DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and slc6a22.2

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	XP_005166102.1	Gene:	slc6a22.2 / 561024	ZFINID:	ZDB-GENE-030616-628	Length:	608	Species:	Danio rerio

Alignment Length:	589	Identity:	288/589 - (48%)
Similarity:	392/589 - (66%)	Gaps:	31/589 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SSSPTTTDTSNKQQLVKIE-QLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFIL 98
            ||.|..........|||.. :.|.|..|::|::|:|:|.|..|||||||||||||||||||||.:
Zfish     4 SSRPAVKLNLLNGALVKARPKPPAREQWANKLEFLLAVAGHIIGLGNVWRFPYLCYKNGGGAFFV 68

  Fly    99 PYIITLFLAGIPMFFMELALGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAV 162
            ||::.||..|||:||:|.:|||..:.||:..: ||.|:|:|:|:.:.|:..:..||||:|||||.
Zfish    69 PYVLFLFTCGIPLFFLETSLGQFTSQGGITCWRKICPLFEGLGFGSQVVVLYTGVYYIIILAWAF 133

  Fly   163 FYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSL---ELT 224
            .|.|.|..:::||.:|||:|||.:|:                       ..|..|||..   :.|
Zfish   134 LYLFSSFTSELPWASCNNYWNTPSCM-----------------------EFSESNITEYSPNKTT 175

  Fly   225 DPVKEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLL 289
            .||.||||||.|.:|.|||:|||:||:||..|||.||:||||:|||||.|||||||||.|||::|
Zfish   176 SPVIEFWERRILGLSGGIEQIGNVRWDLALCLLLAWIICYFCVWKGVKSTGKVVYFTATFPYLML 240

  Fly   290 TILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNV 354
            .:|||||:|||||:.||.||:.|:.|:|.:.:||:||.:|||:|||:..|.|.|||||||:.||.
Zfish   241 IVLLVRGLTLPGAINGITFYLYPDPSRLKDPQVWMDAGSQIFYSYGVCTGVLTALGSYNKYDNNC 305

  Fly   355 YKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMW 419
            |:|.:.:|.:||.||..|||.||||:||||.||...::.||.|||||||:.||.||..:|...:|
Zfish   306 YRDCVYLCLLNSLTSFVAGFAIFSVLGFMADEQGVDISLVAESGPGLAFIAYPRAVALMPLPQLW 370

  Fly   420 SCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLR--KRKEIFIAIVCALSYLVGLTCITQGGM 482
            :..||.|::.:||||:|...|..:|:|.|.:|...:  .|::..:..:|:.|:.|||..:|:||:
Zfish   371 AIFFFIMIIFLGLDSEFVYQEALVTSISDMYPSFFQVGHRRKFLLLFICSASFFVGLLMVTEGGL 435

  Fly   483 YIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICL 547
            |:||:.|.||.||..||.....:.:.:.|.||.||.||.::|||||.|..:.|.||...|||||.
Zfish   436 YVFQLFDYYACSGMTLLTFAILQSICVGWVYGADRHYDCVEDMIGYRPWPFMKCCWKYLTPAICT 500

  Fly   548 GVFFFNIVQWTPVKY-LDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVRI 611
            |.|.|::||:||:|: .:|.||||.:|.|.|..|||.|.:||:|.:|...|||.:.:::|||...
Zfish   501 GTFIFSLVQYTPLKFNNEYEYPWWGYAIGGFFTLSSTLLVPLWMIYLVGTTPGSMRQRVRALCTP 565

  Fly   612 DEDV 615
            .||:
Zfish   566 AEDL 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	279/559 (50%)
slc6a22.2	XP_005166102.1	SLC6sbd-TauT-like	28..565	CDD:271387	279/559 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820