Protein Alignment Gat and Slc6a16

DIOPT Version :10

• Sequence 1: NP_651930.2
• Gene: Gat / 43805
• FlyBaseID: FBgn0039915
• Length: 636
• Species: Drosophila melanogaster
• Sequence 2: NP_001311464.1
• Gene: Slc6a16 / 381884
• MGIID: 2685930
• Length: 742
• Species: Mus musculus
• Alignment Length: 654
• Identity: 160/654 - (24%)
• Similarity: 276/654 - (42%)
• Gaps: 123/654 - (18%)

  Fly    26 ELGHTTSLQSSSPTTTDTSNKQQLVKIEQLPDRGSWSSKMDFILSVVGLAIGLGNVWRFPYLCYK 90
            ||...|:|:..|   ::..|:......|..|.|..|:||::::|:::...:....|.||......
Mouse    96 ELATVTTLEQES---SELVNRMSRESSEGYPPRQLWASKVEYMLAIMSYLLMPSGVLRFASGWVH 157

  Fly    91 NGGGAFILPYIITLFLAGIPMFFMELALGQMLTIGGLGVFK-IAPIFKGIGYAAAVMSCWM-NVY 153
            .|..:|.:.||:.|...|||:.|:|:|:||........::| ::|.|.|:|| :.||.|:: |.|
Mouse   158 KGSCSFFIAYILMLLGIGIPLLFLEMAVGQRAQQSSADMWKNLSPWFGGVGY-SMVMVCFITNTY 221

  Fly   154 YIVILAWAVFYFFMSMRADVPWRTCNNWWNTVNCVSQYERKNLHCWDKIINGTTQKVCSVSALNI 218
            ..|..:|.:||........|||..|....|:.|...:.|:...:.:
Mouse   222 LNVFNSWILFYMSHIFYFVVPWDQCPLQRNSSNFDPECEQATSYTY------------------- 267

  Fly   219 TSLELTDPVKEFWERRALQISHGIEEIGNIRWELAGTLLLVW-ILCYFCIWKGVKWTGKVVYFTA 282
                       ||.|:.|:.|..||:.|...:.|..:|.|.: ::|.|.: .|:|..|||::...
Mouse   268 -----------FWYRKTLKASDRIEDGGQPSFSLGMSLFLSFCLICAFLV-NGIKSIGKVLFVLL 320

  Fly   283 LFPYVLLTILLVRGITLPGALEGIKFYIIPNFSKLTNSEVWIDAVTQIFFSYGLGLGTLVALGSY 347
            |.||.::...|:|.:::.||..|:|..:|...:.:::..:|..|..|:.|..|||.|.:|:|.|:
Mouse   321 LVPYSIIVCFLIRTLSMDGAEYGLKHLLILKVASISDLTIWCHAGIQVLFDIGLGFGPIVSLASH 385

  Fly   348 NKFTNNVYKDALIVCTVNSSTSMFAGFVIFSVIGFMA--------HEQQRPVADVAASG------ 398
            ....||...||.::......|.:.....:.|::||.|        .:.|..:..:.|.|
Mouse   386 VPDFNNCMADAFLMALFKIITLLMTTPFLLSILGFWATTTTHHCCKKNQETLLRLVAQGILPPDA 450

  Fly   399 -----------------------------------------------PGLAFLVYPSAVLQLPGS 416
                                                           |...||::...:..||||
Mouse   451 QPPDLSGNPTSNYNSWLSSLPPPLRSAVLSVVPECSVQKQFLKIKDNPRFLFLIFTEVISLLPGS 515

  Fly   417 PMWSCLFFFMLLLIGLDSQFCTMEGFITAIIDEWPQLLRKRKEIFIAIVCALSYLVGLTCITQGG 481
            ..|..|||.:||.:||.|....|.|.:..:.|.:| ..|::..:.|..|....:|.||..|...|
Mouse   516 GFWIVLFFLLLLTLGLCSNLMFMLGNVLTLQDTFP-FCRRQPRLLIVCVSMAMFLCGLIFIQPSG 579

  Fly   482 MYIFQILDSYAVSGFCLLWLIFFECVSISWCYGVDRFYDGIKDMIGYYPTVWWKFC---WCVTTP 543
            :|.|.:|....|: ..::.:|..|.::::|.||.|||   :.||:.......:..|   ||..:|
Mouse   580 IYYFSLLSECWVA-VPVIIIIICENLAVAWAYGADRF---LADMVALLGRPIFSGCGWLWCYISP 640

  Fly   544 AICLGVF---FFNIVQWTPVKYLDYS----------YPWWAHAFGWFTALSSMLYIPLYMFWLWK 595
            .:.||:.   |..:|: .|:.|..:.          :|.|:...  ...|:..:.:|:..::::.
Mouse   641 MVVLGLLTSVFVYLVK-GPLVYFAWDSSTSKEVVRVFPEWSKIL--IAGLTVFVLMPIPAYFVYC 702

  Fly   596 RTPG 599
            .|.|
Mouse   703 LTLG 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gat	NP_651930.2	SLC6sbd-TauT-like	58..611	CDD:271387	152/622 (24%)
Slc6a16	NP_001311464.1	SLC5-6-like_sbd	125..694	CDD:444915	149/608 (25%)