DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and slc6a8

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001314797.1	Gene:	slc6a8 / 567544	ZFINID:	ZDB-GENE-071024-2	Length:	652	Species:	Danio rerio

Alignment Length:	614	Identity:	301/614 - (49%)
Similarity:	415/614 - (67%)	Gaps:	26/614 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DVCKHESIEMSKELGHTTSLQSSSPTTTDTSNKQQL-----------VKIEQLPDRGSWSSKMDF 67
            |.|....:.:.::.||.....::.|:...|.|...:           .|.|..|:|.:|:.:|||
Zfish     9 DCCALNMVLVEEKKGHLIPNGNAHPSVNGTLNGGPMSAATGAISAVEKKREGYPERETWTRQMDF 73

  Fly    68 ILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFKI 132
            |:|.||.|:||||||||||||||||||.|::||::.:||.|||:||:|:||||.:..|.:.|:.|
Zfish    74 IMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLFIFLGGIPIFFLEIALGQFMKAGSINVWNI 138

  Fly   133 APIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLH 197
            ||:|||:|||:.|:..:.|.|||::|||..:||..|..|.:||.||:|.|||.||:..:.:.:..
Zfish   139 APLFKGLGYASMVIVFFCNTYYIMVLAWGFYYFIKSFNATLPWSTCDNPWNTENCIEIFRQGDCK 203

  Fly   198 CWDKIINGTTQKVCSVSALNITSLELTD---PVKEFWERRALQISHGIEEIGNIRWELAGTLLLV 259
                  |||   :.:.:..|:|..||.:   |:.||||.:.|.||.|::|.|.:.|||...||.|
Zfish   204 ------NGT---IGNSTFGNLTCEELANGRSPIIEFWENKVLNISDGLDEPGAVNWELMLCLLAV 259

  Fly   260 WILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWI 324
            |::.|||:|||||.|||:|||||.||||:|.||||||:|||||.:||.:|:.|::|||..::|||
Zfish   260 WVMVYFCVWKGVKSTGKIVYFTATFPYVVLIILLVRGVTLPGAYDGILYYVKPDWSKLGEAQVWI 324

  Fly   325 DAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQR 389
            ||.|||||||.:|||.|.||||||:|.|:.||||.::..:||.||.|||||:||::||||.||..
Zfish   325 DAGTQIFFSYAIGLGALTALGSYNRFNNDCYKDAFVLALINSGTSFFAGFVVFSILGFMASEQGV 389

  Fly   390 PVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWP--Q 452
            .::.||.|||||||:.||.||..:|.:|:|:.|||.||||:||||||..:|||:|.|:|.:|  .
Zfish   390 DISKVAESGPGLAFIAYPKAVSMMPVAPVWAALFFIMLLLLGLDSQFVGVEGFVTGILDLFPGKY 454

  Fly   453 LLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDR 517
            .:|.::||.:||.|.|.:::.|:.:||||||:||:.|.|:.||..|||..|:|||.::|.||.||
Zfish   455 YMRYQREIAVAICCLLCFIIDLSMVTQGGMYVFQLFDYYSASGMTLLWQAFWECVVVAWVYGADR 519

  Fly   518 FYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YSYPWWAHAFGWFTALS 581
            |.|.|..||||.|..|.|:||.:.||.:|:|:|.|:::.:.|:.|.: |.||||....||..|||
Zfish   520 FMDDIARMIGYRPFPWMKWCWSIITPCVCMGIFLFHLLNYKPLTYNNVYVYPWWGEVIGWCLALS 584

  Fly   582 SMLYIPLYMFWLWKRTPGELSEKIRALVR 610
            |||.||:.:.:......|...|:...|.:
Zfish   585 SMLCIPVSLVYKLSGAKGTFKERWENLTK 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	291/559 (52%)
slc6a8	NP_001314797.1	SLC6sbd_CT1	64..652	CDD:271397	291/559 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820