Protein Alignment Gat and slc6a1b

DIOPT Version :9

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001007363.1
• Gene: slc6a1b / 492490
• ZFINID: ZDB-GENE-041114-57
• Length: 600
• Species: Danio rerio
• Alignment Length: 596
• Identity: 339/596 - (56%)
• Similarity: 436/596 - (73%)
• Gaps: 28/596 - (4%)

  Fly    28 GHTTSLQSSSPTTTDTSNKQQLVKIE---QLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCY 89
            ||..:..:.:||..| ..|..:||::   :||||.:|..|.||:||.||.||||||||||||||.
Zfish    11 GHVLTEVNEAPTAND-KPKTLVVKVQKKKELPDRETWQGKFDFLLSCVGYAIGLGNVWRFPYLCG 74

  Fly    90 KNGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFKIAPIFKGIGYAAAVMSCWMNVYY 154
            |||||||::||.:||..||:|:||:|.||||..:||||||:|:||:|||:|.||||:|.|:|:||
Zfish    75 KNGGGAFLIPYFLTLIFAGVPLFFLETALGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYY 139

  Fly   155 IVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNIT 219
            |||:|||::|.:.|...|:||::|:|.|||..|.|.|...|:.
Zfish   140 IVIIAWAIYYLYNSFTTDLPWKSCDNPWNTDKCFSNYSMANIG---------------------- 182

  Fly   220 SLELTDPVKEFWERRALQISHGIEEIGNIRWELAGTLLLVWILCYFCIWKGVKWTGKVVYFTALF 284
              .:|..|.|||||...|::.|:|:.|.||..||.||.:.|:|.||||||||.||||||||:|.:
Zfish   183 --NMTSAVVEFWERNMHQLTDGLEKPGEIRLPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATY 245

  Fly   285 PYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSYNK 349
            ||.:|.||.:||:|||||.|||.||:.|.||||..||||:||.||||||||||||:|:||||||.
Zfish   246 PYFMLFILFIRGVTLPGAKEGILFYVTPEFSKLKESEVWLDAATQIFFSYGLGLGSLIALGSYNP 310

  Fly   350 FTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMAHEQQRPVADVAASGPGLAFLVYPSAVLQLP 414
            |.||||||::|||.:||.|||||||||||::|||||..:||:|||||||||||||.||.||.|||
Zfish   311 FNNNVYKDSIIVCCINSFTSMFAGFVIFSIVGFMAHITKRPIADVAASGPGLAFLAYPEAVTQLP 375

  Fly   415 GSPMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLRKRKEIFIAIVCALSYLVGLTCITQ 479
            .||:|:.|||.|||::|:||||||:||||||::||:|:.||.|:|||||:||.:|||:||:.|||
Zfish   376 ISPLWAVLFFSMLLMLGIDSQFCTVEGFITALVDEFPRALRGRREIFIAVVCLVSYLIGLSNITQ 440

  Fly   480 GGMYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFCWCVTTPA 544
            ||:|:|::.|.|:.||.|||:|:|||||||||.|||::||..:::||||.|.:|||.||.|.||.
Zfish   441 GGLYVFKLFDYYSASGMCLLFLVFFECVSISWFYGVNKFYGNLEEMIGYKPCIWWKLCWVVFTPL 505

  Fly   545 ICLGVFFFNIVQWTPVKYLDYSYPWWAHAFGWFTALSSMLYIPLYMFWLWKRTPGELSEKIRALV 609
            |..|||.|:.||..|:...:|.:|.|....||..|||||:.||.||.:::....|...|::|.::
Zfish   506 IVAGVFLFSAVQMVPLTLNNYVFPKWGQGVGWCMALSSMVLIPGYMGYMFLTLKGSYKERLRIMI 570

  Fly   610 RIDEDVTRLRE 620
            :......|.:|
Zfish   571 QPTAAAVRTQE 581

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	326/552 (59%)
slc6a1b	NP_001007363.1	SLC5-6-like_sbd	2..600	CDD:294310	339/596 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	713	1.000	Domainoid score	I113
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2290
Inparanoid	1	1.050	730	1.000	Inparanoid score	I600
OMA	1	1.010	-	-		QHG49243
OrthoDB	1	1.010	-	-		D145627at33208
OrthoFinder	1	1.000	-	-		FOG0000575
OrthoInspector	1	1.000	-	-		otm25299
orthoMCL	1	0.900	-	-		OOG6_100347
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3258
SonicParanoid	1	1.000	-	-		X3352
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.870