Protein Alignment Gat and SLC6A20

DIOPT Version :9

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001372612.1
• Gene: SLC6A20 / 54716
• HGNCID: 30927
• Length: 603
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 201/614 - (32%)
• Similarity: 297/614 - (48%)
• Gaps: 118/614 - (19%)

  Fly    58 RGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYKNGGGAFILPYIITLFLAGIPMFFMELALGQML 122
            |..|::.:.|:.:.:..|:||||||||||||...|||:|::||||.|.:.|:|:.::|||:||.:
Human     5 RPLWANSLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRM 69

  Fly   123 TIGGLGVFK-IAPIFKGIGYAAAVMSCWMNVYYIVILAWAVFYFFMSMRADVPWRTCNNWWNTVN 186
            ..|.:|.:: |:|...|:|.|:.|:|.::::||.||.|||.:|.|.|.:..:||..|.
Human    70 RQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWAFWYLFHSFQDPLPWSVCP------- 127

  Fly   187 CVSQYERKNLHCWDKIINGTTQKVCSVSALNIT----SLELTDPVKEFWERRALQISHGIEEIGN 247
                            :||           |.|    ..|.....:.||.|:.|.||..::|.|.
Human   128 ----------------LNG-----------NHTGYDEECEKASSTQYFWYRKTLNISPSLQENGG 165

  Fly   248 IRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALFPYVLLTILLVRGITLPGALEGIKFYIIP 312
            ::||.|..|||.|::.|.||.:|.:.|||||||||..||.:|.|.|:||:||.||..|:.:...|
Human   166 VQWEPALCLLLAWLVVYLCILRGTESTGKVVYFTASLPYCVLIIYLIRGLTLHGATNGLMYMFTP 230

  Fly   313 NFS-----------KLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNKFTNNVYKDALIVCTVNS 366
            ..|           :|.|.:.||:|.||||||.|||.|:|:|..|||:.:||..|.|:||..:||
Human   231 KGSSALSLLAFQIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSLINS 295

  Fly   367 STSMFAGFVIFSVIGFMA---------------------------------------------HE 386
            .||:||..|.||:.||.|                                             :.
Human   296 FTSIFASIVTFSIYGFKATFNYENCLKKVSLLLTNTFDLEDGFLTASNLEQVKGYLASAYPSKYS 360

  Fly   387 QQRP---------VADVAASGPGLAFLVYPSAVLQLPGSPMWSCLFFFMLLLIGLDSQFCTMEGF 442
            :..|         ..|.|..|.||||:||..|:..:..|.:||.|:|||||::|:.|........
Human   361 EMFPQIKNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTAAI 425

  Fly   443 ITAIIDEWPQLLRKRKEIFIAIVCALSYLVGLTCITQGGMYIFQILDSYAVSGFCLLWLIFFECV 507
            :|.:.|.........||....:||.::..:|:....:.|.|.|.|.:.||.: ..||.::..|.:
Human   426 LTPLTDSKIISSHLPKEAISGLVCLVNCAIGMVFTMEAGNYWFDIFNDYAAT-LSLLLIVLVETI 489

  Fly   508 SISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPAICLGVFFFNIVQWTPVKYLDY------- 565
            ::.:.||:.||...:|.|.|...:.:||..|...:|.:.:.:|.|.:..:.....|.|
Human   490 AVCYVYGLRRFESDLKAMTGRAVSWYWKVMWAGVSPLLIVSLFVFYLSDYILTGTLKYQAWDASQ 554

  Fly   566 ------SYPWWAHAFGWFTALSSMLYIPL 588
                  .||.:|.|.......||.:.|||
Human   555 GQLVTKDYPAYALAVIGLLVASSTMCIPL 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	201/614 (33%)
SLC6A20	NP_001372612.1	SLC6sbd_SIT1	2..588	CDD:271401	201/614 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810