWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHE 386
            ||:||.||||||||||||:|:||||||.|.||||:|::|||.:||.|||||||||||::|||||.
Human   284 VWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHV 348

  Fly   387 QQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWP 451
            .:|.:|||||||||||||.||.||.|||.||:|:.|||.|||::|:||||||:||||||::||:|
Human   349 TKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYP 413

  Fly   452 QLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVD 516
            :|||.|:|:|||.||.:|||:||:.|||||:|:|::.|.|:.||..||:|:|||||||||.|||:
Human   414 RLLRNRRELFIAAVCIISYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVN 478

  Fly   517 RFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALS 581
            ||||.|::|:|..|.:|||.||...||.|..|||.|:.||.||:...:|.:|.|....||..|||
Human   479 RFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFIFSAVQMTPLTMGNYVFPKWGQGVGWLMALS 543

  Fly   582 SMLYIPLYMFWLWKRTPGELSEKIRALVRIDEDVTR 617
            ||:.||.||.:::....|.|.::|:.:|:..||:.|
Human   544 SMVLIPGYMAYMFLTLKGSLKQRIQVMVQPSEDIVR 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	323/552 (59%)
SLC6A1	NP_001335179.1	SLC6sbd_GAT1	2..599	CDD:212075	341/620 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		1/3 (33%)
		PDZ-binding	597..599

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	698	1.000	Domainoid score	I128
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2290
Inparanoid	1	1.050	722	1.000	Inparanoid score	I630
Isobase	1	0.950	-	0	Normalized mean entropy	S2610
OMA	1	1.010	-	-		QHG49243
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	1	1.000	-	-		oto90487
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3258
SonicParanoid	1	1.000	-	-		X3352
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820