DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and slc6a11a

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001091857.1	Gene:	slc6a11a / 558960	ZFINID:	ZDB-GENE-030131-3729	Length:	590	Species:	Danio rerio

Alignment Length:	581	Identity:	274/581 - (47%)
Similarity:	390/581 - (67%)	Gaps:	25/581 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 TTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIIT 103
            :|..|.|:|..:..|   :||.|::|::|:|:|.|..|||||||||||||||||||||.:||::.
Zfish     5 STRRTGNQQADITPE---ERGQWANKIEFLLTVAGAIIGLGNVWRFPYLCYKNGGGAFFIPYVLY 66

  Fly   104 LFLAGIPMFFMELALGQMLTIGGLGVF-KIAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFM 167
            |...|||:|.:|.:|||..:.||:..: |:.|:|:|:|||:.::..:.::.||:|:|||..|.|.
Zfish    67 LVTCGIPLFVLETSLGQYTSQGGIMCWRKVCPLFEGMGYASQLIIVYGSITYIIIIAWAFLYLFS 131

  Fly   168 SMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNITSLELTDPVKEFWE 232
            |...::||.:|||.|||..|:             :::|........|.||.:|     .|.|||.
Zfish   132 SFNVELPWASCNNPWNTDTCI-------------VLSGRNSSSELASPLNSSS-----SVMEFWH 178

  Fly   233 RRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGI 297
            .|.|::|.|:|.:|.:||:||..|||||||.|||||||||.|||.|||||.||||:|.|||:||:
Zfish   179 HRVLRLSSGVEHLGTVRWDLALILLLVWILVYFCIWKGVKSTGKAVYFTATFPYVMLLILLLRGV 243

  Fly   298 TLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVC 362
            ||||||.||.:|:.|:.::|.:.:||:||.||||:||.:.||.|.:|||||::.||.|:|:..:|
Zfish   244 TLPGALNGIYYYMYPDLTRLADPQVWMDAGTQIFYSYAICLGYLSSLGSYNQYNNNCYRDSFYLC 308

  Fly   363 TVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFML 427
            .:||.||...||.||||:|.||.||...::.||.|||||.|:|||.||..||.|..|:..||.|:
Zfish   309 LLNSGTSFLGGFAIFSVLGHMAQEQGVDISLVAESGPGLVFIVYPQAVTMLPLSQFWAVCFFIMI 373

  Fly   428 LLIGLDSQFCTMEGFITAIIDEWPQLLRK--RKEIFIAIVCALSYLVGLTCITQGGMYIFQILDS 490
            :|:||||||..:|..:|::.|.:|.:||:  |:|:.:..:|.:.|.:||..||:||:||.|:.|.
Zfish   374 ILLGLDSQFVGLESIMTSVTDIFPTVLRRGFRREMLLLGICLVCYFMGLLMITEGGLYIIQLFDH 438

  Fly   491 YAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIV 555
            |..||..||:|...:.|:|.|.||.||||:.|:|||||.|....|:||...||::|:|.|.|::|
Zfish   439 YVCSGTTLLFLATCQSVAIGWVYGADRFYENIQDMIGYKPWPMVKYCWLYVTPSVCVGTFIFSLV 503

  Fly   556 QWTPVKYLD-YSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALVRIDEDV 615
            :::|:|:.: |.|||||:..|||.|:||:..||:.|.:...:..|...|:::......||:
Zfish   504 KYSPLKFNNKYMYPWWAYGIGWFLAVSSLSLIPINMIYKLHKGKGTFWERLQLACSPAEDL 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	267/556 (48%)
slc6a11a	NP_001091857.1	SLC6sbd-TauT-like	21..560	CDD:271387	267/556 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820