DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gat and slc6a6a

DIOPT Version :9

Sequence 1:	NP_651930.2	Gene:	Gat / 43805	FlyBaseID:	FBgn0039915	Length:	636	Species:	Drosophila melanogaster
Sequence 2:	NP_001119858.1	Gene:	slc6a6a / 556480	ZFINID:	ZDB-GENE-081104-1	Length:	625	Species:	Danio rerio

Alignment Length:	601	Identity:	310/601 - (51%)
Similarity:	417/601 - (69%)	Gaps:	29/601 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 VCKHESIEMSKELGHTTSLQSS---SPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAI 76
            :.:.|.::..|:. |..:|:.|   ||.|......:     .:.|.|..|:||:||:|||.|..:
Zfish     1 MAQKEKLQCLKDF-HKDTLKPSPGKSPGTRPEDEAE-----GKAPQREKWASKLDFVLSVAGGFV 59

  Fly    77 GLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVF-KIAPIFKGIG 140
            ||||||||||||||||||||::||.|.||..|:|:||:|:||||..:.||:..: |:.|||.|||
Zfish    60 GLGNVWRFPYLCYKNGGGAFLIPYFIFLFGGGLPVFFLEVALGQFTSEGGITCWGKLCPIFTGIG 124

  Fly   141 YAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIING 205
            ||:.::...:|:||||||||.::|.....:.::||..|.:.|||.|||....|||...|
Zfish   125 YASIIIVSLLNIYYIVILAWGLYYLLQCFQHELPWARCRHSWNTENCVEDTVRKNKTLW------ 183

  Fly   206 TTQKVCSVSALNITSLELTDPVKEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKG 270
                 .|.:|.|.||     ||.|||||..|.||.||:|:|.::||||..||.||::|:||||||
Zfish   184 -----LSANATNFTS-----PVTEFWERNVLSISSGIDEVGGLKWELALCLLAVWVICFFCIWKG 238

  Fly   271 VKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYG 335
            ||.|||||||||.||:::|.:||:||:|||||.||||||:.|:.|:|.:.||||||.|||||||.
Zfish   239 VKSTGKVVYFTATFPFLMLIVLLIRGVTLPGATEGIKFYLYPDLSRLKDPEVWIDAGTQIFFSYA 303

  Fly   336 LGLGTLVALGSYNKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPG 400
            :.||.:.:||||||:..|.|:|.:::..:||.||..:||.||||:||||.||...:||||.||||
Zfish   304 ICLGAMTSLGSYNKYKYNCYRDCMLLGCLNSGTSFVSGFAIFSVLGFMAQEQGIAIADVAESGPG 368

  Fly   401 LAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLRK--RKEIFIA 463
            |||:.||.||..:|...:|:.|||.||||:||||||..:||.||:::|.:|.||||  |:|||||
Zfish   369 LAFIAYPKAVTMMPLPTVWAILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSLLRKGYRREIFIA 433

  Fly   464 IVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGY 528
            ::|.:|||:|||.:|:||||:||:.|.||.||.||||:.|||||:::|.||.|.|||.|:|||||
Zfish   434 VICVISYLLGLTMVTKGGMYVFQLFDYYAASGVCLLWVAFFECVAVAWVYGADNFYDAIEDMIGY 498

  Fly   529 YPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLD-YSYPWWAHAFGWFTALSSMLYIPLYMFW 592
            .|..|.|:.|.:.||.:|:|.|.|::|::.|:.|.. |.||.|:...||..||:||:.||:.:..
Zfish   499 RPNSWMKWSWMLITPVLCVGCFVFSLVKYKPLTYNKLYKYPDWSIGLGWALALASMICIPMMVVI 563

  Fly   593 LWKRTPGELSEKIRAL 608
            ...::.|.|.|:|:|:
Zfish   564 KIIQSDGSLIERIKAV 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	301/555 (54%)
slc6a6a	NP_001119858.1	SLC6sbd_TauT	41..582	CDD:271398	301/555 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920